AIMC Topic: Double-Blind Method

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Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland) Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
Humans Dose-Response Relationship, Drug Diet Dietary Supplements Influenza Vaccines Double-Blind Method Selenium Saliva Immunoglobulins Immunity, Cellular Influenza, Human Cytokines Immunoglobulin A Antibodies, Viral Cell Proliferation Body Mass Index Female T-Lymphocytes Male Middle Aged
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A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone.

Pain medicine (Malden, Mass.) Dec 14, 2015
OBJECTIVE: Evaluate the human abuse potential (HAP) of an experimental, microsphere-in-capsule formulation of extended-release oxycodone (oxycodone DETERx®) (herein "DETERx").
Opioid-Related Disorders Cross-Over Studies Young Adult Delayed-Action Preparations Adult Male Oxycodone Middle Aged Administration, Intranasal Humans Double-Blind Method Analgesics, Opioid Female
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Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

Pain medicine (Malden, Mass.) Dec 14, 2015
OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential ...
Double-Blind Method Analgesics, Opioid Opioid-Related Disorders Cross-Over Studies Powders Illicit Drugs Drug Administration Schedule Delayed-Action Preparations Administration, Intranasal Hydrocodone Humans Female Young Adult Adult Male Middle Aged
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Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial.

Nutrition (Burbank, Los Angeles County, Calif.) Dec 7, 2015
OBJECTIVE: The aim of the present study was to assess the effects of pomegranate juice on the level of oxidative stress in the blood of endurance-based athletes. Pomegranate juice is rich in polyphenols, conferring it a higher antioxidant capacity th...
Double-Blind Method Protein Carbonylation Fruit and Vegetable Juices Athletes Physical Endurance Stress, Physiological Oxidative Stress Antioxidants Malondialdehyde Polyphenols C-Reactive Protein Spain Lythraceae E-Selectin Sports Nutritional Physiological Phenomena Humans Biomarkers Adult Male Middle Aged
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Edoxaban vs warfarin in patients with nonvalvular atrial fibrillation in the US Food and Drug Administration approval population: An analysis from the Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) trial.

American heart journal Dec 1, 2015
BACKGROUND: Edoxaban is a specific anti-Xa inhibitor that, in comparison to warfarin, has been found to be noninferior for the prevention of stroke or systemic embolism (SSE) and to reduce bleeding significantly in patients with nonvalvular atrial fi...
Warfarin Stroke Myocardial Infarction Atrial Fibrillation United States Food and Drug Administration Thiazoles Humans Pyridines Factor Xa Female Thrombolytic Therapy Factor Xa Inhibitors Aged Anticoagulants Drug Approval Male Blood Coagulation United States Double-Blind Method Dose-Response Relationship, Drug
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A prospective, randomized, blinded-endpoint, controlled study - continuous epidural infusion versus programmed intermittent epidural bolus in labor analgesia.

Brazilian journal of anesthesiology (Elsevier) Nov 19, 2015
BACKGROUND: There is evidence that administration of a programmed intermittent epidural bolus (PIEB) compared to continuous epidural infusion (CEI) leads to greater analgesia efficacy and maternal satisfaction with decreased anesthetic interventions.
Analgesia, Patient-Controlled Cesarean Section Humans Patient Satisfaction Adult Prospective Studies Infusion Pumps Anesthetics, Local Pregnancy Analgesia, Epidural Double-Blind Method Female Endpoint Determination Analgesia, Obstetrical Infant, Newborn
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Comparison of emergence after deep extubation using desflurane or desflurane with remifentanil in patients undergoing general anesthesia: a randomized trial.

Journal of clinical anesthesia Nov 11, 2015
STUDY OBJECTIVE: To compare recovery times and respiratory complications during emergence after deep extubation using either desflurane alone or a lower concentration of desflurane with remifentanil.
Airway Extubation Anesthesia Recovery Period Anesthetics, Inhalation Desflurane Pulmonary Alveoli Respiration Disorders Remifentanil Anesthesia, General Double-Blind Method Isoflurane Anesthetics, Intravenous Piperidines Young Adult Adult Male Middle Aged Postoperative Complications Humans Prospective Studies Female
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Effects of combining robot-assisted therapy with neuromuscular electrical stimulation on motor impairment, motor and daily function, and quality of life in patients with chronic stroke: a double-blinded randomized controlled trial.

Journal of neuroengineering and rehabilitation Oct 31, 2015
BACKGROUND: Robot-assisted therapy (RT) is a widely used intervention approach to enhance motor recovery in patients after stroke, but its effects on functional improvement remained uncertain. Neuromuscular electrical stimulation (NMES) is one potent...
Humans Female Aged Adult Male Middle Aged Hand Quality of Life Combined Modality Therapy Recovery of Function Exercise Therapy Chronic Disease Electric Stimulation Therapy Robotics Stroke Rehabilitation Double-Blind Method Wrist Joint
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Lidocaine 5% Patch for Treatment of Acute Pain After Robotic Cardiac Surgery and Prevention of Persistent Incisional Pain: A Randomized, Placebo-Controlled, Double-Blind Trial.

Pain medicine (Malden, Mass.) Jul 14, 2015
OBJECTIVES: To test the hypotheses that lidocaine 5% patches decrease the severity of acute pain and incidence of persistent incisional pain after robotic cardiac valve surgery.
Analgesia, Patient-Controlled Patient Satisfaction Heart Valves Acute Pain Transdermal Patch Male Middle Aged Lidocaine Humans Anesthetics, Local Pain Measurement Female Robotics Disability Evaluation Aged Double-Blind Method Pain, Postoperative Analgesics, Opioid Cardiac Surgical Procedures
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Comparison of Coopdech®, CoPilot®, Intubrite®, and Macintosh laryngoscopes for tracheal intubation during pediatric cardiopulmonary resuscitation: a randomized, controlled crossover simulation trial.

European journal of pediatrics May 21, 2015
UNLABELLED: The aim of the study was to compare the intubation times and success rates of various laryngoscopes during resuscitation in pediatric emergency intubation with uninterrupted chest compression on a standardized pediatric manikin model. Thi...
Female Adult Allied Health Personnel Male Clinical Competence Time Factors Humans Simulation Training Intubation, Intratracheal Laryngoscopes Double-Blind Method Cross-Over Studies Cardiopulmonary Resuscitation Laryngoscopy Manikins
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