AIMC Topic: Actins

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SHIFT: speedy histological-to-immunofluorescent translation of a tumor signature enabled by deep learning.

Scientific reports Oct 15, 2020
Spatially-resolved molecular profiling by immunostaining tissue sections is a key feature in cancer diagnosis, subtyping, and treatment, where it complements routine histopathological evaluation by clarifying tumor phenotypes. In this work, we presen...
Humans Algorithms Phenotype Female Coloring Agents Actins Keratins Image Processing, Computer-Assisted Staining and Labeling Pancreatic Neoplasms Microscopy, Fluorescence Aged Biomarkers, Tumor Middle Aged Deep Learning
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Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.

Annals of the rheumatic diseases Oct 7, 2020
OBJECTIVE: We sought to determine histologic and gene expression features of clinical improvement in early diffuse cutaneous systemic sclerosis (dcSSc; scleroderma).
Antigens, CD34 Collagen Actins Clinical Trials as Topic Severity of Illness Index Fibroblasts Gene Expression Skin Forearm Scleroderma, Diffuse Humans Adult Machine Learning Male Middle Aged Female
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Robust blind spectral unmixing for fluorescence microscopy using unsupervised learning.

PloS one Dec 2, 2019
Due to the overlapping emission spectra of fluorophores, fluorescence microscopy images often have bleed-through problems, leading to a false positive detection. This problem is almost unavoidable when the samples are labeled with three or more fluor...
Fluorescence Cattle Microscopy, Confocal Photons Cell Nucleus Algorithms Unsupervised Machine Learning Actins Fluorescent Dyes Animals Endothelial Cells Microscopy, Fluorescence Pulmonary Artery Mitochondria
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Characterization of Nanoscale Organization of F-Actin in Morphologically Distinct Dendritic Spines Using Supervised Learning.

eNeuro Aug 1, 2019
The cytoarchitecture of a neuron is very important in defining morphology and ultrastructure. Although there is a wealth of information on the molecular components that make and regulate these ultrastructures, there is a dearth of understanding of ho...
Male In Vitro Techniques Image Processing, Computer-Assisted Rats, Sprague-Dawley Female Animals Dendritic Spines Supervised Machine Learning Microscopy Hippocampus Actins
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Convolutional neural network for cell classification using microscope images of intracellular actin networks.

PloS one Mar 13, 2019
Automated cell classification is an important yet a challenging computer vision task with significant benefits to biomedicine. In recent years, there have been several studies attempted to build an artificial intelligence-based cell classifier using ...
Actins Cytoplasm Cytoskeleton Microscopy, Fluorescence Image Processing, Computer-Assisted Breast Humans Cell Line Automation Neural Networks, Computer Models, Statistical Pattern Recognition, Automated Machine Learning MCF-7 Cells Reproducibility of Results Algorithms Breast Neoplasms Female Cell Line, Tumor
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Fluorescence microscopy image classification of 2D HeLa cells based on the CapsNet neural network.

Medical & biological engineering & computing Jan 28, 2019
The development of computer technology now allows the quick and efficient automatic fluorescence microscopy generation of a large number of images of proteins in specific subcellular compartments using fluorescence microscopy. Digital image processin...
HeLa Cells Actins Humans Neural Networks, Computer Image Processing, Computer-Assisted Support Vector Machine Microscopy, Fluorescence
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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging.

Nature communications Apr 27, 2018
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called ...
Microfilament Proteins Potoroidae Pseudopodia Vasodilator-Stimulated Phosphoprotein Animals Cell Adhesion Molecules Cell Line, Tumor Humans Actin Cytoskeleton Cell Movement Intravital Microscopy Machine Learning Cluster Analysis Actin-Related Protein 2-3 Complex Models, Biological Software Cell Line Phosphoproteins Indoles Actins
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Quantitative assessment of cancer cell morphology and motility using telecentric digital holographic microscopy and machine learning.

Cytometry. Part A : the journal of the International Society for Analytical Cytology Dec 28, 2017
The noninvasive, fast acquisition of quantitative phase maps using digital holographic microscopy (DHM) allows tracking of rapid cellular motility on transparent substrates. On two-dimensional surfaces in vitro, MDA-MB-231 cancer cells assume several...
Cell Nucleus Actins Cell Cycle Cell Adhesion Cell Line, Tumor Cell Movement Neoplasm Invasiveness Microscopy, Fluorescence Holography Humans Machine Learning Breast Neoplasms
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Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.

International journal of nanomedicine Dec 18, 2017
CD44 ligand-receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic ba...
Microscopy, Atomic Force Single Molecule Imaging Cell Survival Melanoma Actins Quantum Dots Animals Hyaluronan Receptors Kinetics Cell Line, Tumor Tubulin Dacarbazine Mice
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Simulation of a Free Boundary Cell Migration Model through Physics Informed Neural Networks.

Journal of the mechanical behavior of biomedical materials Jul 1, 2025
Understanding the complexities of single-cell migration is facilitated by computational modeling, which provides important insights into the physiological processes that underlie migration mechanisms. This study developed a computational model for on...
Cell Movement Models, Biological Actins Neural Networks, Computer Mechanical Phenomena Biomechanical Phenomena Actomyosin
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