Neural-tumor electrophysiology-marked by pathological membrane potentials and ion channel dysregulation-emerges as actionable targets to curb tumor aggression. Yet, how neural-driven bioelectrical crosstalk dynamically regulates tumors within functio...
Early detection of lung cancer is crucial for improving patient outcomes. However, accurately diagnosing invasive pulmonary nodules and predicting tumor invasiveness remain major clinical challenges. Given the established role of immune dysfunction i...
BACKGROUND: Preoperative endometrial cancer (EC) diagnosis often depends on radiologists' expertise, which introduces subjectivity. Recent studies have explored radiomics-based machine learning (ML) models for detecting myometrial invasion (MI), but ...
PURPOSE: To evaluate differences in clinical outcomes, treatments received, recurrence, and sociodemographic characteristics in patients with triple-negative breast cancer (TNBC) classified as invasive lobular carcinoma (TNBC-ILC) or invasive carcino...
Accurate assessment of thyroid cartilage invasion is crucial for treatment decision-making and prognosis evaluation in laryngeal squamous cell carcinoma (LSCC). This study aimed to compare the performance of the radiomics and deep learning (DL) model...
OBJECTIVE: To develop and validate an integrated 2.5D deep learning (DL) and Radiomics model using gadoxetic acid-enhanced MRI hepatobiliary phase (HBP) images combined with clinical features for preoperative prediction of microvascular invasion (MVI...
OBJECTIVE: Microvascular invasion (MVI) is of great significance for the individualized treatment of hepatocellular carcinoma (HCC) and preoperative noninvasive prediction of MVI is still an urgent clinical problem. To explore the effects of differen...
Visceral pleural invasion (VPI) is a critical prognostic factor in early-stage non-small-cell lung cancer (NSCLC), significantly affecting patient outcomes. Conventional computed tomography (CT) often fails to diagnose VPI accurately. This retrospect...
Medical science monitor : international medical journal of experimental and clinical research
Oct 10, 2025
BACKGROUND Perineural invasion (PNI) is strongly associated with poor clinical outcomes in colorectal cancer (CRC). However, no machine learning diagnostic model based on pathomics has been established for PNI detection in CRC. To address this issue,...
Pancreatic cancer is an aggressive disease with a dense fibrotic stroma and is often accompanied by chronic inflammation. Peritumoral inflammation is typically viewed as a reaction to nearby tumor growth. Here, we report that the inflamed pancreatic ...
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