BACKGROUND: Data on neoadjuvant treatment with trastuzumab biosimilars, particularly CT-P6, in combination with pertuzumab, are limited. This study evaluates the efficacy, tolerability, and immunogenicity of CT-P6 plus pertuzumab and chemotherapy, in...
Archives of gynecology and obstetrics
Jan 20, 2026
INTRODUCTION: We aimed to develop a machine learning model for first-trimester prediction of gestational diabetes mellitus (GDM) in twin pregnancies using a prospective international, multi-center cohort and identify useful predictive markers. METHOD...
Hernia : the journal of hernias and abdominal wall surgery
Jan 16, 2026
BACKGROUND: Incisional hernia (IH) is a significant complication that occurs after midline laparotomy and is associated with high morbidity and economic impacts. A fundamental goal of preventing IH is to determine which patients are considered low- o...
PURPOSE: Decision-making for orchiectomy following testicular torsion often relies on subjective clinical evaluations. This study investigates the efficacy of machine learning (ML) models in objectively predicting post-torsion testicular viability, a...
BACKGROUND/AIMS: To evaluate the performance of an artificial intelligence (AI) model for detecting and monitoring microbial keratitis (MK) using anterior segment optical coherence tomography (AS-OCT).
BACKGROUND: Hypertension remains a major global health challenge, significantly increasing cardiovascular and all-cause mortality risks. While exercise therapy is effective, conventional approaches face limitations in accessibility and personalizatio...
Journal of neurointerventional surgery
Jan 13, 2026
BACKGROUND: Automated machine learning (ML)-based large vessel occlusion (LVO) detection algorithms have been shown to improve in-hospital workflow metrics including door-to-groin time (DTG). The degree to which care team engagement and interaction a...
Six months of drug treatment is standard of care for drug-sensitive pulmonary tuberculosis (TB). Understanding the factors determining the length of treatment required for durable cure would allow individualization of treatment durations. We conducte...
INTRODUCTION: After curative treatment for colorectal cancer (CRC), there is a 15% risk of recurrence. Early detection of an asymptomatic recurrence may lead to curative treatment options. To date, follow-up strategies do not have optimal sensitivity...
BACKGROUND: Undiagnosed cognitive impairment poses a global challenge, prompting recent interest in ultra-brief screening questionnaires (comprising <2 to 3 items) to efficiently identify individuals needing further evaluation. However, evidence on u...
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