AIMC Topic: Humans

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Uncovering key biomarkers, potential therapeutic targets and development of deep learning model in heart failure.

PloS one
Heart failure (HF) represents a significant public health concern, characterized by elevated rates of mortality and morbidity. Recent advancements in gene sequencing technologies have led to the identification of numerous genes associated with heart ...

Lung and abdominal ultrasound accuracy for tuberculosis: An Indian prospective cohort study.

PloS one
BACKGROUND: Tuberculosis (TB) diagnosis remains a challenge, particularly in low-resource settings. Point-of-care ultrasound (POCUS) has shown promise, but most studies focus on HIV-infected populations. In the case of TB, data on lung ultrasound (LU...

Development, optimization, and preliminary evaluation of a novel artificial intelligence tool to promote patient health literacy in radiology reports: The Rads-Lit tool.

PloS one
Radiology reports are an integral part of patient medical records; however, these reports often contain complex medical terminology that are difficult for patients to comprehend, potentially leading to anxiety, misunderstanding, and misinterpretation...

AI-driven analysis of diabetes risk determinants in U.S. adults: Exploring disease prevalence and health factors.

PloS one
BACKGROUND: Diabetes remains a major public health concern in the United States, with a complex interplay of behavioral, demographic, and clinical risk factors. This study aims to identify the three best-performing machine learning models for diabete...

Synthetic biology meets diagnostics: Engineering biosensing platforms for rapid and accurate pathogen and viral detection.

Biosensors & bioelectronics
The integration of synthetic biology with biosensor technologies has catalyzed a paradigm shift in the development of programmable, field-deployable diagnostic systems for precision detection of pathogens and viral threats. This review provides a com...

Diagnostic PANoptosis-related genes in acute kidney injury: bioinformatics, machine learning, and validation.

Annals of medicine
BACKGROUND: Acute kidney injury (AKI) is a prevalent and life-threatening condition characterized by abrupt renal function decline and subsequent inflammatory cascades. PANoptosis has emerged as a significant contributor to the pathophysiology of AKI...

Multi-level validation of high expression of PLAUR, FOSL2, and SLC11A1 in aortic dissection and their clinical implications.

International immunopharmacology
Macrophages, pivotal orchestrators of the immune system, are integral to the initiation of specific immune responses and exert profound influence on the pathogenesis, progression, and therapeutic landscape of aortic dissection (AD). Leveraging the pr...

Deep learning-driven proteomics analysis for gene annotation in the renin-angiotensin system.

European journal of pharmacology
The renin-angiotensin system (RAS) is central to cardiovascular diseases such as hypertension and cardiomyopathy, yet the functions of many RAS genes remain unclear. This study developed a multi-label deep learning model to systematically annotate RA...

Explainable Deep Learning Framework for SERS Bioquantification.

ACS sensors
Surface-enhanced Raman spectroscopy (SERS) is rapidly gaining attention as a fast and inexpensive method of biomarker quantification, which can be combined with deep learning to elucidate complex biomarker-disease relationships. Current standard prac...

A 3D Nanofiltration Array for Direct Plasma EV Purification with Label-Free SERS Detection toward Accurate Clinical Breast Cancer Staging.

ACS sensors
Extracellular vesicles (EVs) have emerged as promising biomarkers in cancer diagnostics. However, rapid and nondestructive isolation of EVs from plasma remains challenging due to the presence of abundant interferents with smaller sizes (e.g., protein...