AIMC Topic: Peptide Fragments

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Serum Peroxisome Proliferator-activated Receptor Gamma Coactivator-1α Related to Myocardial Energy Expenditure in Patients With Chronic Heart Failure.

The American journal of the medical sciences Dec 7, 2018
BACKGROUND: Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) plays key roles in controlling cardiac metabolism and function. Myocardial energy expenditure (MEE) can reflect myocardial energy metabolism and cardiac function. Wh...
Energy Metabolism Echocardiography Natriuretic Peptide, Brain Humans Middle Aged Correlation of Data Female Myocardium Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Aged Peptide Fragments Male Heart Failure Ventricular Function, Left
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Serum level of interleukin-6 (IL-6) and N-terminal propeptide of procollagen type I (PINP) in patients with liver diseases.

Scandinavian journal of clinical and laboratory investigation Dec 22, 2017
INTRODUCTION: The aim of this study was to evaluate the concentration of interleukin-6 and N-terminal propeptide of procollagen type I and their relationship in liver diseases of different etiologies.
Peptide Fragments Liver Diseases Procollagen Adult Male Middle Aged Case-Control Studies ROC Curve Humans Interleukin-6 Female Aged
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Specific and intrinsic sequence patterns extracted by deep learning from intra-protein binding and non-binding peptide fragments.

Scientific reports Nov 2, 2017
The key finding in the DNA double helix model is the specific pairing or binding between nucleotides A-T and C-G, and the pairing rules are the molecule basis of genetic code. Unfortunately, no such rules have been discovered for proteins. Here we sh...
Proteins Databases, Protein Peptide Fragments Amino Acid Sequence Protein Conformation Algorithms Binding Sites Deep Learning Protein Binding
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A machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women.

Osteoarthritis and cartilage Sep 9, 2017
OBJECTIVE: Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease. Furthermore, the available diagnostic approaches have large precision errors and low...
Humans Peptide Fragments Machine Learning Biomarkers Heuristics Reproducibility of Results Female Fruit Middle Aged Overweight Arthralgia Diet Obesity Osteoarthritis, Knee Comorbidity Collagen Type I Muscle Strength Incidence Collagen Type II Quadriceps Muscle Principal Component Analysis
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The effect of percutaneous coronary revascularization on plasma N-terminal pro-B-type natriuretic peptide levels in stable coronary artery disease.

Indian heart journal Aug 16, 2017
BACKGROUND: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA).
Coronary Angiography Peptide Fragments Percutaneous Coronary Intervention Humans Coronary Artery Disease Prospective Studies Angina, Stable Male Natriuretic Peptide, Brain Biomarkers Middle Aged Female Time Factors Aged Electrocardiography Adult Follow-Up Studies
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In silico identification of milk antihypertensive di- and tripeptides involved in angiotensin I-converting enzyme inhibitory activity.

Nutrition research (New York, N.Y.) Jul 28, 2017
Identification of bioactive milk peptides could improve food technology through improved selection of food supplements with a focus on antihypertensive properties. We hypothesized that angiotensin I-converting enzyme (ACE) inhibitory activities of mi...
Dietary Supplements Antihypertensive Agents Models, Molecular Peptide Fragments Dipeptides Hydrophobic and Hydrophilic Interactions Humans Animals Molecular Docking Simulation Cattle Computational Biology Milk Proteins Protein Conformation Hydrogen Bonding Peptidyl-Dipeptidase A Proteolysis Binding Sites Expert Systems Catalytic Domain Oligopeptides Angiotensin-Converting Enzyme Inhibitors Quantitative Structure-Activity Relationship
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Immunogenicity, Vaccine Mice, Transgenic Models, Immunological Protein Refolding T-Lymphocytes, Cytotoxic Epitopes HLA-A2 Antigen Protein Stability Expert Systems Oligopeptides Reproducibility of Results Animals Computational Biology Cancer Vaccines Antigens, Neoplasm Vaccines, Synthetic Membrane Proteins Neoplasm Proteins Mice, Knockout Peptide Fragments Humans Artificial Intelligence Cells, Cultured Melanoma
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A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.

Retrovirology Dec 20, 2016
BACKGROUND: CCR5-coreceptor antagonists can be used for treating HIV-2 infected individuals. Before initiating treatment with coreceptor antagonists, viral coreceptor usage should be determined to ensure that the virus can use only the CCR5 corecepto...
Receptors, CCR5 Internet CCR5 Receptor Antagonists Genotyping Techniques HIV Envelope Protein gp120 HIV-2 Humans Support Vector Machine HIV Infections Receptors, CXCR4 Peptide Fragments Decision Support Systems, Clinical Genotype
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Cardiac Biomarkers of Low Cardiac Output Syndrome in the Postoperative Period After Congenital Heart Disease Surgery in Children.

Revista espanola de cardiologia (English ed.) Oct 27, 2016
INTRODUCTION AND OBJECTIVES: To assess the predictive value of atrial natriuretic peptide, β-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin (MR-proADM) and cardiac troponin I (cTn-I) as indicators of low cardiac output syndrome i...
Pilot Projects Child, Preschool Child Operative Time Troponin Peptide Fragments Cardiopulmonary Bypass Protein Precursors Analysis of Variance Heart Defects, Congenital Female Infant, Newborn Male Postoperative Complications Infant Humans Biomarkers Cardiac Output, Low Adrenomedullin
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Predictive value of circulating osteonectin in patients with ischemic symptomatic chronic heart failure.

Biomedical journal Feb 19, 2016
BACKGROUND: Osteonectin (OSN) plays a pivotal role in cardiac remodeling, but predictive value for OSN in ischemic chronic heart failure (CHF) has not been defined. The aim of the study was to evaluate the prognostic value of OSN for cumulative survi...
Heart Failure Natriuretic Peptide, Brain Myocardial Ischemia Osteonectin Aged Humans Male Prospective Studies Middle Aged Female Chronic Disease Peptide Fragments
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