AIMC Topic: Dose-Response Relationship, Drug

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Personalized oncology with artificial intelligence: The case of temozolomide.

Artificial intelligence in medicine Aug 12, 2019
PURPOSE: Using artificial intelligence techniques, we compute optimal personalized protocols for temozolomide administration in a population of patients with variability.
Humans Bayes Theorem Models, Biological Tumor Burden Maximum Tolerated Dose Temozolomide Artificial Intelligence Algorithms Computer Simulation Brain Neoplasms Dose-Response Relationship, Drug
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Evaluation of a sensor algorithm for motor state rating in Parkinson's disease.

Parkinsonism & related disorders Mar 26, 2019
INTRODUCTION: A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkin...
Dose-Response Relationship, Drug Aged, 80 and over Motor Activity Humans Parkinson Disease Male Female Accelerometry Middle Aged Aged Antiparkinson Agents Wearable Electronic Devices Levodopa Support Vector Machine
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Partially spatially coherent digital holographic microscopy and machine learning for quantitative analysis of human spermatozoa under oxidative stress condition.

Scientific reports Mar 5, 2019
Semen quality assessed by sperm count and sperm cell characteristics such as morphology and motility, is considered to be the main determinant of men's reproductive health. Therefore, sperm cell selection is vital in assisted reproductive technology ...
Semen Analysis Spermatozoa Microscopy Holography Oxidative Stress Humans Image Processing, Computer-Assisted Machine Learning Cell Movement Male Dose-Response Relationship, Drug Hydrogen Peroxide
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Relative Factors Analysis of Imatinib Trough Concentration in Chinese Patients with Gastrointestinal Stromal Tumor.

Chemotherapy Mar 5, 2019
AIMS: Imatinib plasma trough levels (IM Cmin) have been reported to have a considerable clinical impact in patients with gastrointestinal stromal tumors (GISTs). We therefore have investigated the factors affecting IM plasma concentration in Chinese ...
Aged Aged, 80 and over Adult Body Surface Area Male Middle Aged Humans Female Gastrectomy Asian People Sex Factors Gastrointestinal Stromal Tumors Imatinib Mesylate Antineoplastic Agents China Dose-Response Relationship, Drug Antigens, CD34 Body Weight
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Time-dependent AI-Modeling of the anticancer efficacy of synthesized gallic acid analogues.

Computational biology and chemistry Feb 16, 2019
BACKGROUND/AIM: Main objective of this study is mapping of the anticancer efficacy of synthesized gallic acid analogues using modeling and artificial intelligence (AI) over a large range of concentrations and exposure times to explore the underline m...
Cell Proliferation Support Vector Machine Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Structure-Activity Relationship Algorithms Antineoplastic Agents Time Factors Cell Line, Tumor Models, Molecular Molecular Structure Gallic Acid PC-3 Cells Humans Artificial Intelligence Machine Learning
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Deep Learning-Based Prediction of Drug-Induced Cardiotoxicity.

Journal of chemical information and modeling Feb 15, 2019
Blockade of the human ether-à-go-go-related gene (hERG) channel by small molecules induces the prolongation of the QT interval which leads to fatal cardiotoxicity and accounts for the withdrawal or severe restrictions on the use of many approved drug...
Antineoplastic Agents Deep Learning Computational Biology Dose-Response Relationship, Drug Cardiotoxicity Risk Assessment Ether-A-Go-Go Potassium Channels
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Potential EEG biomarkers of sedation doses in intensive care patients unveiled by using a machine learning approach.

Journal of neural engineering Jan 31, 2019
OBJECTIVE: Sedation of neurocritically ill patients is one of the most challenging situation in ICUs. Quantitative knowledge on the sedation effect on brain activity in that complex scenario could help to uncover new markers for sedation assessment. ...
Brain Injuries Dose-Response Relationship, Drug Hypnotics and Sedatives Infusions, Intravenous Electroencephalography Critical Care Midazolam Male Middle Aged Cohort Studies Intraoperative Neurophysiological Monitoring Propofol Humans Machine Learning Prospective Studies Female Adult
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Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Dose-Response Relationship, Drug Estrogen Antagonists Reactive Oxygen Species Free Radical Scavengers Plant Leaves Male Humans Oxidation-Reduction Oxidative Stress Female DNA Damage Drug Evaluation, Preclinical Estradiol Young Adult Olea Antioxidants Adult Blood Cells Plant Extracts Comet Assay Diethylstilbestrol
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Machine vision analysis on abnormal respiratory conditions of mice inhaling particles containing cadmium.

Ecotoxicology and environmental safety Dec 18, 2018
Inhalable environmental toxicants can induce pulmonary malfunction resulting abnormal respiratory conditions. The traditional methods currently available to detect the respiratory condition of animals rely on differential pressure transducers and sig...
Particle Size Air Pollutants Particulate Matter Cadmium Video Recording Respiration Inhalation Exposure Respiratory Function Tests Aerosols Mice, Inbred Strains Lung Mice Occupational Exposure Models, Theoretical Dose-Response Relationship, Drug Machine Learning Animals Male
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Hispaglabridin B, a constituent of liquorice identified by a bioinformatics and machine learning approach, relieves protein-energy wasting by inhibiting forkhead box O1.

British journal of pharmacology Dec 4, 2018
BACKGROUND AND PURPOSE: Liquorice is the root of Glycyrrhiza glabra, which is a popular food in Europe and China that has previously shown benefits for skeletal fatigue and nutrient metabolism. However, the mechanism and active ingredients remain lar...
Structure-Activity Relationship Plant Roots Models, Molecular Molecular Structure Benzopyrans Computational Biology Glycyrrhiza Plant Extracts Transcription, Genetic Mice, Inbred C57BL Muscular Atrophy Dose-Response Relationship, Drug Forkhead Box Protein O1 Muscle, Skeletal Machine Learning Animals Male Mice
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