AIMC Topic: Multicenter Studies as Topic

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Early warning and stratification of the elderly cardiopulmonary dysfunction-related diseases: multicentre prospective study protocol.

BMJ open
INTRODUCTION: In China, there is a lack of standardised clinical imaging databases for multidimensional evaluation of cardiopulmonary diseases. To address this gap, this study protocol launched a project to build a clinical imaging technology integra...

A multi-site randomized clinical trial of socially assistive robots on engaging older adults with cognitive impairment residing in long-term care settings: A protocol paper.

Contemporary clinical trials
Apathy is common in persons with dementias, especially those in long-term care facilities (LTCs). Few pharmacologic options exist; a major strategy is to foster engagement in social, physical, and cognitive activities, but requires extensive personne...

Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial.

BMJ open
INTRODUCTION: Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, Kidney Dise...

Deep graph learning of multimodal brain networks defines treatment-predictive signatures in major depression.

Molecular psychiatry
Major depressive disorder (MDD) presents a substantial health burden with low treatment response rates. Predicting antidepressant efficacy is challenging due to MDD's complex and varied neuropathology. Identifying biomarkers for antidepressant treatm...

A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherapy: the ASTuTE protocol.

BMC cancer
BACKGROUND: Androgen deprivation therapy (ADT) improves outcomes in men undergoing definitive radiotherapy for prostate cancer but carries significant toxicities. Clinical parameters alone are insufficient to accurately identify patients who will der...