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Integrated multi-omics analysis and machine learning refine molecular subtypes and clinical outcome for hepatocellular carcinoma.

Hereditas
The high morbidity and mortality of hepatocellular carcinoma (HCC) impose a substantial economic burden on patients' families and society, and the majority of HCC patients are detected at advanced stages and experience poor therapeutic outcomes, wher...

Deep learning-based identification of patients at increased risk of cancer using routine laboratory markers.

Scientific reports
Early screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to determine the...

Estimating gait parameters from sEMG signals using machine learning techniques under different power capacity of muscle.

Scientific reports
The gait analysis has been applied in many fields, such as the assessment of falling, force evaluation in sports, and gait disorder detection for neuromuscular diseases. Its main recording techniques include video cameras and wearable sensors. Howeve...

Machine learning-based differentiation of schizophrenia and bipolar disorder using multiscale fuzzy entropy and relative power from resting-state EEG.

Translational psychiatry
Schizophrenia (SZ) and bipolar disorder (BD) pose diagnostic challenges due to overlapping clinical symptoms and genetic factors, often resulting in misdiagnosis and suboptimal treatment outcomes. This study aimed to identify EEG-based biomarkers tha...

Remdesivir associated with reduced mortality in hospitalized COVID-19 patients: treatment effectiveness using real-world data and natural language processing.

BMC infectious diseases
BACKGROUND: Remdesivir (RDV) was the first antiviral approved for mild-to-moderate COVID-19 and for those patients at risk for progression to severe disease after clinical trials supported its association with improved outcomes. Real-world evidence (...

Automated phenotyping of mild cognitive impairment and Alzheimer's disease and related dementias using electronic health records.

International journal of medical informatics
OBJECTIVES: Unstructured and structured data in electronic health records (EHR) are a rich source of information for research and quality improvement studies. However, extracting accurate information from EHR is labor-intensive. Timely and accurate i...

A High-resolution T2WI-based Deep Learning Model for Preoperative Discrimination Between T2 and T3 Rectal Cancer: A Multicenter Study.

Academic radiology
RATIONALE AND OBJECTIVES: To construct a deep learning model (DL) based on high-resolution T2-weighted images for preoperative differentiation between T2 and T3 stage rectal cancer (RC), and to compare its performance with experienced radiologists.

Dietary and lifestyle determinants of vitamin D status in the UK Biobank Cohort study for predictive modeling.

The Journal of nutritional biochemistry
Vitamin D (VD) is involved in a wide variety of physiological processes. The high prevalence of VD deficiency in the population requires stronger preventive measures. The aim was to characterize the dietary and lifestyle determinants of VD levels in ...