AIMC Topic: Transcriptome
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The impact of aging on achilles tendon ossification in mice.
BMC musculoskeletal disorders
May 28, 2025
BACKGROUND: Heterotopic ossification is a frequent complication of soft tissue injuries, particularly in tendons. Although ossification in tendon tissue has been reported in a range of aging and disease models, the underlying biomarkers and mechanism...
Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.
Frontiers in immunology
May 27, 2025
BACKGROUND: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK c...
Mechanistic exploration of hexokinase 2 and metabolism in diabetic cardiomyopathy.
Molecular medicine reports
May 26, 2025
The pathogenesis of diabetic cardiomyopathy (DCM) remains incompletely understood. The present study employed weighted gene co‑expression network analysis to analyze the DCM transcriptome dataset from the Gene Expression Omnibus (GEO) database to ide...
Sex-related differences and associated transcriptional signatures in the brain ventricular system and cerebrospinal fluid development in full-term neonates.
Biology of sex differences
May 25, 2025
BACKGROUND: The cerebrospinal fluid (CSF) is known to serve as a unique environment for neurodevelopment, with specific proteins secreted by epithelial cells of the choroid plexus (CP) playing crucial roles in cortical development and cell differenti...
Image guided construction of a common coordinate framework for spatial transcriptome data.
Scientific reports
May 24, 2025
Spatial transcriptomics is a powerful technology for high-resolution mapping of gene expression in tissue samples, enabling a molecular level understanding of tissue architecture. The acquisition entails dissecting and profiling micron-thick tissue s...
Machine Learning-Based Analysis of Differentially Expressed Genes in the Muscle Transcriptome Between Beef Cattle and Dairy Cattle.
International journal of molecular sciences
May 23, 2025
Muscle is a crucial component of cattle, playing a vital role in determining the final quality of beef. This study aimed to identify candidate genes associated with muscle growth and lipid metabolism in beef and dairy cattle by utilizing the public d...
Identification of m5C RNA modification-related gene signature for predicting prognosis and immune microenvironment-related characteristics of heart failure.
Hereditas
May 22, 2025
BACKGROUND: Methylation of RNA is involved in many pathophysiological processes. The roles of N6-methyladenosine (m6A) and N7-methylguanosine (m7G) in heart failure (HF) have been established. However, the impact of 5-methylcytosine (m5C) on HF and i...
Transcriptome combined with Mendelian randomization to identify key genes related to polyamine metabolism in childhood obesity and elucidate their molecular regulatory mechanisms.
Scientific reports
May 22, 2025
Currently, research has found a close correlation between childhood obesity (CO) and elevated levels of polyamines in the bloodstream. Thus, the identification of key genes associated with polyamines metabolism in CO could offer fresh insights for cl...
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.
Frontiers in immunology
May 22, 2025
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...
Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.
Frontiers in immunology
May 22, 2025
INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the complex tumor microenvironment...
Female
Tumor Escape
Colorectal Neoplasms
Cell Line, Tumor
CD8-Positive T-Lymphocytes
Tumor Microenvironment
Male
Single-Cell Analysis
Amino Acids
Gene Expression Regulation, Neoplastic
Gene Expression Profiling
Humans
Programmed Cell Death 1 Receptor
Lymphocytes, Tumor-Infiltrating
Transcriptome
Prognosis
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