AIMC Topic: Animals
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Current and future applications of robotics in structural heart interventions.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Jul 7, 2025
Robotics entered the cardiovascular field in the late 1990s with a robot-assisted coronary artery bypass graft. Since then, the use of robots has become a common part of cardiovascular surgery in several types of interventions. The experience in tran...
Multi-task genomic prediction using gated residual variable selection neural networks.
BMC bioinformatics
Jul 7, 2025
BACKGROUND: The recent development of high-throughput sequencing techniques provide massive data that can be used in genome-wide prediction (GWP). Although GWP is effective on its own, the incorporation of traditional polygenic pedigree information i...
Nuclear morphometrics coupled with machine learning identifies dynamic states of senescence across age.
Nature communications
Jul 7, 2025
Cellular senescence is an irreversible state of cell cycle arrest with a complex role in tissue repair, aging, and disease. However, inconsistencies in identifying cellular senescence have led to varying conclusions about their functional significanc...
Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson's disease using diffusion imaging and tractography.
Journal of neural engineering
Jul 7, 2025
Parkinson's disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic (DA) neurons in the midbrain which trig...
Achyranthes Bidentata Radix mitigates neuronal apoptosis via regulation of JUN and CREB in the cAMP signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Jul 5, 2025
BACKGROUND: Although Achyranthes Bidentata Radix (ABR) demonstrates neuroprotective potential in NDDs, its anti-apoptotic mechanisms remain unclear.
Multimodal Optical Imaging Combined with Radiomic Analysis for Fibrotic Cardiac Tissue Investigation.
Analytical chemistry
Jul 5, 2025
Understanding the process of fibrotic scarring of the myocardium is critical for the diagnosis and risk stratification of life-threatening cardiac dysfunction. Complex changes in structure, composition, and conductivity occurring at different stages ...
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Jul 5, 2025
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.
Molecular medicine (Cambridge, Mass.)
Jul 5, 2025
BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme,...
A modular fluorescent camera unit for wound imaging.
Communications biology
Jul 5, 2025
Advanced imaging tools are revolutionizing the diagnosis, treatment, and monitoring of medical conditions, offering unprecedented insights into live cell behavior and biophysical markers. We introduce a modular, hand-held fluorescent microscope featu...
Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis.
Journal of nanobiotechnology
Jul 5, 2025
BACKGROUND: Osteoarthritis (OA), the most prevalent joint disorder, is characterized by a complex etiology and a lack of safe and effective therapeutic interventions. Emerging evidence suggests that immune cell dysregulation plays a pivotal role in t...
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