AIMC Topic: Reactive Oxygen Species
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Cytocompatible manganese dioxide-based hydrogel nanoreactors for MRI imaging.
Biomaterials advances
Dec 3, 2021
The application of nanoparticles in magnetic resonance imaging (MRI) has been greatly increasing, due to their advantageous properties such as nanoscale dimension and tuneability. In this context, manganese (Mn)-based nanoparticles have been greatly ...
Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals.
Toxicology letters
Nov 5, 2021
Although many neurotoxicity prediction studies of food additives have been developed, they are applicable in a qualitative way. We aimed to develop a novel prediction score that is described quantitatively and precisely. We examined cell viability, r...
Biodegradable Small-Scale Swimmers for Biomedical Applications.
Advanced materials (Deerfield Beach, Fla.)
Sep 3, 2021
Most forms of biomatter are ephemeral, which means they transform or deteriorate after a certain time. From this perspective, implantable healthcare devices designed for temporary treatments should exhibit the ability to degrade and either blend in w...
Predicting Proteolysis in Complex Proteomes Using Deep Learning.
International journal of molecular sciences
Mar 17, 2021
Both protease- and reactive oxygen species (ROS)-mediated proteolysis are thought to be key effectors of tissue remodeling. We have previously shown that comparison of amino acid composition can predict the differential susceptibilities of proteins t...
Towards a new model and classification of mood disorders based on risk resilience, neuro-affective toxicity, staging, and phenome features using the nomothetic network psychiatry approach.
Metabolic brain disease
Jan 7, 2021
Current diagnoses of mood disorders are not cross validated. The aim of the current paper is to explain how machine learning techniques can be used to a) construct a model which ensembles risk/resilience (R/R), adverse outcome pathways (AOPs), stagin...
Chestnut shells (Italian cultivar "Marrone di Roccadaspide" PGI): Antioxidant activity and chemical investigation with in depth LC-HRMS/MS rationalization of tannins.
Food research international (Ottawa, Ont.)
Nov 20, 2019
In Italy a particularly valuable chestnut is "Marrone di Roccadaspide", a protected geographical indication (PGI) product, deriving from a Castanea sativa cultivar, typical of Salerno province in Campania region. As chestnut industrial processes yiel...
Machine Learning to Quantitate Neutrophil NETosis.
Scientific reports
Nov 15, 2019
We introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate...
Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.
PloS one
Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Plasmonic MoO nanoparticles incorporated in Prussian blue frameworks exhibit highly efficient dual photothermal/photodynamic therapy.
Journal of materials chemistry. B
Feb 21, 2019
Development of near infrared (NIR) light-responsive nanomaterials for high performance multimodal phototherapy within a single nanoplatform is still challenging in technology and biomedicine. Herein, a new phototherapeutic nanoagent based on FDA-appr...
Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Humans
Female
Young Adult
Adult
Male
Oxidative Stress
Reactive Oxygen Species
Plant Leaves
Olea
Estrogen Antagonists
Oxidation-Reduction
Estradiol
Blood Cells
Free Radical Scavengers
DNA Damage
Antioxidants
Comet Assay
Drug Evaluation, Preclinical
Plant Extracts
Diethylstilbestrol
Dose-Response Relationship, Drug
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