Phytomedicine : international journal of phytotherapy and phytopharmacology
Oct 15, 2025
BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with rising prevalence and limited therapies. Zhilining Formula (ZLN), a Traditional Chinese Medicine (TCM), shows clinical efficacy in UC, yet its core material b...
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC), yet resistance limits its efficacy. The Hedgehog (HH) signaling pathway contributes to drug resistance by maintaining HCC stem cell characteristics, but its role at the ...
Journal of chemical information and modeling
Oct 13, 2025
β-Arrestins (βarr1 and βarr2) are key transducers of G protein-coupled receptor (GPCR) signaling, orchestrating both shared and isoform-specific intracellular pathways. Phosphorylation of the receptor C-terminal tail by GPCR kinases encodes regulator...
Type 2 diabetes mellitus (T2DM) is a severe metabolic disorder in which pancreatic injury plays a pivotal role in disease progression. Tanshinone IIA (TanIIA), a bioactive compound extracted from Salvia miltiorrhiza, has shown therapeutic potential i...
BACKGROUND: Ovarian cancer (OC) poses a significant public health challenge due to its dismal prognosis and low survival rates. However, the mechanism of OC development remains unclear.
BACKGROUND: Chronic allergic rhinitis and asthma syndrome (CARAS) is a comorbid inflammatory condition affecting both upper and lower airways, with limited treatment options. Artesunate (ART), a derivative of artemisinin, has shown anti-inflammatory ...
Endometriosis (EMs) is a gynecological disorder characterized by chronic inflammation and an aberrant immune microenvironment. In this study, we integrated the GSE6364 dataset from the GEO database to identify differentially expressed genes, and appl...
Stroke remains a leading cause of disability due to the brain's limited ability to regenerate damaged neural circuits. Here, we show that local transplantation of iPSC-derived neural progenitor cells (NPCs) improves brain repair and long-term functio...
Environmental stress contributes to the development of depression through neuro-immune interactions, yet the underlying molecular mechanisms and associated clinical diagnostic biomarkers remain unclear. We established a psychosocial stress mouse mode...
Tendon injury is a common and challenging clinical problem, and its healing process involves complex cellular and biological factors. Therefore, this study aims to reveal the mechanism of tendon healing and provide theoretical basis for clinical trea...
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