AIMC Topic: Proto-Oncogene Proteins c-akt

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Integrating machine learning and high throughput screening for the discovery of allosteric AKT1 inhibitors.

Journal of biomolecular structure & dynamics Dec 14, 2023
Evidence from clinical and experimental investigations reveals the role of AKT in oral cancer, which has led to the development of therapeutic and pharmacological medications for inhibiting AKT protein. Despite prodigious effort, researchers are sear...
Humans Machine Learning Molecular Dynamics Simulation High-Throughput Screening Assays Molecular Docking Simulation Quantitative Structure-Activity Relationship Drug Discovery Protein Kinase Inhibitors Protein Binding Allosteric Regulation Proto-Oncogene Proteins c-akt
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The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo.

Journal of ethnopharmacology Oct 28, 2023
ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Artemisia argyi has been used medicinally and eaten for more than 2000 years in China. It is widely reported in treating inflammatory diseases such as eczema, dermatitis, arthritis, a...
Animals Artemisia RNA, Messenger Molecular Docking Simulation Plant Extracts Water Inflammation Mice Lipopolysaccharides NF-kappa B Anti-Inflammatory Agents Proto-Oncogene Proteins c-akt Matrix Metalloproteinase 9
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The antidiabetic drug pioglitazone ameliorates betel-nut-induced carcinogenesis in mice by restoring normal lipid metabolism, reducing oxidative stress, and inducing apoptosis.

Journal of cancer research and therapeutics Apr 27, 2023
CONTEXT: Oral administration (2 mg mL-1) of aqueous extract of betel nut (AEBN) for 24 weeks induced oncogenic alterations in the liver of female Swiss Albino mice concomitant with aberrant lipid metabolism, overactivation of Akt/mTOR signaling, and ...
Proto-Oncogene Proteins c-akt Lipid Metabolism Pioglitazone Animals Areca Female Hypoglycemic Agents Nuts Oxidative Stress Apoptosis Mice TOR Serine-Threonine Kinases Lipids Carcinogenesis
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Exploring the Study of miR-1301 Inhibiting the Proliferation and Migration of Squamous Cell Carcinoma YD-38 Cells through PI3K/AKT Pathway under Deep Learning Medical Images.

Computational intelligence and neuroscience Feb 10, 2022
With the rapid development and application of deep learning medical image recognition, natural language processing, and other fields, at the same time, deep learning has become the most popular research direction in the field of image processing and ...
MicroRNAs Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt Deep Learning Cell Proliferation Signal Transduction Cell Movement Humans Carcinoma, Squamous Cell
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Deep learning-driven scaffold hopping in the discovery of Akt kinase inhibitors.

Chemical communications (Cambridge, England) Oct 12, 2021
Scaffold hopping has been widely used in drug discovery and is a topic of high interest. Here a deep conditional transformer neural network, SyntaLinker, was applied for the scaffold hopping of a phase III clinical Akt inhibitor, AZD5363. A number of...
Humans Drug Discovery Pyrroles Protein Kinase Inhibitors Deep Learning Pyrimidines Molecular Structure Proto-Oncogene Proteins c-akt
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A risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models.

Journal of advanced research Nov 11, 2020
INTRODUCTION: Ovarian cancer (OC) is one of the most frequent gynecologic cancers among women, and high-accuracy risk prediction techniques are essential to effectively select the best intervention strategies and clinical management for OC patients a...
Phosphatidylinositol 3-Kinases Proto-Oncogene Proteins c-akt TOR Serine-Threonine Kinases Carcinoma, Ovarian Epithelial Gene Expression Regulation, Neoplastic Models, Theoretical Ovarian Neoplasms Gene Expression Algorithms Prognosis Humans Female Machine Learning Survival Rate Risk Assessment
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Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature.

eLife May 14, 2020
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based ...
Machine Learning Phenotype Animals Gene Expression Profiling Transcriptome Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-akt Bone Marrow Cells Gene Expression Regulation Single-Cell Analysis RNA-Seq Genotype Cluster Analysis Regulatory-Associated Protein of mTOR T-Box Domain Proteins Killer Cells, Natural T-bet Transcription Factor Forkhead Box Protein O1 Mechanistic Target of Rapamycin Complex 2 Rapamycin-Insensitive Companion of mTOR Protein
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Recognition of early and late stages of bladder cancer using metabolites and machine learning.

Metabolomics : Official journal of the Metabolomic Society Jun 20, 2019
INTRODUCTION: Bladder cancer (BCa) is one of the most common and aggressive cancers. It is the sixth most frequently occurring cancer in men and its rate of occurrence increases with age. The current method of BCa diagnosis includes a cystoscopy and ...
Proto-Oncogene Proteins c-akt Glycine Galactose ErbB Receptors Software Biomarkers, Tumor Insulin ROC Curve Area Under Curve Neoplasm Staging Amino Acids Urinary Bladder Neoplasms Metabolic Networks and Pathways Humans Machine Learning
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Leptin Stimulates Prolactin mRNA Expression in the Goldfish Pituitary through a Combination of the PI3K/Akt/mTOR, MKK/pMAPK and MEK/ERK Signalling Pathways.

International journal of molecular sciences Dec 20, 2017
Leptin actions at the pituitary level have been extensively investigated in mammalian species, but remain insufficiently characterized in lower vertebrates, especially in teleost fish. Prolactin (PRL) is a pituitary hormone of central importance to o...
Cells, Cultured Pituitary Gland Animals MAP Kinase Signaling System Receptors, Leptin Proto-Oncogene Proteins c-akt Prolactin TOR Serine-Threonine Kinases Fish Proteins RNA, Messenger Leptin Goldfish Phosphatidylinositol 3-Kinases
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Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas Dec 11, 2017
Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LP...
Humans Cytokines Reproducibility of Results Ginsenosides Enzyme-Linked Immunosorbent Assay Nephritis Cell Line Reactive Oxygen Species Epithelial Cells Apoptosis Lipopolysaccharides Cell Survival Analysis of Variance Phosphatidylinositol 3-Kinases Protective Agents Kidney Tubules Blotting, Western Proto-Oncogene Proteins c-akt Cell Migration Assays Anti-Inflammatory Agents
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