INTRODUCTION: Heart failure (HF) is a complex clinical syndrome. Accurate risk stratification and early diagnosis of HF are challenging as its signs and symptoms are non-specific. We propose to address this global challenge by developing the STRATIFY...
Although prediction models for heart transplantation outcomes have been developed previously, a comprehensive benchmarking of survival machine learning methods for mortality prognosis in the most contemporary era of heart transplants following the 20...
BACKGROUND: Recent years have seen persistently poor prognoses for glioma patients. Therefore, exploring the molecular subtyping of gliomas, identifying novel prognostic biomarkers, and understanding the characteristics of their immune microenvironme...
BACKGROUND: Hepatocellular carcinoma (LIHC) poses a significant health challenge worldwide, primarily due to late-stage diagnosis and the limited effectiveness of current therapies. Cancer stem cells are known to play a role in tumor development, met...
Frontiers in cellular and infection microbiology
Jan 7, 2025
BACKGROUND: The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis ...
Neural networks : the official journal of the International Neural Network Society
Jan 6, 2025
Accurately predicting intracerebral hemorrhage (ICH) prognosis is a critical and indispensable step in the clinical management of patients post-ICH. Recently, integrating artificial intelligence, particularly deep learning, has significantly enhanced...
Computer methods and programs in biomedicine
Jan 6, 2025
BACKGROUND: The growing population of elderly neurocritically ill patients highlights the need for effective prognosis prediction tools. This study aims to develop and validate machine learning (ML) models for predicting 28-day mortality in intensive...
INTRODUCTION: Cardiac arrest (CA), characterized by its heterogeneity, poses challenges in patient management. This study aimed to identify clinical subphenotypes in CA patients to aid in patient classification, prognosis assessment, and treatment de...
OBJECTIVES: Spingosine-1-phosphate (S1P) and ceramides are bioactive sphingolipids that influence cancer cell fate. Anti-ceramide antibodies might inhibit the effects of ceramide. The aim of this study was to assess the potential role of circulating ...
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...