Diabetic nephropathy (DN) is the main cause of end‑stage renal disease, with epithelial‑mesenchymal transition (EMT) serving a key role in its initiation and progression. Nevertheless, the precise mechanisms involved remain unidentified. The present ...
AIM: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are closely intertwined comorbidities that present significant clinical challenges due to the poorly understood pathophysiological mechanisms driving their coexistence. In this ...
Ferroptosis and lethal sepsis are interlinked, although this association remains largely unknown to clinical panels. Sepsis is characterized by dysfunction of the inflammatory microenvironment. Most septic biomarkers lack independent validation, and ...
BACKGROUND: Diabetic nephropathy (DN), affecting 30%-40% of diabetic patients, is the leading cause of end-stage renal disease worldwide. This study aims to identify diagnostic biomarkers and explore potential gene-metabolite interactions in DN patho...
Biochemical and biophysical research communications
Aug 30, 2025
BACKGROUND: Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease characterized by progressive dilation of the abdominal aorta, which poses a life-threatening risk upon rupture. Lactate, a key metabolic byproduct and immunomodulat...
BACKGROUND: Gluconeogenesis is a critical metabolic pathway for maintaining glucose homeostasis, and its dysregulation can lead to glycometabolic disorders. This study aimed to identify hub biomarkers of these disorders to provide a theoretical found...
There was increasing evidence that lipid metabolism disorders played a significant part in the maturation of Parkinson's disease (PD). The purpose of the article was to investigate a significance of lipid metabolism-related genes (LMRGs) in the matur...
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a prevalent condition that poses a major threat to public health. Endothelial cells play a critical role in COPD pathogenesis. Recent evidence suggests that the effective...
Journal of cellular and molecular medicine
Jul 1, 2025
BACKGROUND: The global increase in thyroid cancer prevalence, particularly among female populations, underscores critical gaps in our understanding of molecular pathogenesis and diagnostic capabilities. Our investigation addresses these knowledge def...
Lactate metabolism is implicated in myocardial infarction (MI), yet the underlying mechanisms are not fully understood. Identifying lactate metabolism-related genes (LMRGs) could uncover new diagnostic and therapeutic targets for MI. We conducted a b...
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