AIMC Topic: Peptide Fragments

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Original signal amplification assay for N-Terminal pro-brain natriuretic peptide detection based on BiMoO photosensitive matrix.

Analytica chimica acta Dec 16, 2019
An original dual signal amplification immunoassay for N-Terminal pro-brain natriuretic peptide (NT-proBNP) detection is developed based on Au NPs and Zn doped CdS nanoparticles (ZnCdS) co-sensitized BiMoO nanosheet photoelectrochemical (PEC) platform...
Molybdenum Cadmium Antibodies, Immobilized Bismuth Natriuretic Peptide, Brain Limit of Detection Peptide Fragments Immunoassay Surface Plasmon Resonance Humans Reproducibility of Results Zinc Electrochemical Techniques Gold Metal Nanoparticles
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Usefulness of presepsin as diagnostic and prognostic marker of sepsis in daily clinical practice.

Journal of infection in developing countries Nov 30, 2019
INTRODUCTION: Sepsis represents a major cause of morbidity and mortality in critically ill patients. Early diagnosis and appropriate treatment have a crucial influence on survival. The aim of this study was to evaluate the diagnostic and prognostic r...
APACHE Male Lactic Acid Case-Control Studies Humans Sepsis Lipopolysaccharide Receptors Biomarkers Area Under Curve Prognosis Peptide Fragments Female
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NeuRiPP: Neural network identification of RiPP precursor peptides.

Scientific reports Sep 16, 2019
Significant progress has been made in the past few years on the computational identification of biosynthetic gene clusters (BGCs) that encode ribosomally synthesized and post-translationally modified peptides (RiPPs). This is done by identifying both...
Ribosomes Humans Neural Networks, Computer Machine Learning Software Computational Biology Protein Processing, Post-Translational Peptide Fragments Protein Biosynthesis
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Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes.

Cancer immunology research Sep 12, 2019
Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity usi...
Female Animals Male Neoplasms Epitopes, T-Lymphocyte Humans Machine Learning Algorithms Mice, Inbred C57BL Peptide Fragments Histocompatibility Antigens Class I Histocompatibility Antigens Class II T-Lymphocytes, Cytotoxic Mice Computational Biology Cancer Vaccines Antigens, Neoplasm Mice, Inbred BALB C
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Application of artificial neural network model in diagnosis of Alzheimer's disease.

BMC neurology Jul 8, 2019
BACKGROUND: Alzheimer's disease has become a public health crisis globally due to its increasing incidence. The purpose of this study was to establish an early warning model using artificial neural network (ANN) for early diagnosis of AD and to explo...
Neural Networks, Computer Biomarkers Female Aged Aged, 80 and over Humans Early Diagnosis Nerve Tissue Proteins Area Under Curve Amyloid beta-Peptides Peptide Fragments Alzheimer Disease Sensitivity and Specificity Male Case-Control Studies Trace Elements
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Artificial intelligence and machine learning for predicting acute kidney injury in severely burned patients: A proof of concept.

Burns : journal of the International Society for Burn Injuries Jun 21, 2019
BACKGROUND: Burn critical care represents a high impact population that may benefit from artificial intelligence and machine learning (ML). Acute kidney injury (AKI) recognition in burn patients could be enhanced by ML. The goal of this study was to ...
Male Middle Aged Peptide Fragments Lipocalin-2 Burns Acute Kidney Injury Female Young Adult Adult Creatinine Natriuretic Peptide, Brain Urine Proof of Concept Study Humans Artificial Intelligence Machine Learning
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Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning.

Nature methods May 27, 2019
In mass-spectrometry-based proteomics, the identification and quantification of peptides and proteins heavily rely on sequence database searching or spectral library matching. The lack of accurate predictive models for fragment ion intensities impair...
Peptide Fragments Tandem Mass Spectrometry HEK293 Cells Saccharomyces cerevisiae Drosophila melanogaster Caenorhabditis elegans Animals Deep Learning Peptide Library Proteome Databases, Protein Humans Neural Networks, Computer Software
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The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin.

BioMed research international Dec 31, 2018
The demand of tetanus antitoxin (TAT) as tetanus treatment in developing and underdeveloped countries is still great since it is relatively easy to achieve and affordable. However, there are still issues in the preparation of highly effective TAT wit...
Tetanus Antitoxin Tetanus Toxin Peptide Fragments Female Antibodies Animals Horses Male Antibody Formation Mice Tetanus Mice, Inbred ICR
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Decreased circulating catestatin levels are associated with coronary artery disease: The emerging anti-inflammatory role.

Atherosclerosis Dec 24, 2018
BACKGROUND AND AIMS: The neuropeptide catestatin (CST) is an endogenous nicotinic cholinergic antagonist that acts as pleiotropic cardiac protective hormone. This study investigated the association between CST and coronary artery disease (CAD) and th...
Severity of Illness Index Case-Control Studies Disease Models, Animal Human Umbilical Vein Endothelial Cells Peptide Fragments Anti-Inflammatory Agents Coronary Artery Disease Atherosclerosis Down-Regulation Cytokines Biomarkers Female Animals Male Peptidyl-Dipeptidase A Humans Plaque, Atherosclerotic Cells, Cultured Cell Adhesion Molecules Angiotensin-Converting Enzyme 2 Chromogranin A Mice, Knockout, ApoE
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Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis.

Disease markers Dec 16, 2018
Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP...
Lipopolysaccharide Receptors Aged, 80 and over Young Adult Humans Adult Sepsis Female Male Neutrophils Middle Aged Aged Psoriasis Procalcitonin Peptide Fragments
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