AIMC Topic: Half-Life

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The effects of environmental and compositional manipulations on the longevity of Tessari-made foam for sclerotherapy.

Journal of vascular surgery. Venous and lymphatic disorders Sep 4, 2014
BACKGROUND: Tessari-made foam sclerotherapy is performed around the world in a variety of clinics differing in methods, equipment, temperatures, and altitudes. We investigated how the following factors affected the foam's longevity: silicone vs nonsi...
Syringes Silicones Sclerosing Solutions Polyethylene Glycols Carbon Dioxide Half-Life Drug Stability Temperature Time Factors Sclerotherapy
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A comparison of machine learning methods for classification using simulation with multiple real data examples from mental health studies.

Statistical methods in medical research Sep 18, 2013
BACKGROUND: Recent literature on the comparison of machine learning methods has raised questions about the neutrality, unbiasedness and utility of many comparative studies. Reporting of results on favourable datasets and sampling error in the estimat...
Machine Learning Colorectal Neoplasms Mental Health Support Vector Machine Humans Sample Size Discriminant Analysis Half-Life Behavioral Research
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Development of machine learning-based quantitative structure-activity relationship models for predicting plasma half-lives of drugs in six common food animal species.

Toxicological sciences : an official journal of the Society of Toxicology Jan 1, 2025
Plasma half-life is a crucial pharmacokinetic parameter for estimating extralabel withdrawal intervals of drugs to ensure the safety of food products derived from animals. This study focuses on developing a quantitative structure-activity relationshi...
Machine Learning Algorithms Animals Swine Neural Networks, Computer Sheep Quantitative Structure-Activity Relationship Veterinary Drugs Cattle Turkeys Chickens Goats Half-Life
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Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

European journal of drug metabolism and pharmacokinetics Dec 1, 2020
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorph...
Humans Neural Networks, Computer Female Young Adult Cross-Over Studies Polymorphism, Single Nucleotide Multidrug Resistance-Associated Proteins Predictive Value of Tests Healthy Volunteers Multidrug Resistance-Associated Protein 2 Area Under Curve Half-Life Cytochrome P-450 CYP1A1 Asian People Drug Compounding Adult Polymorphism, Genetic Male Deferasirox Middle Aged Iron Chelating Agents Adolescent Glucuronosyltransferase
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Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria Jan 1, 2019
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} รจ un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Drug Substitution Antipsychotic Agents Humans Drug Interactions Ketoconazole Time Factors Cognition Disorders Receptor, Serotonin, 5-HT2A Schizophrenia Cytochrome P-450 CYP2D6 Inducers Piperazines Receptor, Serotonin, 5-HT2C Half-Life Cytochrome P-450 CYP3A Inducers Anhedonia
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Pharmacokinetics of a Single Intramuscular Injection of Long-Acting Ceftiofur Crystalline-Free Acid in Cattle Egrets ( Bubulcus ibis).

Journal of avian medicine and surgery Dec 1, 2017
We determined the pharmacokinetic properties of ceftiofur crystalline-free acid (CCFA), a long-acting antibiotic, after a single intramuscular injection in cattle egrets ( Bubulcus ibis). A dose of 20 mg/kg was administered intramuscularly to 18 bird...
Female Injections, Intramuscular Animals Male Birds Pilot Projects Area Under Curve Half-Life Cephalosporins Anti-Bacterial Agents
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THE EFFECT OF TOTAL AND PARTIAL NEPHRECTOMY ON THE PHARMACOKINETICS OF INTRAVENOUS PARACETAMOL IN HUMANS.

Acta poloniae pharmaceutica May 1, 2017
Paracetamol is one of the most common analgesic and antipyretic drugs. Recently intravenous paracetamol has been widely used to treat moderate postoperative pain. Surgery is the main method of treatment of renal cancer. Total or partial nephrectomy c...
Infusions, Intravenous Area Under Curve Drug Monitoring Models, Biological Antipyretics Chromatography, High Pressure Liquid Biological Availability Half-Life Adult Male Middle Aged Analgesics, Non-Narcotic Kidney Humans Kidney Neoplasms Nephrectomy Female Metabolic Clearance Rate Renal Elimination Aged Spectrophotometry, Ultraviolet Aged, 80 and over Acetaminophen
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica Mar 1, 2017
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Area Under Curve Models, Biological Sulfonamides Tablets Humans Healthy Volunteers Young Adult Half-Life Chromatography, High Pressure Liquid Male Metabolic Clearance Rate Pakistan Anti-Inflammatory Agents, Non-Steroidal Therapeutic Equivalency Administration, Oral Cross-Over Studies
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Pharmacokinetics of Amitriptyline HCl and Its Metabolites in Healthy African Grey Parrots ( Psittacus erithacus ) and Cockatoos (Cacatua Species).

Journal of avian medicine and surgery Dec 1, 2015
Amitriptyline, a tricyclic antidepressant, is used clinically to treat feather-destructive behavior in psittacine birds at a recommended dosage of 1-5 mg/kg PO q12-24h, which has been extrapolated from human medicine and based on anecdotal reports. T...
Adrenergic Uptake Inhibitors Amitriptyline Parrots Animals Dose-Response Relationship, Drug Half-Life Cockatoos Species Specificity
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