AIMC Topic: Cell Proliferation
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Optimization of biological activities of Agaricus species: an artificial intelligence-assisted approach.
Scientific reports
Jul 2, 2025
This study aims to determine the optimum extraction conditions that maximize the biological activities of Agaricus campestris and Agaricus bisporus species. In the study, a total of 64 extraction experiments were carried out at different temperatures...
Deep learning-driven drug response prediction and mechanistic insights in cancer genomics.
Scientific reports
Jul 1, 2025
In the field of cancer therapy, the diversity and heterogeneity of cancer genomes in clinical patients complicate and challenge the effective use of non-targeted drugs, as these drugs often fail to address specific genetic events. Recent advancements...
Machine learning developed LKB1-AMPK signaling related signature for prognosis and drug sensitivity in hepatocellular carcinoma.
Scientific reports
Jul 1, 2025
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, posing a significant threat to the life and health of people globally. LKB1-AMPK signaling pathway plays a significant role in the regulation of cellular metabolism, prolifera...
Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing.
Scientific reports
Jul 1, 2025
Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontology, pseudo-time, and cell communication analyses and explored their prognostic value in LUAD using a ...
Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.
ACS applied materials & interfaces
Jun 16, 2025
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...
Targeting INF2 with DiosMetin 7-O-β-D-Glucuronide: a new stratagem for colorectal cancer therapy.
BMC cancer
Jun 1, 2025
BACKGROUND AND PURPOSE: Colorectal cancer (CRC) is the third most prevalent malignancy in the gastrointestinal tract and the second leading cause of cancer-related deaths. Despite the identification of numerous biomarkers, their non-specific distribu...
Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.
International immunopharmacology
May 31, 2025
Endometrial adenocarcinoma carries a bleak prognosis, and the molecular markers that evaluate the progression of endometrial adenocarcinoma to advanced stages remain uncertain. Cell-cell communication plays a crucial role in the tumor microenvironmen...
Female
Tumor Microenvironment
Animals
Gene Expression Profiling
Mice
Multiomics
Gene Expression Regulation, Neoplastic
Transcriptome
Cell Line, Tumor
Humans
Ligands
Endometrial Neoplasms
Prognosis
Oncostatin M
Oncostatin M Receptor beta Subunit
Cell Proliferation
Signal Transduction
Adenocarcinoma
Mice, Nude
Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.
Experimental eye research
May 23, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
A potential new strategy for BC treatment: NPs containing solanine and evaluation of its anticancer and antimetastatic properties.
BMC cancer
May 12, 2025
Solanine has been shown to inhibit cancer by regulating the expression of apoptosis (Bax, Bcl-2) and metastasis (CDH-1, MMP2) genes in various cancer cell types. We synthesized optimized niosome NPs (NPs) with high solubility and capacity for solanin...
Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study.
BMC oral health
May 10, 2025
BACKGROUND: Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for de...
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