AIMC Topic: Drug Delivery Systems
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.
Current pharmaceutical biotechnology
Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Smart Micro/Nano-robotic Systems for Gene Delivery.
Current gene therapy
Jan 1, 2017
BACKGROUND: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing...
The Feasibility of a Completely Automated Total IV Anesthesia Drug Delivery System for Cardiac Surgery.
Anesthesia and analgesia
Oct 1, 2016
BACKGROUND: In this pilot study, we tested a novel automatic anesthesia system for closed-loop administration of IV anesthesia drugs for cardiac surgical procedures with cardiopulmonary bypass. This anesthesia drug delivery robot integrates all 3 com...
Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Aug 1, 2016
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogel...
A device for controlled jet injection of large volumes of liquid.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Aug 1, 2016
We present a needle-free jet injection device controllably actuated by a voice coil and capable of injecting up to 1.3 mL. This device is used to perform jet injections of ~900 μL into porcine tissue. This is the first time that delivery of such a la...
Evaluation of a novel portable micro-pump and infusion system for drug delivery.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Aug 1, 2016
In this paper the design, fabrication and experimental results of a novel portable fixed-displacement micro-pump for controlled dosing and timing is described. The new pump is developed especially for high efficiency, high accuracy, ease of use and v...
A Study of Applications of Machine Learning Based Classification Methods for Virtual Screening of Lead Molecules.
Combinatorial chemistry & high throughput screening
Jan 1, 2015
The ligand-based virtual screening of combinatorial libraries employs a number of statistical modeling and machine learning methods. A comprehensive analysis of the application of these methods for the diversity oriented virtual screening of biologic...
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