AIMC Topic: Biomarkers
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An Artificial Intelligence Olfactory-Based Diagnostic Model for Parkinson's Disease Using Volatile Organic Compounds from Ear Canal Secretions.
Analytical chemistry
May 28, 2025
Parkinson's Disease (PD), a frequently diagnosed neurodegenerative condition, poses a major global challenge. Early diagnosis and intervention are crucial for PD treatment. This study proposes a diagnostic model for PD that analyzes volatile organic ...
Eyes Are the Windows to the Soul: Reviewing the Possible Use of the Retina to Indicate Traumatic Brain Injury.
International journal of molecular sciences
May 28, 2025
Traumatic brain injury (TBI) induces complex molecular and cellular responses, often leading to vision deterioration and potential mortality. Current objective diagnostic methods are limited, necessitating the development of novel tools to assess dis...
MicroRNA signature predicts post operative atrial fibrillation after coronary artery bypass grafting.
Scientific reports
May 28, 2025
Early detection of atrial fibrillation (AFib) is crucial for altering its natural progression and complication profile. Traditional demographic and lifestyle factors often fail as predictors of AFib. This study investigated pre-operative, circulating...
Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.
Frontiers in immunology
May 28, 2025
BACKGROUND: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the p...
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
EBioMedicine
May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Immunogenic cell death biomarkers for sepsis diagnosis and mechanism via integrated bioinformatics.
Scientific reports
May 27, 2025
Immunogenic cell death (ICD) has been implicated in sepsis, a condition with high mortality, through mechanisms involving endoplasmic reticulum stress and other pathophysiological pathways. This study aimed to identify and validate ICD-related biomar...
MultiOmicsAgent: Guided Extreme Gradient-Boosted Decision Trees-Based Approaches for Biomarker-Candidate Discovery in Multiomics Data.
Journal of proteome research
May 25, 2025
MultiOmicsAgent (MOAgent) is an innovative, Python-based open-source tool for biomarker discovery, utilizing machine learning techniques, specifically extreme gradient-boosted decision trees, to process multiomics data. With its cross-platform compat...
Novel Technologies in Preterm Birth Prediction: Current Advances and Ethical Challenges.
Journal of mother and child
May 24, 2025
Preterm birth (PTB) remains a significant challenge in modern obstetric practice, posing considerable risks to maternal and neonatal health. Despite advancements in medical technology, the incidence of PTB remains high, and its prediction continues t...
The Gut Microbiota in Young Adults with High-Functioning Autism Spectrum Disorder and Its Performance as Diagnostic Biomarkers.
Nutrients
May 22, 2025
Diagnosing ASD in adults presents unique challenges, and there are currently no specific biomarkers for this condition. Most existing studies on the gut microbiota in ASD are conducted in children; however, the composition of the gut microbiota in c...
Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.
Frontiers in immunology
May 22, 2025
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.
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