AIMC Topic: Biomarkers
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IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid.
Frontiers in immunology
Dec 13, 2024
INTRODUCTION: Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients' quality of life. Despite the widespread attention these two diseases have garnered within the dermatological field, the...
A machine learning approach for identifying anatomical biomarkers of early mild cognitive impairment.
PeerJ
Dec 13, 2024
BACKGROUND: Alzheimer's Disease (AD) poses a major challenge as a neurodegenerative disorder, and early detection is critical for effective intervention. Magnetic resonance imaging (MRI) is a critical tool in AD research due to its availability and c...
Random survival forest model for early prediction of Alzheimer's disease conversion in early and late Mild cognitive impairment stages.
PloS one
Dec 13, 2024
With a clinical trial failure rate of 99.6% for Alzheimer's Disease (AD), early diagnosis is critical. Machine learning (ML) models have shown promising results in early AD prediction, with survival ML models outperforming typical classifiers by prov...
Blood Biomarker Signatures for Slow Gait Speed in Older Adults: An Explainable Machine Learning Approach.
Brain, behavior, and immunity
Dec 12, 2024
Maintaining physical function is crucial for independent living in older adults, with gait speed being a key predictor of health outcomes. Blood biomarkers may potentially monitor older adults' mobility, yet their association with slow gait speed sti...
The significance of long chain non-coding RNA signature genes in the diagnosis and management of sepsis patients, and the development of a prediction model.
Frontiers in immunology
Dec 12, 2024
BACKGROUND: Sepsis is a life-threatening organ dysfunction condition produced by dysregulation of the host response to infection. It is now characterized by a high clinical morbidity and mortality rate, endangering patients' lives and health. The pur...
Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.
Frontiers in immunology
Dec 11, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...
Subtyping strokes using blood-based protein biomarkers: A high-throughput proteomics and machine learning approach.
European journal of clinical investigation
Dec 10, 2024
BACKGROUND: Rapid diagnosis of stroke and its subtypes is critical in early stages. We aimed to discover and validate blood-based protein biomarkers to differentiate ischemic stroke (IS) from intracerebral haemorrhage (ICH) using high-throughput prot...
MRI classification of progressive supranuclear palsy, Parkinson disease and controls using deep learning and machine learning algorithms for the identification of regions and tracts of interest as potential biomarkers.
Computers in biology and medicine
Dec 10, 2024
BACKGROUND: Quantitative magnetic resonance imaging (MRI) analysis has shown promise in differentiating neurodegenerative Parkinsonian syndromes and has significantly advanced our understanding of diseases like progressive supranuclear palsy (PSP) in...
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning.
Biology direct
Dec 10, 2024
BACKGROUND: MicroRNAs (miRNAs) have shown potential as diagnostic biomarkers for myocardial infarction (MI) due to their early dysregulation and stability in circulation after MI. Moreover, they play a crucial role in regulating adaptive and maladapt...
Psoriatic arthritis in psoriasis: optimizing the current screening system for psoriatic arthritis based on serum data from U.S. and Chinese populations.
Frontiers in immunology
Dec 10, 2024
BACKGROUND: Psoriatic arthritis (PSA) is an inflammatory joint disease associated with psoriasis (PSO) that can be easily missed. Existing PSA screening tools ignore objective serologic indicators. The aim of this study was to develop a disease scree...
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