AIMC Topic: Anti-Inflammatory Agents, Non-Steroidal

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Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy Dec 28, 2016
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...
HT29 Cells Tumor Cells, Cultured Murraya Anti-Inflammatory Agents, Non-Steroidal Zebrafish Alkaloids Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Structure-Activity Relationship Humans Cytokines Animals Apoptosis Lipopolysaccharides Dose-Response Relationship, Drug Cell Survival Mice Nitric Oxide Cell Proliferation
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Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.

Pharmaceutical development and technology Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
Cell Survival Lipids Humans Cell Line, Tumor Drug Compounding Surface Properties Viscosity Lubricant Eye Drops Poloxamer Delayed-Action Preparations Drug Carriers Nanostructures Ibuprofen Anti-Inflammatory Agents, Non-Steroidal Drug Liberation Rheology Ophthalmic Solutions Drug Stability
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Automated evaluation of protein binding affinity of anti-inflammatory choline based ionic liquids.

Talanta Dec 10, 2015
In this work, an automated system for the study of the interaction of drugs with human serum albumin (HSA) was developed. The methodology was based on the quenching of the intrinsic fluorescence of HSA by binding of the drug to one of its binding sit...
Choline Ionic Liquids Automation Serum Albumin Protein Binding Anti-Inflammatory Agents, Non-Steroidal Humans
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Pharmacokinetic profiles of meloxicam in turtles (Trachemys scripta scripta) after single oral, intracoelomic and intramuscular administrations.

Journal of veterinary pharmacology and therapeutics Aug 12, 2015
Meloxicam is an anti-inflammatory and analgesic drug used to treat many pathological conditions in turtles. With the aim to fill the lack of data about its pharmacokinetic in this species, eighteen turtles (Trachemys scripta scripta) were divided in ...
Female Animals Anti-Inflammatory Agents, Non-Steroidal Meloxicam Turtles Thiazines Drug Administration Routes Area Under Curve Half-Life Thiazoles
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A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Aug 5, 2015
The acceleration of solid dosage form product development can be facilitated by the inclusion of excipients that exhibit poly-/multi-functionality with reduction of the time invested in multiple excipient optimisations. Because active pharmaceutical ...
Arginine Microscopy, Electron, Scanning Surface Properties Elasticity Powders Expert Systems Drug Compounding Mechanical Phenomena Excipients Compressive Strength Indomethacin Static Electricity Tensile Strength Statistics as Topic Tablets Algorithms Anti-Inflammatory Agents, Non-Steroidal Drug Liberation Computational Biology Porosity
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Pharmacokinetics of single and repeat doses of icatibant.

Clinical pharmacology in drug development Feb 2, 2015
PURPOSE: Icatibant is a bradykinin-2 receptor antagonist approved to treat acute hereditary angioedema attacks in adults. To-date, no thorough investigation of the clinical pharmacokinetic (PK) parameters of icatibant and its primary metabolites has ...
Bradykinin B2 Receptor Antagonists Drug Administration Schedule Metabolic Clearance Rate Bradykinin Adolescent Injections, Subcutaneous Anti-Inflammatory Agents, Non-Steroidal Healthy Volunteers Half-Life Area Under Curve Models, Biological Adult Male Middle Aged Humans Female Young Adult
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica Mar 1, 2017
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Half-Life Metabolic Clearance Rate Therapeutic Equivalency Sulfonamides Tablets Chromatography, High Pressure Liquid Cross-Over Studies Healthy Volunteers Pakistan Administration, Oral Anti-Inflammatory Agents, Non-Steroidal Area Under Curve Humans Models, Biological Young Adult Male
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