Primary myelofibrosis (PMF) is a heterogeneous bone marrow disorder, and substantial evidence indicates the involvement of inflammatory mediators in its progression. However, a diagnostic model based on inflammation-related genes has not yet been est...
Systemic lupus erythematosus (SLE), characterized by immune dysregulation, urgently requires improved diagnostic tools and mechanistic insights. The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcripto...
Cholangiocarcinoma is a very deadly epithelial cell cancer with poor clinical outcome. Cellular senescence plays a vital role in the oncogenesis and the aggressiveness of cholangiocarcinoma. Integrative machine learning procedure including 10 methods...
Cancer is a complex disease characterized by uncontrolled cell growth, which can invade surrounding tissues and spread to distant organs. Most of the conventional methods of diagnosis fails to identify the primary organ when cancer spreads to other o...
This study examines the function of chromatin-remodeling genes (CRGs) in nasopharyngeal carcinoma (NPC), with an emphasis on their potential as prognostic and diagnostic biomarkers. We examined gene expression information collected from multiple data...
Gastric cancer (GC) presents striking survival disparities: 85-100% for early-stage versus only 5-20% for advanced disease. Glucose metabolic reprogramming (GMS)-a cancer hallmark linked to the Warburg effect-fuels tumor progression and immune evasio...
Recent advances in spatial transcriptomics (ST) have significantly enhanced our understanding of tissue structure and intercellular interactions. However, existing methods for spatial domain identification and cell type deconvolution still face chall...
Breast cancer (BC) is the most prevalent malignancy among women, and the steadily increasing disease burden has garnered considerable global attention. Post-translational modifications (PTMs) are critical in the initiation and progression of BC. This...
Acute Myeloid Leukemia (AML) is a genetically and clinically heterogeneous disease that can develop at any age. While AML incidence increases with age and distinct genetic alterations are observed in younger versus older patients, current classificat...
The rapid development of spatial transcriptomics (ST) has made it possible to effectively integrate gene expression and spatial information of cells and accurately identify spatial domains. A large number of deep learning (DL)-based methods have been...
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