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Machine learning and complex network analysis of drug effects on neuronal microelectrode biosensor data.
Scientific reports
Apr 30, 2025
Biosensors, such as microelectrode arrays that record in vitro neuronal activity, provide powerful platforms for studying neuroactive substances. This study presents a machine learning workflow to analyze drug-induced changes in neuronal biosensor da...
Identification of pivotal genes and regulatory networks associated with SAH based on multi-omics analysis and machine learning.
Scientific reports
Apr 24, 2025
Subarachnoid hemorrhage (SAH) is a disease with high mortality and morbidity, and its pathophysiology is complex but poorly understood. To investigate the potential therapeutic targets post-SAH, the SAH-related feature genes were screened by the comb...
Nuciferine activates intestinal TAS2R46 to attenuate metabolic disorders and hyperlipidemia via hepatic VLDL regulation.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 22, 2025
BACKGROUND: Dysregulated blood lipid metabolism, a primary driver of hyperlipidemia, is closely associated with excessive very low-density lipoprotein (VLDL) synthesis and secretion. Nuciferine, a bioactive compound isolated from lotus leaves, demons...
Integrating WGCNA and SVM-RFE identifies hub molecular biomarkers driving ischemic stroke progression.
Neurological research
Apr 22, 2025
BACKGROUND: Stroke is the second most common cause of death worldwide and the leading cause of long-term severe disability with neurological impairment worsening within hours after stroke onset and being especially involved with motor function. So fa...
Repetitive training enhances the pattern recognition capability of cultured neural networks.
PLoS computational biology
Apr 22, 2025
Cultured neural networks in vitro have demonstrated the biocomputing capability to recognize patterns. However, the underlying mechanisms behind information processing and pattern recognition remain less understood. Here, we developed an in vitro neu...
Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 21, 2025
BACKGROUND: Jiedu Sangen Decoction (JSD) is widely used in the treatment of colorectal cancer (CRC) patients in southern China due to its good clinical efficacy, but the effective active ingredients are still unknown.
Gui-Pi-Tang Defers Skeletal Muscle and Cardiac Muscle Aging by Promoting Mitochondrial Remodeling.
Drug design, development and therapy
Apr 21, 2025
PURPOSE: To determine whether Gui-Pi-Tang (GPT) has protective effects on skeletal muscle and cardiac muscle in aged mice.
Molecular features and diagnostic modeling of synovium- and IPFP-derived OA macrophages in the inflammatory microenvironment via scRNA-seq and machine learning.
Journal of orthopaedic surgery and research
Apr 17, 2025
BACKGROUND: Osteoarthritis (OA) is the leading cause of degenerative joint disease, with total joint replacement as the only definitive cure. However, no disease-modifying therapy is currently available. Inflammation and fibrosis in the infrapatellar...
Identification of cancerous tissues based on residual neural network.
Scientific reports
Apr 17, 2025
The identification of cancerous tissues remains challenging due to the complexity of experimental methods and low identification accuracy rates. Therefore, this paper proposes a rapid identification method. We introduce a new theoretical transmission...
ShenJiaoLingCao decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism.
Journal of ethnopharmacology
Apr 16, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: ShenJiaoLingCao Decoction (SJLCD) is derived from the classic Chinese medicine prescription, which consists of ten kinds of herbs. In China, SJLCD has been used as an immunomodulator in clinical practice for more than ...
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