AIMC Topic: HIV Infections

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Classification and Design of HIV-1 Integrase Inhibitors Based on Machine Learning.

Computational and mathematical methods in medicine Apr 1, 2021
A key enzyme in human immunodeficiency virus type 1 (HIV-1) life cycle, integrase (IN) aids the integration of viral DNA into the host DNA, which has become an ideal target for the development of anti-HIV drugs. A total of 1785 potential HIV-1 IN inh...
Molecular Structure Bayes Theorem HIV-1 HIV Integrase Inhibitors Databases, Pharmaceutical Drug Design HIV Integrase HIV Infections Humans Computational Biology Machine Learning Decision Trees Structure-Activity Relationship
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Robot-Based Assessment of HIV-Related Motor and Cognitive Impairment for Neurorehabilitation.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Mar 3, 2021
There is a pressing need for strategies to slow or treat the progression of functional decline in people living with HIV. This paper explores a novel rehabilitation robotics approach to measuring cognitive and motor impairment in adults living with H...
Recovery of Function Robotics Stroke Humans Upper Extremity Stroke Rehabilitation Adult Neurological Rehabilitation Cross-Sectional Studies Cognitive Dysfunction HIV Infections
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Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.

Frontiers in immunology Feb 18, 2021
Predictive models are becoming more and more commonplace as tools for candidate antigen discovery to meet the challenges of enabling epitope mapping of cohorts with diverse HLA properties. Here we build on the concept of using two key parameters, div...
Genetic Variation Humans Host-Pathogen Interactions Genome, Viral Machine Learning Epitopes, T-Lymphocyte Viral Proteins Peptides Antigens, Viral HIV Infections Proteome CD8-Positive T-Lymphocytes HLA Antigens HIV
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Domain-Scan: Combinatorial Sero-Diagnosis of Infectious Diseases Using Machine Learning.

Frontiers in immunology Feb 10, 2021
The presence of pathogen-specific antibodies in an individual's blood-sample is used as an indication of previous exposure and infection to that specific pathogen (e.g., virus or bacterium). Measurement of the diagnostic antibodies is routinely achie...
Hepatitis C Antibodies HIV Core Protein p24 Genetic Vectors HIV Antibodies Humans Peptide Fragments AIDS Serodiagnosis Machine Learning Epitopes Serologic Tests Communicable Diseases Antigen-Antibody Reactions Amino Acid Sequence High-Throughput Nucleotide Sequencing DNA, Recombinant HIV Infections Oligonucleotides DNA Barcoding, Taxonomic HIV Envelope Protein gp160 Peptide Library Hepatitis C Base Sequence Hepatitis C Antigens Polymerase Chain Reaction
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Evolution of drug resistance in HIV protease.

BMC bioinformatics Dec 30, 2020
BACKGROUND: Drug resistance is a critical problem limiting effective antiviral therapy for HIV/AIDS. Computational techniques for predicting drug resistance profiles from genomic data can accelerate the appropriate choice of therapy. These techniques...
Machine Learning Phenotype HIV Infections Genotype Evolution, Molecular HIV-1 Humans Drug Resistance, Viral HIV Protease HIV Protease Inhibitors
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Training confounder-free deep learning models for medical applications.

Nature communications Nov 26, 2020
The presence of confounding effects (or biases) is one of the most critical challenges in using deep learning to advance discovery in medical imaging studies. Confounders affect the relationship between input data (e.g., brain MRIs) and output variab...
Magnetic Resonance Imaging Predictive Value of Tests Radiography Hand Sex Characteristics Adolescent HIV Infections Cohort Studies Child Age Factors Sex Factors Image Interpretation, Computer-Assisted Datasets as Topic Age Determination by Skeleton Brain Female Aged Aged, 80 and over Young Adult Adult Male Middle Aged Case-Control Studies Deep Learning Humans
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HIV-positive patients with oral Kaposi's sarcoma: An overall survival analysis of 31 patients.

Oral surgery, oral medicine, oral pathology and oral radiology Nov 20, 2020
OBJECTIVE: The aim of this study was to evaluate the influence of viral load and lymphocyte count on survival of patients who presented with human immunodeficiency virus (HIV)-associated oral Kaposi's sarcoma.
Brazil Humans HIV Infections Young Adult CD4 Lymphocyte Count Adult Survival Analysis Male Sarcoma, Kaposi Middle Aged
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Chest x-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: a prospective study of diagnostic accuracy for culture-confirmed disease.

The Lancet. Digital health Oct 19, 2020
BACKGROUND: Deep learning-based radiological image analysis could facilitate use of chest x-rays as triage tests for pulmonary tuberculosis in resource-limited settings. We sought to determine whether commercially available chest x-ray analysis softw...
Tuberculosis, Pulmonary Mycobacterium tuberculosis Sex Factors X-Rays Age Factors Triage Radiology Sputum Female Pakistan HIV Infections Humans Middle Aged Lung Deep Learning Young Adult Adult Sensitivity and Specificity Male Software Prospective Studies Image Processing, Computer-Assisted Body Mass Index
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Artificial Intelligence Applied to Gene Expression Testing (IVIGET) to Predict Trivalent Inactivated Influenza Vaccine Immunogenicity in HIV Infected Children.

Frontiers in immunology Oct 5, 2020
The number of patients affected by chronic diseases with special vaccination needs is burgeoning. In this scenario, predictive markers of immunogenicity, as well as signatures of immune responses are typically missing even though it would especially ...
Influenza Vaccines Influenza A Virus, H1N1 Subtype Immunogenicity, Vaccine Artificial Intelligence Vaccines, Inactivated Prognosis Hemagglutination Inhibition Tests Reproducibility of Results Child Gene Expression Profiling Computational Biology Transcriptome Vaccination HIV Infections Humans Coinfection Influenza, Human
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PeptiDesCalculator: Software for computation of peptide descriptors. Definition, implementation and case studies for 9 bioactivity endpoints.

Proteins Sep 17, 2020
We present a novel Java-based program denominated PeptiDesCalculator for computing peptide descriptors. These descriptors include: redefinitions of known protein parameters to suite the peptide domain, generalization schemes for the global descriptio...
Humans Neural Networks, Computer Software Anti-Bacterial Agents Neoplasms Protein Stability Candida albicans Peptides Peptide Mapping Antifungal Agents Antineoplastic Agents Listeria monocytogenes HIV Infections Pseudomonas aeruginosa Antiviral Agents Hepatitis C Support Vector Machine
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