AIMC Topic: Endoplasmic Reticulum Stress
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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.
Free radical biology & medicine
May 23, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Hep G2 Cells
Cyclin-Dependent Kinase Inhibitor p21
Mice, Inbred C57BL
Liver
Mice
Fatty Liver
Disease Models, Animal
Gene Expression Regulation
Endoplasmic Reticulum Stress
Phenylenediamines
Early Growth Response Protein 1
Diet, High-Fat
Ferroptosis
Non-alcoholic Fatty Liver Disease
Animals
Male
Humans
Establishment of a prognostic model based on ER stress-related cell death genes and proposing a novel combination therapy in acute myeloid leukemia.
Journal of translational medicine
May 21, 2025
BACKGROUND: Acute myeloid leukemia (AML) is a highly heterogeneous malignancy, presenting significant challenges in accurately predicting patient prognosis. Dysregulation of endoplasmic reticulum (ER) stress and resistance to programmed cell death (P...
Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning.
Frontiers in endocrinology
Mar 18, 2025
BACKGROUND: Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become a growing public health problem worldwide. There is evidence that endoplasmic reticulum stress (ERS) is involved in the pathog...
Investigation and validation of genes associated with endoplasmic reticulum stress in diabetic retinopathy using various machine learning algorithms.
Experimental eye research
Mar 3, 2025
BACKGROUND: Diabetic retinopathy (DR) is a common complication of diabetes, with Endoplasmic reticulum stress (ERS) playing a key role in cellular adaptation, injury, or apoptosis, impacting disease pathology. This study aimed to identify early diagn...
Integrating cellular experiments, single-cell sequencing, and machine learning to identify endoplasmic reticulum stress biomarkers in idiopathic pulmonary fibrosis.
Annals of medicine
Sep 28, 2024
BACKGROUND: Idiopathic Pulmonary Fibrosis (IPF) presents a severe respiratory challenge with a poor prognosis due to the lack of reliable biomarkers. Recent evidence suggests that Endoplasmic Reticulum Stress (ERS) may be associated with IPF pathogen...
Identification of endoplasmic reticulum stress genes in human stroke based on bioinformatics and machine learning.
Neurobiology of disease
Jun 26, 2024
After ischemic stroke (IS), secondary injury is intimately linked to endoplasmic reticulum (ER) stress and body-brain crosstalk. Nonetheless, the underlying mechanism systemic immune disorder mediated ER stress in human IS remains unknown. In this st...
Utilizing Machine Learning to Identify Biomarkers of Endoplasmic Reticulum Stress and Analyze Immune Cell Infiltration in Parkinson's Disease.
Molecular neurobiology
Mar 23, 2024
The neurodegenerative disorder known as Parkinson's disease (PD) affects many people. The objective of this investigation was to examine the relationship between immune system infiltration, ATP-binding cassette transporter subfamily A member 7 (ABCA7...
Glycotherapy: A New Paradigm in Breast Cancer Research.
Biomolecules
Mar 23, 2022
Breast cancer is an ancient disease recognized first by the Egyptians as early as 1600 BC. The first cancer-causing gene in a chicken tumor virus was found in 1970. The United States signed the National Cancer Act in 1971, authorizing federal funding...
In vitro intestinal epithelium responses to titanium dioxide nanoparticles.
Food research international (Ottawa, Ont.)
Oct 12, 2018
Titanium dioxide (TiO) is enclosed in many consumer products including pharmaceuticals, cosmetics, and foods. TiO (E171) is daily ingested as mixed nano- and submicron-sized particles since it is approved as a white colorant in Europe in a wide varie...
KDELR3 and YOD1 proteins as critical endoplasmic reticulum stress mediators and potential therapeutic targets in diabetic foot ulcers: An integrated bioinformatics analysis.
International journal of biological macromolecules
Jun 1, 2025
BACKGROUND: Diabetic foot ulcers (DFU) represent one of the most severe complications of diabetes mellitus and are closely associated with persistent hyperglycemia. Endoplasmic reticulum stress response proteins play critical roles in the development...
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