AIMC Topic: Macrophages
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Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.
Environmental toxicology
May 26, 2015
Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide range of adverse health outcomes for which inflammation has also been hypothesized as a potentially ...
Estradiol
Inflammation
Signal Transduction
Benzhydryl Compounds
Cell Movement
Lipopolysaccharides
Cell Migration Assays, Macrophage
Humans
Phenols
Chemotaxis, Leukocyte
Macrophages
Tumor Necrosis Factor-alpha
Interleukin-1beta
Diethylhexyl Phthalate
Cells, Cultured
Cytokines
NF-kappa B
Female
Middle Aged
Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Aug 15, 2025
Atherosclerosis (AS) is a major contributor to cardiovascular disease. In traditional Chinese medicine, Tribulus terrestris L., or Baijili (BJL), has shown therapeutic effects on inflammation and cardiovascular issues. Our prior research indicated th...
The Critical Role of APOE+ Macrophages in the Immune Microenvironment and Prognosis of Lung Adenocarcinoma.
Journal of cellular and molecular medicine
Aug 1, 2025
The immunoregulatory functions and clinical implications of APOE+ macrophages within the tumour microenvironment of lung adenocarcinoma remain incompletely defined. In this study, single-cell transcriptome analysis revealed distinct subsets of APOE+ ...
Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.
Computational biology and chemistry
Aug 1, 2025
BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflamm...
Identification of biomarkers and immune infiltration associated with sexes in SSc: a bioinformatics and machine learning.
Rheumatology (Oxford, England)
Jun 1, 2025
OBJECTIVE: This study aimed to identify key candidate genes associated with the sexes of patients with SSc.
Integration of Bulk RNA and Single-Cell Analyses Reveal Distinct Expression Patterns of Anoikis-Related Genes and the Immunosuppressive Role of NQO1 Macrophages in Hepatocellular Carcinoma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 31, 2025
Anoikis resistance plays a crucial role in the proliferation, metastasis, and invasion of hepatocellular carcinoma (HCC). However, the key genes involved remain to be identified. This study aimed to investigate the prognostic value and impact of anoi...
Integrated machine learning survival framework develops a prognostic model based on macrophage-related genes and programmed cell death signatures in a multi-sample Kidney renal clear cell carcinoma.
Cell biology and toxicology
May 30, 2025
BACKGROUND: Macrophages are closely associated with the progression of Kidney renal clear cell carcinoma (KIRC) and can influence programmed cell death (PCD) of tumour cells. To identify prognostic biomarkers for KIRC, it is essential to investigate ...
Machine learning-based label-free macrophage phenotyping in immune-material interactions.
Journal of materials chemistry. B
May 21, 2025
The rapid advancement of implantable biomedical materials necessitates a comprehensive understanding of macrophage interactions to optimize implant immunocompatibility. Macrophages, key immune regulators, exhibit phenotypic plasticity by polarizing i...
Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy.
Clinical and experimental medicine
May 9, 2025
While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, th...
Identification of key genes and immune infiltration mechanisms in limb ischemia-reperfusion injury: a bioinformatics and experimental study.
Frontiers in immunology
Jan 1, 2025
AIM OF THE STUDY: To establish a cross-tissue bioinformatics model for identifying conserved key genes and immune infiltration mechanisms in ischemia-reperfusion injury (IRI) with experimental validation in limb IRI, including pharmacological targeti...
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