AIMC Topic: Mice
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Subsecond Analysis of Locomotor Activity in Parkinsonian Mice.
eNeuro
Aug 5, 2025
The degeneration of midbrain dopamine (DA) neurons disrupts the neural control of natural behavior, such as walking, posture, and gait in Parkinson's disease. While some aspects of motor symptoms can be managed by DA replacement therapies, others res...
Prediction of the hypothalamus-pituitary organoid formation using machine learning.
Cell reports methods
Aug 4, 2025
Multi-cellular organoids are self-assembly aggregates that mimic biological functions and developmental processes of many tissue types in vitro. They are widely employed for disease modeling and functional studies. Hypothalamus-pituitary organoids ca...
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis.
Nature communications
Aug 4, 2025
Current first-line treatments of paediatric ulcerative colitis (UC) maintain a 6-month remission in only half of the patients. Relapse prediction at diagnosis could enable earlier introduction of immunosuppressants. We collected intestinal biopsies f...
Detection of Unlabeled Polystyrene Micro- and Nanoplastics in Mammalian Tissue by Optical Photothermal Infrared Spectroscopy.
Analytical chemistry
Aug 1, 2025
In this study, we investigate the efficacy of optical photothermal infrared (O-PTIR) spectroscopy, also known as mid-infrared photothermal (MIP) microscopy, for label-free and nondestructive detection of micro- and nanoplastics (MNPs) down to diamete...
High-Resolution Ultrasound Data for AI-Based Segmentation in Mouse Brain Tumor.
Scientific data
Jul 30, 2025
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer, making effective treatments essential to improve patient survival. To advance the understanding of GBM and develop more effective therapies, preclinical studies commonly use m...
PuMA: PubMed gene/cell type-relation Atlas.
BMC bioinformatics
Jul 29, 2025
BACKGROUND: Rapid extraction and visualization of cell-specific gene expression is important for automatic cell type annotation, e.g. in single cell analysis. There is an emerging field in which tools such as curated databases or machine learning met...
Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor.
Neurochemical research
Jul 29, 2025
Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related...
Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC.
NPJ biofilms and microbiomes
Jul 28, 2025
The role of gut dysbiosis in shaping immunotherapy responses is well-recognized, yet its effect on the therapeutic efficacy of chemotherapy and immunotherapy combinations remains poorly understood. We analyzed gut microbiota in non-small cell lung ca...
Machine Learning-Enhanced Single-Particle Tracking for Rapid Screening of Tumor Immunomodulatory Drugs.
ACS nano
Jul 21, 2025
The tumor microenvironment plays a critical role in tumor progression and immune response, with the extracellular matrix (ECM) regulating immune cell infiltration. However, the interplay between ECM dynamics and tumor immunity remains poorly understo...
Efficient Compression of Mass Spectrometry Images via Contrastive Learning-Based Encoding.
Analytical chemistry
Jul 21, 2025
In this study, we introduce a novel encoding algorithm utilizing contrastive learning to address the substantial data size challenges inherent in mass spectrometry imaging. Our algorithm compresses MSI data into fixed-length vectors, significantly re...
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