AIMC Topic: Tumor Necrosis Factor-alpha

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Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.

Scientific reports Feb 9, 2021
Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore li...
Artificial Intelligence Tumor Necrosis Factor-alpha Models, Neurological Injections, Spinal Spinal Cord Injuries Receptors, Tumor Necrosis Factor, Type I Rats, Long-Evans Female Animals Recombinant Proteins Rats Disease Models, Animal
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Association of a Serum Protein Signature With Rheumatoid Arthritis Development.

Arthritis & rheumatology (Hoboken, N.J.) Nov 10, 2020
OBJECTIVE: The pathophysiologic events that precede the onset of rheumatoid arthritis (RA) remain incompletely understood. This study was undertaken to identify changes in the serum proteome that precede the onset of RA, with the aim of providing new...
Calreticulin Toll-Like Receptor 2 Ficolins Young Adult Anti-Citrullinated Protein Antibodies Humans Adult Interleukin-1 Machine Learning Male Rheumatoid Factor Tumor Necrosis Factor-alpha Middle Aged Asymptomatic Diseases Adolescent Female Disease Progression Lectins Aged Arthritis, Rheumatoid Proteomics Indians, North American Longitudinal Studies
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Antioxidant and Anti-inflammatory Diagnostic Biomarkers in Multiple Sclerosis: A Machine Learning Study.

Molecular neurobiology Jan 22, 2020
An imbalance of inflammatory/anti-inflammatory and oxidant/antioxidant molecules has been implicated in the demyelination and axonal damage in multiple sclerosis (MS). The current study aimed to evaluate the plasma levels of tumor necrosis factor (TN...
Neural Networks, Computer Tumor Necrosis Factor-alpha Biomarkers Female Adult Humans Nitric Oxide Inflammation Support Vector Machine Oxidation-Reduction Sulfhydryl Compounds Sensitivity and Specificity Male Middle Aged Oxidative Stress Antioxidants Multiple Sclerosis Adiponectin Advanced Oxidation Protein Products Nitrosative Stress Receptors, Tumor Necrosis Factor
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Novel Descriptors and Digital Signal Processing- Based Method for Protein Sequence Activity Relationship Study.

International journal of molecular sciences Nov 11, 2019
The work aiming to unravel the correlation between protein sequence and function in the absence of structural information can be highly rewarding. We present a new way of considering descriptors from the amino acids index database for modeling and pr...
Epoxide Hydrolases Glucagon-Like Peptide-2 Receptor Humans Machine Learning Tumor Necrosis Factor-alpha Animals Cytochrome P-450 Enzyme System Catalytic Domain Quantitative Structure-Activity Relationship Sequence Analysis, Protein
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Machine Learning to Predict Anti-Tumor Necrosis Factor Drug Responses of Rheumatoid Arthritis Patients by Integrating Clinical and Genetic Markers.

Arthritis & rheumatology (Hoboken, N.J.) Nov 4, 2019
OBJECTIVE: Accurate prediction of treatment responses in rheumatoid arthritis (RA) patients can provide valuable information on effective drug selection. Anti-tumor necrosis factor (anti-TNF) drugs are an important second-line treatment after methotr...
Antirheumatic Agents Normal Distribution Etanercept Certolizumab Pegol Arthritis, Rheumatoid Polymorphism, Single Nucleotide Treatment Outcome Regression Analysis Predictive Value of Tests Infliximab Genetic Markers Methotrexate Adalimumab Outcome Assessment, Health Care Female Reproducibility of Results Male Middle Aged Severity of Illness Index Humans Machine Learning Tumor Necrosis Factor-alpha
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Sorghum Fermented by NK Enhances Inhibition of Vascular Inflammation in TNF-α-stimulated Human Aortic Smooth Muscle Cells.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition Jun 25, 2019
Sorghum bicolor L. Moench is widely grown all over the world for food and feed. The effects of sorghum extracts on general inflammation have been previously studied, but its anti-vascular inflammatory effects are unknown. Therefore, this study inve...
Myocytes, Smooth Muscle Humans Tumor Necrosis Factor-alpha Sorghum Cells, Cultured Inflammation Aspergillus oryzae
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Pre-Treatment Biomarkers of Anti-Tumour Necrosis Factor Therapy Response in Crohn's Disease-A Systematic Review and Gene Ontology Analysis.

Cells May 28, 2019
The most prominent treatment for the serious cases of Crohn's disease (CD) are biological tumour necrosis factor (TNF) inhibitors. Unfortunately, therapy nonresponse is still a serious issue in ~1/3 of CD patients. Accurate prediction of responsivene...
Genome, Human Gene Ontology Tumor Necrosis Factor-alpha Biomarkers Humans Polymorphism, Single Nucleotide Crohn Disease RNA
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Neuroprotective role of 6-Gingerol-rich fraction of Zingiber officinale (Ginger) against acrylonitrile-induced neurotoxicity in male Wistar rats.

Journal of basic and clinical physiology and pharmacology Dec 22, 2018
Background Acrylonitrile (AN) is a neurotoxin that is widely used to manufacture synthetic fibres, plastics and beverage containers. Recently, we reported the ameliorative role of 6-gingerol-rich fraction from Zingiber officinale (Ginger, GRF) on the...
Male Glutathione Tumor Necrosis Factor-alpha Oxidative Stress Rats Antioxidants Interleukin-6 Acrylonitrile Nitric Oxide Plant Extracts Animals Cerebral Cortex Glutathione Transferase Malondialdehyde Neuroprotection Rats, Wistar Fatty Alcohols Superoxide Dismutase Catalase Zingiber officinale Inflammation Lipid Peroxidation Catechols Glutathione Peroxidase
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Factors involved in phenoconversion of CYP3A using 4β-hydroxycholesterol in stable kidney transplant recipients.

Pharmacological reports : PR Dec 15, 2018
BACKGROUND: Phenoconversion is a phenomenon whereby some genotypic extensive metabolizers transiently exhibit drug metabolizing enzyme activity at similar level as that of poor metabolizers. Renal failure is known to decrease CYP3A activity in humans...
Cytochrome P-450 CYP3A Hydroxycholesterols Indican Middle Aged Genotype Female Alleles Aged Parathyroid Hormone Humans Young Adult Polymorphism, Genetic Tumor Necrosis Factor-alpha Adult Kidney Transplantation Male Interleukin-6
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Evaluation of Effect of Glucosamine-Chondroitin Sulfate, Tramadol, and Sodium Hyaluronic Acid on Expression of Cytokine Levels in Internal Derangement of Temporomandibular Joint.

The journal of contemporary dental practice Dec 1, 2018
AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1β, TNF-α, and PGE2.
Interleukin-6 Biomarkers Female Male Dinoprostone Treatment Outcome Interleukin-1beta Temporomandibular Joint Disorders Facial Pain Hyaluronic Acid Humans Tumor Necrosis Factor-alpha Inflammation Mediators Tramadol Chondroitin Sulfates Glucosamine
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