AIMC Topic: Mice, Inbred C57BL

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Amino acid metabolomics and machine learning-driven assessment of future liver remnant growth after hepatectomy in livers of various backgrounds.

Journal of pharmaceutical and biomedical analysis Jul 23, 2024
Accurate assessment of future liver remnant growth after partial hepatectomy (PH) in patients with different liver backgrounds is a pressing clinical issue. Amino acid (AA) metabolism plays a crucial role in liver regeneration. In this study, we comb...
Male Mice Liver Cirrhosis Disease Models, Animal Machine Learning Animals Non-alcoholic Fatty Liver Disease Chromatography, High Pressure Liquid Tandem Mass Spectrometry Hepatectomy Liver Regeneration Mice, Inbred C57BL Metabolomics Liver Amino Acids
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Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks.

Scientific reports Jul 10, 2024
Assessment of spatial learning abilities is central to behavioral neuroscience and a useful tool for animal model validation and drug development. However, biases introduced by the apparatus, environment, or experimentalist represent a critical chall...
Behavior, Animal Maze Learning Mice Disease Models, Animal Mice, Inbred C57BL Alzheimer Disease Neural Networks, Computer Female Animals Spatial Learning Male
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Machine-Learning-Guided Peptide Drug Discovery: Development of GLP-1 Receptor Agonists with Improved Drug Properties.

Journal of medicinal chemistry Jul 8, 2024
Peptide-based drug discovery has surged with the development of peptide hormone-derived analogs for the treatment of diabetes and obesity. Machine learning (ML)-enabled quantitative structure-activity relationship (QSAR) approaches have shown great p...
Quantitative Structure-Activity Relationship Mice, Obese Glucagon-Like Peptide-1 Receptor Agonists Drug Discovery Mice Mice, Inbred C57BL Obesity Humans Machine Learning Animals Male Peptides
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A deep-learning-based threshold-free method for automated analysis of rodent behavior in the forced swim test and tail suspension test.

Journal of neuroscience methods Jul 1, 2024
BACKGROUND: The forced swim test (FST) and tail suspension test (TST) are widely used to assess depressive-like behaviors in animals. Immobility time is used as an important parameter in both FST and TST. Traditional methods for analyzing FST and TST...
Animals Mice, Inbred C57BL Video Recording Swimming Behavior, Animal Hindlimb Suspension Male Deep Learning Depression Mice
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Identification of immune-related genes and small-molecule drugs in hypertension-induced left ventricular hypertrophy based on machine learning algorithms and molecular docking.

Frontiers in immunology Jun 27, 2024
BACKGROUND: Left ventricular hypertrophy (LVH) is a common consequence of hypertension and can lead to heart failure. The immune response plays an important role in hypertensive LVH; however, there is no comprehensive method to investigate the mechan...
Gene Expression Profiling Machine Learning Disease Models, Animal Gene Regulatory Networks Animals Mice, Inbred C57BL Mice Male Hypertrophy, Left Ventricular Hypertension Molecular Docking Simulation
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Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning.

Frontiers in immunology Jun 27, 2024
BACKGROUND: Acetaminophen (APAP) is commonly used as an antipyretic analgesic. However, acetaminophen overdose may contribute to liver injury and even liver failure. Acetaminophen-induced liver injury (AILI) is closely related to mitochondrial oxidat...
Mice, Inbred C57BL Liver Copper Protein Interaction Maps Machine Learning Chemical and Drug Induced Liver Injury Acetaminophen Mice Animals Computational Biology Male Disease Models, Animal Gene Expression Profiling Transcriptome
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Biohybrid microrobots regulate colonic cytokines and the epithelium barrier in inflammatory bowel disease.

Science robotics Jun 26, 2024
Cytokines have been identified as key contributors to the development of inflammatory bowel disease (IBD), yet conventional treatments often prove inadequate and carry substantial side effects. Here, we present an innovative biohybrid robotic system,...
Macrophages Cytokines Inflammatory Bowel Diseases Animals Male Colon Mice Nanoparticles Humans Equipment Design Epithelium Disease Models, Animal Mice, Inbred C57BL Intestinal Mucosa Robotics
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Unraveling the genetic and molecular landscape of sepsis and acute kidney injury: A comprehensive GWAS and machine learning approach.

International immunopharmacology Jun 8, 2024
OBJECTIVES: This study aimed to explore the underlying mechanisms of sepsis and acute kidney injury (AKI), including sepsis-associated AKI (SA-AKI), a frequent complication in critically ill sepsis patients.
Disease Models, Animal Mice, Inbred C57BL Prognosis Acute Kidney Injury Animals Male Mice Genetic Predisposition to Disease Polymorphism, Single Nucleotide Sepsis Genome-Wide Association Study Humans Machine Learning
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Integrated biomarker profiling for predicting the response of type 2 diabetes to metformin.

Diabetes, obesity & metabolism Jun 3, 2024
AIM: To explore biomarkers that can predict the response of type 2 diabetes (T2D) patients to metformin at an early stage to provide better treatment for T2D.
Metabolomics Metformin Male Middle Aged Diabetes Mellitus, Type 2 Mice Insulin Resistance Hypoglycemic Agents Treatment Outcome Mice, Inbred C57BL Biomarkers Female Aged Animals Humans Machine Learning
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OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data.

Cellular oncology (Dordrecht, Netherlands) May 28, 2024
PURPOSE: Pancreatic Ductal Adenocarcinoma (PDAC) remains a challenging disease due to its complex biology and aggressive behavior with an urgent need for efficient therapeutic strategies. To assess therapy response, pre-clinical PDAC organoid-based m...
Carcinoma, Pancreatic Ductal Coculture Techniques Caproates Mice, Inbred C57BL Cell Survival Pancreatic Neoplasms Kinetics Antineoplastic Agents Deep Learning Time Factors Mice Antibodies, Monoclonal, Humanized Humans Animals Leukocytes, Mononuclear
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