AIMC Topic: Lipopolysaccharides

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Development of a hybrid model for a partially known intracellular signaling pathway through correction term estimation and neural network modeling.

PLoS computational biology Dec 14, 2020
Developing an accurate first-principle model is an important step in employing systems biology approaches to analyze an intracellular signaling pathway. However, an accurate first-principle model is difficult to be developed since it requires in-dept...
Signal Transduction Apoptosis Lipopolysaccharides Least-Squares Analysis NF-kappa B Neural Networks, Computer Algorithms
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Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways.

Journal of dietary supplements Oct 14, 2020
Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblas...
Cholinergic Agents Coconut Oil Animals Neuroprotection Oxidative Stress Rats, Wistar Lipopolysaccharides Rats Anti-Inflammatory Agents Acetylcholinesterase
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Automatization and improvement of μCT analysis for murine lung disease models using a deep learning approach.

Respiratory research May 24, 2020
BACKGROUND: One of the main diagnostic tools for lung diseases in humans is computed tomography (CT). A miniaturized version, micro-CT (μCT) is utilized to examine small rodents including mice. However, fully automated threshold-based segmentation an...
Mice Lipopolysaccharides Mice, Inbred C57BL Lung Diseases Pattern Recognition, Automated Female Animals Male Deep Learning Absorptiometry, Photon X-Ray Microtomography
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Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.

Drug design, development and therapy Feb 20, 2020
BACKGROUND: Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and fu...
Medicine, Chinese Traditional Lipopolysaccharides Neural Networks, Computer Anti-Inflammatory Agents Cell Survival Cells, Cultured Drugs, Chinese Herbal Cytokines Capsules Animals RAW 264.7 Cells Mice Databases, Pharmaceutical Nitric Oxide Adenomyosis
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Noninvasive detection of macrophage activation with single-cell resolution through machine learning.

Proceedings of the National Academy of Sciences of the United States of America Mar 6, 2018
We present a method enabling the noninvasive study of minute cellular changes in response to stimuli, based on the acquisition of multiple parameters through label-free microscopy. The retrieved parameters are related to different attributes of the c...
Machine Learning Progesterone Spectrum Analysis, Raman Lipopolysaccharides Dose-Response Relationship, Drug Microscopy, Fluorescence Animals Single-Cell Analysis Image Processing, Computer-Assisted Mice Models, Biological RAW 264.7 Cells Macrophage Activation
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Simvastatin and nanofibrous poly(l-lactic acid) scaffolds to promote the odontogenic potential of dental pulp cells in an inflammatory environment.

Acta biomaterialia Dec 30, 2017
UNLABELLED: In this study, we investigated the anti-inflammatory, odontogenic and pro-angiogenic effects of integrating simvastatin and nanofibrous poly(l-lactic acid) (NF-PLLA) scaffolds on dental pulp cells (DPCs). Highly porous NF-PLLA scaffolds t...
Mesenchymal Stem Cells Neovascularization, Physiologic Humans Polyesters Biomarkers Simvastatin Dental Pulp Gene Expression Regulation Cytoprotection Young Adult Tissue Scaffolds Cell Differentiation Nanofibers RNA, Messenger Human Umbilical Vein Endothelial Cells Odontogenesis Inflammation Alkaline Phosphatase Signal Transduction Lipopolysaccharides
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Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.

PloS one Dec 27, 2017
The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD...
Cyclooxygenase 2 Humans NF-kappa B Transcription, Genetic Tumor Necrosis Factor-alpha Lymphocyte Antigen 96 HEK293 Cells Glycosylation Lipopolysaccharide Receptors Candida albicans Toll-Like Receptor 4 Lipopolysaccharides Membrane Glycoproteins Interleukin-8
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Gas chromatography-mass spectrometry metabolomic study of lipopolysaccharides toxicity on rat basophilic leukemia cells.

Chemico-biological interactions Dec 22, 2017
Lipopolysaccharide (LPS) can lead to uncontrollable cytokine production, fatal sepsis syndrome and depression/multiple organ failure, as pathophysiologic demonstration. Various toxic effects of LPS have been extensively reported, mainly on the toxici...
Discriminant Analysis Amino Acids Gas Chromatography-Mass Spectrometry Down-Regulation Leukemia, Basophilic, Acute Metabolomics Mast Cells Principal Component Analysis Animals Metabolic Networks and Pathways Cell Line, Tumor Rats Apoptosis Lipopolysaccharides
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Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Humans Cytokines Reproducibility of Results Enzyme-Linked Immunosorbent Assay Apoptosis Lipopolysaccharides Cell Line Reactive Oxygen Species Epithelial Cells Ginsenosides Nephritis Phosphatidylinositol 3-Kinases Cell Survival Proto-Oncogene Proteins c-akt Protective Agents Analysis of Variance Blotting, Western Kidney Tubules Anti-Inflammatory Agents Cell Migration Assays
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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
Alkaloids HT29 Cells Tumor Cells, Cultured Murraya Drug Screening Assays, Antitumor Structure-Activity Relationship Anti-Inflammatory Agents, Non-Steroidal Zebrafish Animals Mice Nitric Oxide Cell Proliferation Apoptosis Lipopolysaccharides Dose-Response Relationship, Drug Cell Survival Antineoplastic Agents, Phytogenic Humans Cytokines
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