AIMC Topic: Adult

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Effect of a Cognitive Behavioral Therapy-Based AI Chatbot on Depression and Loneliness in Chinese University Students: Randomized Controlled Trial With Financial Stress Moderation.

JMIR mHealth and uHealth
BACKGROUND: Mental health concerns are prevalent among university students, with financial stress further compounding these issues. While cognitive behavioral therapy (CBT) is effective for these conditions, its delivery through artificial intelligen...

Integrative analysis of transcriptome and metabolome profiles reveals immune-metabolic alterations in pulmonary sarcoidosis.

Metabolomics : Official journal of the Metabolomic Society
BACKGROUND: Pulmonary sarcoidosis, a disease of unknown etiology, is characterized by the presence of noncaseating granulomas in lung parenchyma. This present study combines metabolomic and transcriptomic data to determine the metabolic and different...

Identifying key brain pathology in bipolar and unipolar depression using a region-specific brain aging trajectories approach: Insights from the Taiwan Aging and Mental Illness Cohort.

Psychological medicine
BACKGROUND: Identifying key areas of brain dysfunction in mental illness is critical for developing precision diagnosis and treatment. This study aimed to develop region-specific brain aging trajectory prediction models using multimodal magnetic reso...

A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.

Lipids in health and disease
BACKGROUND: Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is...

Hip, knee, and ankle joint forces during exoskeletal-assisted walking: Comparison of approaches to simulate human-robot interactions.

PloS one
The overall goal of this study was to develop a computational framework to quantify hip, knee, and ankle joint forces during exoskeletal-assisted walking (EAW) in the ReWalk P6.0, an FDA-approved lower-extremity exoskeleton. The first objective was t...

Increased GM-WM in a prefrontal network and decreased GM in the insula and the precuneus are associated with reappraisal usage and reduced perceived stress: A data fusion approach.

Neuropsychologia
Emotion regulation plays a crucial role in mental health, and difficulties in regulating emotions can contribute to psychological disorders. While reappraisal and suppression are well-studied strategies, the joint contributions of gray matter (GM) an...

Neural correlates of metacognition in education: a machine learning approach.

Neuropsychologia
Metacognition, the ability to reflect and regulate one's cognitive processes, has been shown to play a role in various aspects of life, particularly in academic settings. While important steps have been made in uncovering the neural basis of metacogn...

Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome.

JCI insight
Inflammation plays important roles in the pathogenesis of vascular diseases. We here show the involvement of perivascular inflammation in aortic dilatation of Marfan syndrome (MFS). In the aorta of patients with MFS and Fbn1C1041G/+ mice, macrophages...

Inflammation and B cell activation define a plasma proteome signature predicting tuberculosis in people with HIV.

mBio
Improved biomarkers for predicting progression to active tuberculosis (TB) are urgently needed, especially in people with HIV, who are at elevated risk. We used high-throughput plasma proteomics and machine learning to identify signatures associated ...

Nasopharyngeal cancer adaptive radiotherapy with CBCT-derived synthetic CT: deep learning-based auto-segmentation precision and dose calculation consistency on a C-Arm linac.

Radiation oncology (London, England)
BACKGROUND: To evaluate the precision of automated segmentation facilitated by deep learning (DL) and dose calculation in adaptive radiotherapy (ART) for nasopharyngeal cancer (NPC), leveraging synthetic CT (sCT) images derived from cone-beam CT (CBC...