AIMC Topic: Clinical Trials as Topic

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Current status and limitations of artificial intelligence in colonoscopy.

United European gastroenterology journal Jun 7, 2021
BACKGROUND: Artificial intelligence (AI) using deep learning methods for polyp detection (CADe) and characterization (CADx) is on the verge of clinical application. CADe already implied its potential use in randomized controlled trials. Further effor...
Humans Artificial Intelligence Colonoscopy Colonic Neoplasms Quality Improvement Colonic Polyps Clinical Trials as Topic Precancerous Conditions Diagnosis, Computer-Assisted Deep Learning Adenoma Randomized Controlled Trials as Topic
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The case for AI-driven cancer clinical trials - The efficacy arm in silico.

Biochimica et biophysica acta. Reviews on cancer May 31, 2021
Pharmaceutical agents in oncology currently have high attrition rates from early to late phase clinical trials. Recent advances in computational methods, notably causal artificial intelligence, and availability of rich clinico-genomic databases have ...
Research Design Computer Simulation Precision Medicine Clinical Decision-Making Humans Artificial Intelligence Clinical Trials as Topic Molecular Targeted Therapy Biomarkers, Tumor Neoplasms Antineoplastic Agents Genomics
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Deep learning predicts cardiovascular disease risks from lung cancer screening low dose computed tomography.

Nature communications May 20, 2021
Cancer patients have a higher risk of cardiovascular disease (CVD) mortality than the general population. Low dose computed tomography (LDCT) for lung cancer screening offers an opportunity for simultaneous CVD risk estimation in at-risk patients. Ou...
Humans Retrospective Studies Clinical Trials as Topic Mass Screening Middle Aged Follow-Up Studies Risk Assessment Datasets as Topic Lung Coronary Vessels Deep Learning Aged, 80 and over ROC Curve Tomography, X-Ray Computed Adult Image Processing, Computer-Assisted Female Male Lung Neoplasms Risk Factors Cardiovascular Diseases Electrocardiography Aged
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Moving Forward in the Next Decade: Radiation Oncology Sciences for Patient-Centered Cancer Care.

JNCI cancer spectrum May 17, 2021
In a time of rapid advances in science and technology, the opportunities for radiation oncology are undergoing transformational change. The linkage between and understanding of the physical dose and induced biological perturbations are opening entire...
Neutron Capture Therapy Relative Biological Effectiveness Radiopharmaceuticals Photochemotherapy Clinical Trials as Topic Radiotherapy Hyperthermia, Induced Radiation Tolerance Radiobiology Research Support as Topic Neoplasms Big Data Radiation Oncology Patient-Centered Care Humans Artificial Intelligence Research
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Utilizing Artificial Intelligence to Manage COVID-19 Scientific Evidence Torrent with Risklick AI: A Critical Tool for Pharmacology and Therapy Development.

Pharmacology Apr 28, 2021
INTRODUCTION: The SARS-CoV-2 pandemic has led to one of the most critical and boundless waves of publications in the history of modern science. The necessity to find and pursue relevant information and quantify its quality is broadly acknowledged. Mo...
Registries Pharmacology Clinical Trials as Topic Evidence-Based Medicine Humans Artificial Intelligence COVID-19 Drug Development Data Interpretation, Statistical
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Evaluating eligibility criteria of oncology trials using real-world data and AI.

Nature Apr 7, 2021
There is a growing focus on making clinical trials more inclusive but the design of trial eligibility criteria remains challenging. Here we systematically evaluate the effect of different eligibility criteria on cancer trial populations and outcomes ...
Humans Artificial Intelligence Patient Safety Proportional Hazards Models Clinical Laboratory Techniques Electronic Health Records Patient Selection Reproducibility of Results Medical Oncology Lung Neoplasms Datasets as Topic Carcinoma, Non-Small-Cell Lung Clinical Trials as Topic
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A knowledge base of clinical trial eligibility criteria.

Journal of biomedical informatics Apr 1, 2021
OBJECTIVE: We present the Clinical Trial Knowledge Base, a regularly updated knowledge base of discrete clinical trial eligibility criteria equipped with a web-based user interface for querying and aggregate analysis of common eligibility criteria.
Clinical Trials as Topic Humans Algorithms Databases, Factual Electronic Health Records Natural Language Processing Knowledge Bases
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Nonparametric machine learning for precision medicine with longitudinal clinical trials and Bayesian additive regression trees with mixed models.

Statistics in medicine Mar 9, 2021
Precision medicine is an active area of research that could offer an analytic paradigm shift for clinical trials and the subsequent treatment decisions based on them. Clinical trials are typically analyzed with the intent of discovering beneficial tr...
Computer Simulation Precision Medicine Cluster Analysis Bayes Theorem Clinical Trials as Topic Humans Machine Learning
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Deep Learning Approach to Parse Eligibility Criteria in Dietary Supplements Clinical Trials Following OMOP Common Data Model.

AMIA ... Annual Symposium proceedings. AMIA Symposium Jan 25, 2021
Dietary supplements (DSs) have been widely used in the U.S. and evaluated in clinical trials as potential interventions for various diseases. However, many clinical trials face challenges in recruiting enough eligible patients in a timely fashion, ca...
Patient Selection Models, Theoretical Clinical Trials as Topic Dietary Supplements Partnership Practice Natural Language Processing Humans Feasibility Studies Databases, Factual Electronic Health Records Deep Learning
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Early response to SPN-812 (viloxazine extended-release) can predict efficacy outcome in pediatric subjects with ADHD: a machine learning post-hoc analysis of four randomized clinical trials.

Psychiatry research Jan 5, 2021
Machine learning (ML) was used to determine whether early response can predict efficacy outcome in pediatric subjects with ADHD treated with SPN-812. We used data from four Phase 3 placebo-controlled trials of 100- to 600-mg/day SPN-812 (N=1397; 6-17...
Humans Attention Deficit Disorder with Hyperactivity Machine Learning Viloxazine Female Male Clinical Trials as Topic Drug Administration Schedule Central Nervous System Stimulants Delayed-Action Preparations Adolescent Dose-Response Relationship, Drug Child Randomized Controlled Trials as Topic Treatment Outcome Double-Blind Method Body Mass Index Body Weight
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