AIMC Topic: Rats

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In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS.

Journal of applied toxicology : JAT Jul 13, 2020
Electronic nicotine delivery systems (ENDS) are regulated tobacco products and often contain flavor compounds. Given the concern of increased use and the appeal of ENDS by young people, evaluating the potential of flavors to induce DNA damage is impo...
Risk Assessment Mice Rats Cell Line Phosphorylation Humans Machine Learning Biomarkers Animals Quantitative Structure-Activity Relationship Mutagenicity Tests Histones Electronic Nicotine Delivery Systems Consumer Product Safety Models, Molecular DNA Damage Flow Cytometry Tumor Suppressor Protein p53 Flavoring Agents
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Single-Cell Classification Using Mass Spectrometry through Interpretable Machine Learning.

Analytical chemistry Jun 25, 2020
The brain consists of organized ensembles of cells that exhibit distinct morphologies, cellular connectivity, and dynamic biochemistries that control the executive functions of an organism. However, the relationships between chemical heterogeneity, c...
Machine Learning Animals ROC Curve Cerebellum Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Hippocampus Single-Cell Analysis Rats Mass Spectrometry Principal Component Analysis Area Under Curve
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Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.

Molecular pharmaceutics Jun 12, 2020
The in vitro-in vivo extrapolation (IVIVE) approach for predicting total plasma clearance (CL) has been widely used to rank order compounds early in discovery. More recently, a computational machine learning approach utilizing physicochemical descrip...
Humans Machine Learning Models, Biological Rats, Sprague-Dawley Madin Darby Canine Kidney Cells Liver Microsomes, Liver Blood Proteins Hepatocytes Pharmaceutical Preparations Permeability Animals Dogs Pharmacokinetics Male Administration, Intravenous Protein Binding Plasma Rats Metabolic Clearance Rate Membranes, Artificial
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Machine learning-based design strategy for 3D printable bioink: elastic modulus and yield stress determine printability.

Biofabrication May 28, 2020
Although three-dimensional (3D) bioprinting technology is rapidly developing, the design strategies for biocompatible 3D-printable bioinks remain a challenge. In this study, we developed a machine learning-based method to design 3D-printable bioink u...
Ink Elastic Modulus Bioprinting Rheology Collagen Stress, Mechanical Humans Machine Learning Animals Cattle Rats Printing, Three-Dimensional Hydrogels
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Results of Green Indocyanine in the Use of the R1T1 Robot as Aid in the Pre-operative Process of Hepatic Organ Transplant: Experiment in Wistar Rats.

Transplantation proceedings May 24, 2020
Since the beginning of the history of transplants, numerous difficulties have been faced in the effective implementation of this therapeutic practice, especially with regard to the transplantation of solid organs and their teaching and training, toge...
Liver Function Tests Rats Transplants Liver Humans Robotics Animals Male Liver Transplantation Rats, Wistar Indocyanine Green
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Generation of Scale-Invariant Sequential Activity in Linear Recurrent Networks.

Neural computation May 20, 2020
Sequential neural activity has been observed in many parts of the brain and has been proposed as a neural mechanism for memory. The natural world expresses temporal relationships at a wide range of scales. Because we cannot know the relevant scales a...
Animals Memory Rats Neural Networks, Computer Exercise Test Brain Neurons Linear Models
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Bioinspired Soft Microrobots with Precise Magneto-Collective Control for Microvascular Thrombolysis.

Advanced materials (Deerfield Beach, Fla.) May 20, 2020
New-era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, and precise locomotion control in a collective manne...
Coculture Techniques Cell Survival Magnetic Fields Robotics Umbilical Cord Fibrinolytic Agents Humans Thromboembolism Metal Nanoparticles Animals Magnetosomes Mesenchymal Stem Cells Rats Biocompatible Materials Neutrophils Biomimetics Ferric Compounds Tissue Plasminogen Activator
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In Silico Prediction of Intestinal Permeability by Hierarchical Support Vector Regression.

International journal of molecular sciences May 19, 2020
The vast majority of marketed drugs are orally administrated. As such, drug absorption is one of the important drug metabolism and pharmacokinetics parameters that should be assessed in the process of drug discovery and development. A nonlinear quant...
Regression Analysis Permeability Humans Reproducibility of Results Computer Simulation Animals Intestines Rats Support Vector Machine
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AxoNet: A deep learning-based tool to count retinal ganglion cell axons.

Scientific reports May 15, 2020
In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal models of glaucoma. We adapted deep learning to regress pixelwise axon count de...
Glaucoma Software Algorithms Female Reproducibility of Results Animals Male Deep Learning Computational Biology Rats Axons Disease Models, Animal Retinal Ganglion Cells Optic Nerve Optic Nerve Diseases Models, Biological Disease Susceptibility
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Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation.

Scientific reports May 5, 2020
Restoration of the communication between brain circuitry is a crucial step in the recovery of brain damage induced by traumatic injuries or neurological insults. In this work we present a study of real-time unidirectional communication between a spik...
Neurotransmitter Agents Synapsins Immunohistochemistry Neural Networks, Computer Cerebral Cortex Cells, Cultured Microscopy, Fluorescence Electrophysiology Brain Electrodes, Implanted Light Computer Simulation Optogenetics Neurons Humans Animals In Vitro Techniques Video Recording Rats Models, Neurological Action Potentials Equipment Design
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