AIMC Topic: Solubility

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FABRICATION AND EVALUATION OF SMART NANOCRYSTALS OF ARTEMISININ FOR ANTIMALARIAL AND ANTIBACTERIAL EFFICACY.

African journal of traditional, complementary, and alternative medicines : AJTCAM Nov 23, 2016
BACKGROUND: Nanocrystals have the potential to substantially increase dissolution rate, solubility with subsequent enhanced bioavailability via the oral route of a range of poor water soluble drugs. Regardless of other issues, scale up of the batch s...
Plasmodium falciparum Anti-Bacterial Agents Drug Stability Drug Evaluation, Preclinical Microbial Sensitivity Tests Antimalarials Nanoparticles Drug Compounding Escherichia coli Solubility Artemisinins Shigella
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A Practical Framework Toward Prediction of Breaking Force and Disintegration of Tablet Formulations Using Machine Learning Tools.

Journal of pharmaceutical sciences Oct 27, 2016
Enabling the paradigm of quality by design requires the ability to quantitatively correlate material properties and process variables to measureable product performance attributes. Conventional, quality-by-test methods for determining tablet breaking...
Drug Compounding Ultrasonics Excipients Hardness Models, Chemical Machine Learning Tablets Particle Size Solubility
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Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.

Journal of pharmaceutical sciences Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
Drug Compounding Surface Properties Organoplatinum Compounds Apoptosis Cell Survival Particle Size Molecular Structure Humans Liposomes Antineoplastic Agents Drug Stability Cell Line, Tumor Drug Storage Chromatography, High Pressure Liquid Solubility
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Modified citrus pectin stops progression of liver fibrosis by inhibiting galectin-3 and inducing apoptosis of stellate cells.

Canadian journal of physiology and pharmacology Dec 16, 2015
Modified citrus pectin (MCP) is a pH modified form of the dietary soluble citrus peel fiber known as pectin. The current study aims at testing its effect on liver fibrosis progression. Rats were injected with CCl4 (1 mL/kg, 40% v/v, i.p., twice a wee...
Apoptosis Dietary Supplements Liver Galectin 3 Dietary Fiber Lipid Peroxidation Fruit Hepatic Stellate Cells Hydrogen-Ion Concentration Disease Progression Oxidative Stress Antioxidants Pectins Solubility Rats, Sprague-Dawley Liver Cirrhosis, Experimental Hot Temperature Biomarkers Citrus Animals Carbon Tetrachloride Male
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Prediction Enhancement of Residue Real-Value Relative Accessible Surface Area in Transmembrane Helical Proteins by Solving the Output Preference Problem of Machine Learning-Based Predictors.

Journal of chemical information and modeling Oct 20, 2015
The α-helical transmembrane proteins constitute 25% of the entire human proteome space and are difficult targets in high-resolution wet-lab structural studies, calling for accurate computational predictors. We present a novel sequence-based method ca...
Animals Membrane Proteins Molecular Sequence Data Databases, Protein Amino Acid Sequence Protein Structure, Quaternary Humans Sequence Alignment Solubility Machine Learning Succinate Dehydrogenase Solvents Wolinella Protein Structure, Secondary Models, Chemical Bacterial Proteins
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Predicting Melting Points of Organic Molecules: Applications to Aqueous Solubility Prediction Using the General Solubility Equation.

Molecular informatics Jul 20, 2015
In this work we make predictions of several important molecular properties of academic and industrial importance to seek answers to two questions: 1) Can we apply efficient machine learning techniques, using inexpensive descriptors, to predict meltin...
Freezing Machine Learning Models, Chemical Solubility Databases, Chemical
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Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Neural Networks, Computer Lipids Drug Carriers Models, Chemical Polymers Kinetics Algorithms Computer Simulation Nanoparticles Particle Size Poloxamer Polysorbates Surface Properties Calcium Channel Blockers Chemistry, Pharmaceutical Delayed-Action Preparations Verapamil Solubility Nanomedicine Technology, Pharmaceutical
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Measurement and ANN prediction of pH-dependent solubility of nitrogen-heterocyclic compounds.

Chemosphere May 15, 2015
Based on the solubility of 25 nitrogen-heterocyclic compounds (NHCs) measured by saturation shake-flask method, artificial neural network (ANN) was employed to the study of the quantitative relationship between the structure and pH-dependent solubili...
Quantitative Structure-Activity Relationship Heterocyclic Compounds Neural Networks, Computer Water Nitrogen Models, Theoretical Hydrogen-Ion Concentration Environmental Pollutants Solubility
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A nanoparticulate drug-delivery system for glaucocalyxin A: formulation, characterization, increased in vitro, and vivo antitumor activity.

Drug delivery Feb 26, 2015
Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined...
Drug Delivery Systems Animals Neoplasms Mice Suspensions Nanoparticles Solubility Calorimetry, Differential Scanning Diterpenes, Kaurane
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Refining in silico simulation to study digestion parameters affecting the bioaccessibility of lipophilic nutrients and micronutrients.

Food & function Oct 23, 2014
Despite the considerable number of in vivo and in vitro studies on the digestive fate of lipophilic nutrients, micronutrients, and bioactives, the effects of the structure and composition of foods on the physicochemical mechanisms of luminal digestio...
Dietary Fats Gastric Juice Triolein Viscosity Triglycerides Intestinal Absorption Lipolysis Models, Biological Caprylates Solubility Vitamin A Bile Acids and Salts Chemical Phenomena Computer Simulation Digestion Animals Hydrophobic and Hydrophilic Interactions Computational Biology Expert Systems Food Analysis Humans
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