AIMC Topic: Proto-Oncogene Proteins c-akt
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Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.
International journal of molecular sciences
Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Epithelial Cells
Cell Survival
Protective Agents
Blotting, Western
Anti-Inflammatory Agents
Humans
Cell Migration Assays
Apoptosis
Cytokines
Ginsenosides
Lipopolysaccharides
Reproducibility of Results
Phosphatidylinositol 3-Kinases
Nephritis
Cell Line
Enzyme-Linked Immunosorbent Assay
Proto-Oncogene Proteins c-akt
Reactive Oxygen Species
Analysis of Variance
Kidney Tubules
Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.
International journal of clinical and experimental pathology
Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Disulfides
Allyl Compounds
Protein Kinase Inhibitors
Cholangiocarcinoma
Phosphatidylinositol 3-Kinase
Phosphoinositide-3 Kinase Inhibitors
Dose-Response Relationship, Drug
Antineoplastic Agents, Phytogenic
Phosphorylation
Proto-Oncogene Proteins c-akt
Bile Duct Neoplasms
Cell Proliferation
Signal Transduction
Humans
Cell Movement
Neoplasm Invasiveness
Cell Line, Tumor
Disentangling multidimensional spatio-temporal data into their common and aberrant responses.
PloS one
Apr 22, 2015
With the advent of high-throughput measurement techniques, scientists and engineers are starting to grapple with massive data sets and encountering challenges with how to organize, process and extract information into meaningful structures. Multidime...
Computer-aided unveiling molecular mechanisms of Xylocarpus granatum against colorectal cancer: therapeutic intervention targeting P13K-AKT signaling pathway.
Computers in biology and medicine
Jul 1, 2025
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality globally, with increasing incidence rates, particularly in early-onset cases. Despite advances in treatment, many developing countries face affordability and safety ...
Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
Jan 1, 2025
BACKGROUND: Postoperative delirium (POD) poses significant clinical challenges regarding its diagnosis and treatment. Identifying biomarkers that can predict and diagnose POD is crucial for improving patient outcomes.
[Experimental study of APB-DOCK8 transgenic tomato vaccine for caries prevention].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2023
PURPOSE: To observe the anti-caries effect of transgenic tomato anti-caries vaccine after immunization with SD rats by gavage and to explore its immunity mechanism initially.
CODEX, a neural network approach to explore signaling dynamics landscapes.
Molecular systems biology
Apr 1, 2021
Current studies of cell signaling dynamics that use live cell fluorescent biosensors routinely yield thousands of single-cell, heterogeneous, multi-dimensional trajectories. Typically, the extraction of relevant information from time series data reli...
Algorithms
Animals
Signal Transduction
Cell Line
Fluorescent Dyes
Humans
Neural Networks, Computer
Machine Learning
Radiation, Ionizing
Extracellular Signal-Regulated MAP Kinases
Tumor Suppressor Protein p53
Proto-Oncogene Proteins c-akt
Databases as Topic
Transforming Growth Factor beta
Movement
Light
Dose-Response Relationship, Radiation
Intercellular Signaling Peptides and Proteins
Drosophila
[Effect of glutaredoxin on oxidative stress of umbilical vein endothelial cell exposed to Porphyromonas gingivalis lipo- polysaccharide].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Dec 1, 2015
OBJECTIVE: This study measures the glutaredoxin (Grx) gene and protein expression in umbilical vein endothelial cells upon exposure to Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS). The involvement of the Akt-signaling pathway is ...
[Effects of exogenous recombinant human basic fibroblast growth factor on the healing of muscles in rats after deep tissue injury of pressure ulcers].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
Dec 1, 2015
OBJECTIVE: To investigate the effect of exogenous recombinant human basic fibroblast growth factor (rhbFGF) on the healing of muscles in rats after deep tissue injury of pressure ulcers.
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