AIMC Topic: Transcriptome

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Deep learning enables genetic analysis of the human thoracic aorta.

Nature genetics Nov 26, 2021
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic aorta in 4.6 million cardiac magnetic resonance i...
Humans Female Aged Adult Male Middle Aged Transcriptome Deep Learning Quantitative Trait Loci Genome-Wide Association Study Aortic Aneurysm Image Processing, Computer-Assisted Biological Variation, Population Magnetic Resonance Imaging Aorta, Thoracic
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Genes and regulatory mechanisms associated with experimentally-induced bovine respiratory disease identified using supervised machine learning methodology.

Scientific reports Nov 25, 2021
Bovine respiratory disease (BRD) is a multifactorial disease involving complex host immune interactions shaped by pathogenic agents and environmental factors. Advancements in RNA sequencing and associated analytical methods are improving our understa...
Supervised Machine Learning Host-Pathogen Interactions Bovine Respiratory Disease Complex Lung RNA-Seq Animals Gene Expression Profiling Gene Regulatory Networks Transcriptome Computational Biology Cattle Databases, Genetic
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Are we there yet? A machine learning architecture to predict organotropic metastases.

BMC medical genomics Nov 24, 2021
BACKGROUND & AIMS: Cancer metastasis into distant organs is an evolutionarily selective process. A better understanding of the driving forces endowing proliferative plasticity of tumor seeds in distant soils is required to develop and adapt better tr...
Transcriptome Machine Learning Databases, Factual Neoplasms Gene Expression Profiling Humans
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Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.

Cells Nov 23, 2021
Stem/progenitor cell transplantation is a potential novel therapeutic strategy to induce angiogenesis in ischemic tissue, which can prevent major amputation in patients with advanced peripheral artery disease (PAD). Thus, clinicians can use cell ther...
Genome-Wide Association Study Peripheral Arterial Disease Humans Whole Genome Sequencing Artificial Intelligence Cell- and Tissue-Based Therapy Precision Medicine Risk Factors Transcriptome
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Identification of Alzheimer associated differentially expressed gene through microarray data and transfer learning-based image analysis.

Neuroscience letters Nov 19, 2021
Major factors contribute to mental stress and enhance the progression of late-onset Alzheimer's disease (AD). The factors that lead to neurodegeneration, such as tau protein hyperphosphorylation and increased amyloid-beta production, can be mimicked ...
Alzheimer Disease Hippocampus Microarray Analysis Humans Neural Networks, Computer Animals Gene Expression Profiling Transcriptome Image Processing, Computer-Assisted Rats
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Manifold learning analysis suggests strategies to align single-cell multimodal data of neuronal electrophysiology and transcriptomics.

Communications biology Nov 19, 2021
Recent single-cell multimodal data reveal multi-scale characteristics of single cells, such as transcriptomics, morphology, and electrophysiology. However, integrating and analyzing such multimodal data to deeper understand functional genomics and ge...
Brain Animals Gene Expression Profiling Transcriptome Machine Learning Electrophysiological Phenomena Single-Cell Analysis Mice Neurons Electrophysiology
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Supervised learning based on tumor imaging and biopsy transcriptomics predicts response of hepatocellular carcinoma to transarterial chemoembolization.

Cell reports. Medicine Nov 16, 2021
Although transarterial chemoembolization (TACE) is the most widely used treatment for intermediate-stage, unresectable hepatocellular carcinoma (HCC), it is only effective in a subset of patients. In this study, we combine clinical, radiological, and...
Supervised Machine Learning Chemoembolization, Therapeutic Tumor Hypoxia Hepatic Artery Liver Neoplasms Adult Carcinoma, Hepatocellular Male Treatment Outcome Middle Aged Biopsy Transcriptome Humans Female Aged Aged, 80 and over
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The viral expression and immune status in human cancers and insights into novel biomarkers of immunotherapy.

BMC cancer Nov 5, 2021
BACKGROUND: Viral infections are prevalent in human cancers and they have great diagnostic and theranostic values in clinical practice. Recently, their potential of shaping the tumor immune microenvironment (TIME) has been related to the immunotherap...
Humans Machine Learning Stomach Neoplasms Papillomaviridae Oncogenic Viruses High-Throughput Nucleotide Sequencing Genome, Viral Tumor Virus Infections Kaplan-Meier Estimate Tumor Microenvironment Head and Neck Neoplasms RNA-Seq Biomarkers, Tumor Herpesvirus 4, Human Support Vector Machine Immunotherapy Neoplasms Mutation DNA, Viral Papillomavirus Infections Transcriptome Leukocytes Epstein-Barr Virus Infections Squamous Cell Carcinoma of Head and Neck Genetic Variation
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Construction and external validation of a 5-gene random forest model to diagnose non-obstructive azoospermia based on the single-cell RNA sequencing of testicular tissue.

Aging Nov 4, 2021
Non-obstructive azoospermia (NOA) is among the most severe factors for male infertility, but our understandings of the latent biological mechanisms remain insufficient. The single-cell RNA sequencing (scRNA-seq) data of 432 testicular cells isolated ...
Humans Machine Learning Single-Cell Analysis Protein Interaction Maps RNA-Seq Adult Azoospermia Male Transcriptome Diagnosis, Computer-Assisted
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Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram.

Nature methods Oct 28, 2021
Charting an organs' biological atlas requires us to spatially resolve the entire single-cell transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and single-nucleus RNA-seq (sc/snRNA-seq) can profile cells comprehe...
Single-Cell Analysis Gene Expression Regulation Software Male Regulatory Sequences, Nucleic Acid Brain RNA-Seq Gene Expression Profiling Chromatin Mice Female Transcriptome Mice, Inbred C57BL Animals Deep Learning
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