AIMC Topic: Biomarkers, Tumor
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Plasma and Urine Circulating Tumor DNA Methylation Profiles for Non-Invasive Pancreatic Ductal Adenocarcinoma Detection: Significant Findings in Plasma Only.
International journal of molecular sciences
May 22, 2025
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options, and early detection remains challenging due to the lack of reliable non-invasive biomarkers. This study investigated plasma and urine circulating tumor deo...
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.
Frontiers in immunology
May 22, 2025
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...
Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm.
Cancer biomarkers : section A of Disease markers
May 21, 2025
BackgroundNon-invasive methods with universal prognostic guidance for detecting breast cancer (BC) survival biomarkers need to be further explored.ObjectiveThis study aimed to investigate C-C motif chemokine receptor type 5 (CCR5) prognosis value in ...
Metabolic pathway alterations in cerebrospinal fluid as diagnostic biomarkers for primary central nervous system lymphoma.
Clinica chimica acta; international journal of clinical chemistry
May 19, 2025
Primary Central Nervous System Lymphoma (PCNSL) is a rare and aggressive type of hematological malignancy that can pose diagnostic challenges. Early detection is critical for effective treatment and better patient outcomes. The goal of this study was...
Integrative analysis of epigenetic and transcriptional interrelations identifies histotype-specific biomarkers in early-stage ovarian carcinoma.
Journal of ovarian research
May 19, 2025
BACKGROUND: Epithelial ovarian cancer (EOC) is a deadly and heterogenous disease comprising five major histotypes: clear cell carcinoma (CCC), endometrioid carcinoma (EC), low- and high-grade serous carcinoma (LGSC, HGSC), and mucinous carcinoma (MC)...
Identification of a panel of volatile organic compounds in urine for early detection of for bladder cancer.
Scientific reports
May 19, 2025
The absence of specific markers makes early detection of bladder cancer (BC) challenging. Recent studies have reported the reliable diagnostic significance of volatile organic compounds (VOCs) in several cancers. This study aimed to investigate wheth...
Exploring potential methylation markers for ovarian cancer from cervical scraping samples.
Human genomics
May 17, 2025
BACKGROUND: Ovarian cancer has the highest mortality rate among gynecological cancers, making early detection crucial, as the five-year survival rate drops from 92% with early-stage diagnosis compared to 31% with late-stage diagnosis. Current diagnos...
Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response.
Hereditas
May 16, 2025
BACKGROUND: Exosomes are extracellular vesicles that carry various biological substances and have potential as functional mediators in cancers. However, little is known about special molecules in colorectal cancer (CRC) exosomes and their immunologic...
Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis.
Scientific reports
May 15, 2025
Tumor budding (TB) and poorly differentiated clusters (PDCs) are features of infiltrative growth patterns and powerful independent prognostic factors in colorectal cancer (CRC), yet the underlying biological mechanisms behind their role in CRC invasi...
Development of a chitosanase 3-like protein 1 assay kit and study of its application in patients with hepatocellular carcinoma.
BMC biotechnology
May 12, 2025
OBJECTIVE: The detection kit for plasma Chitinase-3-like Protein 1 was developed using the magnetic bead chemiluminescence method, in order to investigate the diagnostic value of DD, FDP, CHI3L1, AFP-L3 and PIVKA-II in hepatocellular carcinoma.
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