AIMC Topic: Disease Models, Animal
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Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-B/p65 Signaling in Chronic Radiculitis Rats.
Pain research & management
Dec 13, 2018
BACKGROUND: Oxygen/ozone therapy is a minimally invasive technique for the treatment of radiculitis from lumbar disc herniation. This study aimed at investigating whether intrathecal administration of low-concentration oxygen/ozone could attenuate ch...
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.
Nature communications
Dec 3, 2018
Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherap...
A neural network approach to analyze cross-sections of muscle fibers in pathological images.
Computers in biology and medicine
Nov 12, 2018
Morphological characteristics of muscle fibers, such as their cross-sections, are important indicators of the health and function of the musculoskeletal system. However, manual analysis of muscle fiber morphology is a labor-intensive and time-consumi...
Placental CD4 T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats.
Pregnancy hypertension
Nov 2, 2018
Preeclampsia (PE), new onset hypertension during pregnancy, is associated with a proinflammatory profile compared to normal pregnancy (NP). We hypothesize that CD4 T cells from PE patient placentas cause PE symptoms during pregnancy compared to those...
Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Arterial Pressure
Placentation
Rats, Nude
Tumor Necrosis Factor-alpha
Pregnancy
Female
Young Adult
Humans
Rats
Enzyme-Linked Immunosorbent Assay
Disease Models, Animal
Placenta
CD4-Positive T-Lymphocytes
Adult
Animals
Real-Time Polymerase Chain Reaction
Interleukin-17
Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro.
Neurological research
Oct 17, 2018
Epilepsy is a neurological disorder affecting 50 million individuals globally. Modern research has inspected the likelihood of forecasting epileptic seizures. Algorithmic investigations are giving promising results for seizure prediction. Though most...
Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.
American journal of physiology. Renal physiology
Sep 26, 2018
Current methods of scoring histological kidney samples, specifically glomeruli, do not allow for collection of quantitative data in a high-throughput and consistent manner. Neither untrained individuals nor computers are presently capable of identify...
Disease Models, Animal
Mice, Inbred C57BL
Kidney Diseases
Predictive Value of Tests
Animals
Male
Diagnosis, Computer-Assisted
Rats
Image Interpretation, Computer-Assisted
Pattern Recognition, Automated
Species Specificity
Mice, Transgenic
Biopsy
Workflow
Kidney Glomerulus
Microscopy
Humans
Machine Learning
Software
Automation, Laboratory
Phenotype
Female
Reproducibility of Results
Determining optimal ultrasound percent on time with long-pulse torsional phacoemulsification.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
Sep 11, 2018
OBJECTIVE: To evaluate the optimum percent on time for the most efficient lens fragment removal using long-pulse torsional ultrasound (US).
Temporal Performance of Laplacian Eigenmaps and 3D Conduction Velocity in Detecting Ischemic Stress.
Journal of electrocardiology
Aug 13, 2018
BACKGROUND: Myocardial ischemia has a complex and time-varying electrocardiographic signature that is used to diagnose and stratify severity. Despite the ubiquitous clinical use of the ECG to detect ischemia, the sensitivity and specificity of ECG ba...
GOATOOLS: A Python library for Gene Ontology analyses.
Scientific reports
Jul 18, 2018
The biological interpretation of gene lists with interesting shared properties, such as up- or down-regulation in a particular experiment, is typically accomplished using gene ontology enrichment analysis tools. Given a list of genes, a gene ontology...
High vacuum and aspiration on phacoemulsification efficiency and chatter for Centurion.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
May 18, 2018
OBJECTIVE: To compare relative efficiency and chatter of high aspiration and vacuum settings.
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