AIMC Topic: Gene Regulatory Networks

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Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to fatty acid metabolism-associated genes.

Scientific reports Nov 22, 2024
Sepsis, characterized as a systemic inflammatory response triggered by the invasion of pathogens, represents a continuum that may escalate from mild systemic infection to severe sepsis, potentially resulting in septic shock and multiple organ dysfunc...
Computational Biology Biomarkers Lipid Metabolism Gene Expression Profiling Fatty Acids Sepsis Gene Regulatory Networks Humans Machine Learning
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The diagnostic value investigation of programmed cell death genes in heart failure.

BMC cardiovascular disorders Nov 22, 2024
BACKGROUND: We aimed to identify the potential diagnostic markers and associated molecular mechanisms based on programmed cell death (PCD)-related genes in patients with heart failure (HF).
Case-Control Studies Protein Interaction Maps Gene Regulatory Networks Nomograms Databases, Genetic Apoptosis Predictive Value of Tests Genetic Markers Humans Machine Learning Heart Failure Reproducibility of Results Plasminogen Activator Inhibitor 1 Gene Expression Profiling Gene Expression Regulation Transcriptome Apoptosis Regulatory Proteins
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Identification of diagnostic genes and the miRNA‒mRNA‒TF regulatory network in human oocyte aging via machine learning methods.

Journal of assisted reproduction and genetics Nov 14, 2024
PURPOSE: Oocyte aging is a significant factor in the negative reproductive outcomes of older women. However, the pathogenesis of oocyte aging remains unclear. This study aimed to identify the hub genes involved in oocyte aging via bioinformatics meth...
Gene Regulatory Networks Computational Biology RNA, Messenger Transcription Factors Oocytes MicroRNAs Cellular Senescence Humans Machine Learning Female Gene Expression Profiling
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Discovery of key molecular signatures for diagnosis and therapies of glioblastoma by combining supervised and unsupervised learning approaches.

Scientific reports Nov 11, 2024
Glioblastoma (GBM) is the most malignant brain cancer and one of the leading causes of cancer-related death globally. So, identifying potential molecular signatures and associated drug molecules are crucial for diagnosis and therapies of GBM. This st...
Glioblastoma Supervised Machine Learning Gene Regulatory Networks Humans Gene Expression Regulation, Neoplastic Biomarkers, Tumor DNA Methylation Brain Neoplasms Unsupervised Machine Learning Molecular Docking Simulation Gene Expression Profiling Transcriptome
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Interpretable machine learning uncovers epithelial transcriptional rewiring and a role for Gelsolin in COPD.

JCI insight Nov 8, 2024
Transcriptomic analyses have advanced the understanding of complex disease pathophysiology including chronic obstructive pulmonary disease (COPD). However, identifying relevant biologic causative factors has been limited by the integration of high di...
Machine Learning Female Gene Regulatory Networks Pulmonary Disease, Chronic Obstructive Mice Male Animals Disease Models, Animal Humans Lung Epithelial Cells Gene Expression Profiling Gelsolin Transcriptome
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The shared biomarkers and immune landscape in psoriatic arthritis and rheumatoid arthritis: Findings based on bioinformatics, machine learning and single-cell analysis.

PloS one Nov 7, 2024
OBJECTIVE: Psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are the most common types of inflammatory musculoskeletal disorders that share overlapping clinical features and complications. The aim of this study was to identify shared marker gen...
Single-Cell Analysis Transcription Factors Gene Regulatory Networks Humans Arthritis, Rheumatoid Arthritis, Psoriatic Machine Learning Computational Biology Biomarkers Gene Expression Profiling
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Comprehensive Analysis of Immune Infiltration and Key Genes in Peri-Implantitis Using Bioinformatics and Molecular Biology Approaches.

Medical science monitor : international medical journal of experimental and clinical research Nov 6, 2024
BACKGROUND Peri-implantitis is the main cause of failure of implant treatment, and there is little research on its molecular mechanism. This study aimed to identify key biomarkers and immune infiltration of peri-implantitis using a bioinformatics met...
Molecular Biology Peri-Implantitis Computational Biology Support Vector Machine Databases, Genetic Gene Ontology Biomarkers Gene Expression Profiling Humans Transcriptome Gene Regulatory Networks Algorithms
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Screening of CAD-related secretory genes associated with type II diabetes based on comprehensive bioinformatics analysis and machine learning.

BMC cardiovascular disorders Nov 5, 2024
BACKGROUND: Type II diabetes mellitus (T2DM) is strongly linked with a heightened risk of coronary artery disease (CAD). Exploring biological targets common to T2DM and CAD is essential for CAD intervention strategies.
Humans Machine Learning Gene Expression Profiling Transcriptome Diabetes Mellitus, Type 2 Single-Cell Analysis Gene Regulatory Networks Female Aged Male Middle Aged Myocytes, Cardiac Genetic Predisposition to Disease Myocytes, Smooth Muscle Computational Biology Fibroblast Growth Factor 7 Databases, Genetic Coronary Artery Disease
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Exploration of common pathogenesis and candidate hub genes between HIV and monkeypox co-infection using bioinformatics and machine learning.

Scientific reports Nov 4, 2024
This study explored the pathogenesis of human immunodeficiency virus (HIV) and monkeypox co-infection, identifying candidate hub genes and potential drugs using bioinformatics and machine learning. Datasets for HIV (GSE 37250) and monkeypox (GSE 2412...
Coinfection Mpox, Monkeypox Gene Ontology Machine Learning Gene Expression Profiling HIV Infections Protein Interaction Maps Gene Regulatory Networks Humans Computational Biology Transcription Factors MicroRNAs
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Identification and validation of interferon-stimulated gene 15 as a biomarker for dermatomyositis by integrated bioinformatics analysis and machine learning.

Frontiers in immunology Nov 4, 2024
BACKGROUND: Dermatomyositis (DM) is an autoimmune disease that primarily affects the skin and muscles. It can lead to increased mortality, particularly when patients develop associated malignancies or experience fatal complications such as pulmonary ...
Gene Regulatory Networks Molecular Docking Simulation Humans Dermatomyositis Computational Biology Gene Expression Profiling Machine Learning Biopsy Gene Expression Regulation Case-Control Studies Cytokines Skin Molecular Targeted Therapy ROC Curve Biomarkers Ubiquitins
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