AIMC Topic: Lactic Acid
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Development and experimental verification of a prognosis model for hypoxia- and lactate metabolism-associated genes in HNSCC.
Medicine
Jun 13, 2025
Hypoxia and lactate metabolism are both distinctive characteristics of cancerous cells. Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent forms of cancer. The objective of this study was to construct a prognostic model of gen...
Artificial Intelligence-Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma.
Journal of cellular and molecular medicine
Jan 1, 2025
Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer-related mortality globally. Recent data point to a significant role for metab...
Unravelling the metabolic landscape of cutaneous melanoma: Insights from single-cell sequencing analysis and machine learning for prognostic assessment of lactate metabolism.
Experimental dermatology
Jun 1, 2024
This manuscript presents a comprehensive investigation into the role of lactate metabolism-related genes as potential prognostic markers in skin cutaneous melanoma (SKCM). Bulk-transcriptome data from The Cancer Genome Atlas (TCGA) and GSE19234, GSE2...
Four Biomarkers-Based Artificial Neural Network Model for Accurate Early Prediction of Bacteremia with Low-level Procalcitonin.
Annals of clinical and laboratory science
May 1, 2021
OBJECTIVE: Procalcitonin levels above 2.0 ng/mL are associated with a higher risk of severe sepsis. Bacteremia with procalcitonin levels lower than 2.0 ng/mL has not received much attention, and relevant prediction models are lacking. Herein, a panel...
The efficacy of support vector machines in modelling deviations from the Beer-Lambert law for optical measurement of lactate.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2020
Lactate is an important biomarker with a significant diagnostic and prognostic ability in relation to life-threatening conditions and diseases such as sepsis, diabetes, cancer, pulmonary and kidney diseases, to name a few. The gold standard method fo...
Blood Lactate Concentration Prediction in Critical Care.
Studies in health technology and informatics
Jun 16, 2020
Blood lactate concentration is a reliable risk indicator of deterioration in critical care requiring frequent blood sampling. However, lactate measurement is an invasive procedure that can increase risk of infections. Yet there is no clinical consens...
Human endurance and AI: Audentes Fortna Iuvat - fortune favours the bold.
Perfusion
Nov 1, 2019
Lactate levels and risk of lactic acidosis with metformin in diabetic kidney disease patients.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Jan 1, 2017
Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid ...
Bicarbonates
Acidosis, Lactic
Male
Treatment Outcome
Diabetes Mellitus, Type 2
Humans
Middle Aged
Hydrogen-Ion Concentration
Diabetic Nephropathies
Biomarkers
Risk Assessment
Administration, Oral
Hypoglycemic Agents
Female
Case-Control Studies
Metformin
Risk Factors
Renal Insufficiency, Chronic
Lactic Acid
Cell Free DNA and Procalcitonin as Early Markers of Complications in ICU Patients with Multiple Trauma and Major Surgery.
Clinical laboratory
Dec 1, 2016
BACKGROUND: Cell free DNA (cfDNA) was recently suggested as a new marker of sepsis and poor outcome in ICU patients. Procalcitonin has also been the focus of attention as an early marker for systemic inflammation and sepsis.
Injury Severity Score
Prognosis
Organ Dysfunction Scores
Intensive Care Units
Calcitonin
Female
Reproducibility of Results
Risk Factors
Area Under Curve
Humans
DNA
Biomarkers
Early Diagnosis
Cell-Free Nucleic Acids
Surgical Procedures, Operative
Length of Stay
Multiple Trauma
Lactic Acid
Adult
Sepsis
Predictive Value of Tests
Male
Time Factors
C-Reactive Protein
Middle Aged
Hospital Mortality
Postoperative Complications
ROC Curve
[Improvement effect of early goal-directed therapy on the prognosis in patients with septic shock].
Zhonghua wei zhong bing ji jiu yi xue
Nov 1, 2015
OBJECTIVE: To evaluate the effect of the early goal-directed therapy (EGDT) on mortality in patients with septic shock, and to analyze the risk factors of mortality.
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