AIMC Topic: Mice

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Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells.

Pakistan journal of biological sciences : PJBS Jan 1, 2018
BACKGROUND AND OBJECTIVE: Zerumbone has been reported to exert anti-inflammatory, anti-ulcer and anti-hyperglycemic effects but the specific mechanism through which zerumbone exerts its anti-inflammatory action through inhibiting reactive oxygen spec...
Enzyme Precursors Reactive Oxygen Species Inflammation Immune System Neutrophils Luminescence Immunomodulation Dose-Response Relationship, Drug Sesquiterpenes Plant Preparations Respiratory Burst Tetradecanoylphorbol Acetate Humans Inhibitory Concentration 50 Macrophages Animals Mice
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Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis.

Current molecular medicine Jan 1, 2018
PURPOSE: Protein sumoylation is a well established regulatory mechanism that regulates chromatin structure and dynamics, cell proliferation and differentiation, stress response and cell apoptosis. In the vertebrate eye, we and others have shown that ...
Lens, Crystalline Ultraviolet Rays Glucose Oxidase Gene Expression Regulation, Enzymologic Ubiquitin-Activating Enzymes Animals Sumoylation Mice RNA, Messenger Cataract
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Machine-Learning Prediction of Drug-Induced Cardiac Arrhythmia: Analysis of Gene Expression and Clustering.

Critical reviews in biomedical engineering Jan 1, 2018
A marked delay in the electrical repolarization of heart ventricles is characterized by prolongation of the Q-T wave (QT) interval on a surface electrocardiogram. Such a delay can lead to potentially life-threatening cardiac arrhythmia (torsades de p...
Animals Male Drug Design Gene Expression Profiling Mice Machine Learning Female Reproducibility of Results Sensitivity and Specificity Signal Processing, Computer-Assisted Heart Drug Evaluation, Preclinical Heart Ventricles Arrhythmias, Cardiac Rats Electrocardiography Support Vector Machine Cluster Analysis Humans MAP Kinase Signaling System Torsades de Pointes Gene Expression Regulation Clinical Trials as Topic False Positive Reactions
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[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Jan 1, 2018
　During the preclinical research period of drug development, animal testing is widely used to help screen out a drug's dangerous side effects. However, it remains difficult to predict side effects within the central nervous system. Here, we introduce...
Drug Discovery Mice Seizures Drug Evaluation, Preclinical Drug-Related Side Effects and Adverse Reactions Humans Diphenhydramine Machine Learning Theophylline Forecasting Enoxacin Animals Strychnine
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Single subject transcriptome analysis to identify functionally signed gene set or pathway activity.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Jan 1, 2018
Analysis of single-subject transcriptome response data is an unmet need of precision medicine, made challenging by the high dimension, dynamic nature and difficulty in extracting meaningful signals from biological or stochastic noise. We have propose...
Male Gene Expression Profiling Gene Regulatory Networks Mice Computational Biology Humans Precision Medicine Female Animals Databases, Genetic Oligonucleotide Array Sequence Analysis Mice, Inbred C57BL Mice, Inbred Strains Diet, High-Fat Mice, 129 Strain Gene Ontology Mice, Inbred DBA Mice, Inbred NZB
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[Effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides on non-alcoholic fatty liver disease induced by high-fat diet in mice].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2017
To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. A total of 50 male C57 mice were randomly and equally divided in...
Lacticaseibacillus paracasei Animals Liver Diet, High-Fat Probiotics Non-alcoholic Fatty Liver Disease Male Oligosaccharides Mice Rats Rats, Sprague-Dawley
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[Alpinetin promotes the binding of PPAR and methyltransferase].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology Dec 1, 2017
Objective To screen the nucleus located-methyltransferase in murine macrophages (RAW246.7 cells) after peroxisome proliferator-activated receptors (PPAR) is activated by alpinetin so as to prove the epigenetic modification effect of alpinetin. Method...
Peroxisome Proliferator-Activated Receptors Cells, Cultured Computational Biology Animals Mice Flavanones Cell Nucleus Methyltransferases Anilides
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Polysaccharides extracted from the roots of Bupleurum chinense DC modulates macrophage functions.

Chinese journal of natural medicines Dec 1, 2017
The present study aimed to investigate the effects of polysaccharides extracted from Bupleurum chinense DC (BCPs) on macrophage functions. In the in vivo experiment, 1 mL of 5% sodium thioglycollate was injected into the abdomen of the mice on Day 0 ...
Plant Roots Phagocytosis Immunologic Factors Polysaccharides Plants, Medicinal Immunomodulation Bupleurum Mice Macrophages Chemotaxis Cytokines Animals Plant Extracts Nitric Oxide Mice, Inbred BALB C
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Microwave-assisted One-pot Efficient Synthesis of Functionalized 2-Oxo-2-phenylethylidenes-linked 2-Oxobenzo[1,4]oxazines and 2-Oxoquino[1,4]oxalines: Synthetic Applications, Antioxidant Activity, SAR and Cytotoxic Studies.

Acta chimica Slovenica Dec 1, 2017
A microwave-assisted, environmentally benign green protocol for the synthesis of functionalized (Z)-3-(2-oxo-2-phenylethylidene)-3, 4-dihydro-2H-benzo[b][1,4]oxazin-2-ones (11a-n) in excellent yields (upto 97%) and (Z)-3-(2-oxo-2-phenylethylidene)-3,...
Quinoxalines Animals Antineoplastic Agents Mice Antioxidants Structure-Activity Relationship Oxazines 3T3 Cells Microwaves
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Mirnovo: genome-free prediction of microRNAs from small RNA sequencing data and single-cells using decision forests.

Nucleic acids research Dec 1, 2017
The discovery of microRNAs (miRNAs) remains an important problem, particularly given the growth of high-throughput sequencing, cell sorting and single cell biology. While a large number of miRNAs have already been annotated, there may well be large n...
Mice Genomics Sequence Analysis, RNA Algorithms MicroRNAs Animals High-Throughput Nucleotide Sequencing Gene Expression Profiling RNA, Small Untranslated Single-Cell Analysis Ribonuclease III RNA, Plant Humans Machine Learning Software
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