AIMC Topic: Biomarkers

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Breath profiles in paediatric allergic asthma by proton transfer reaction mass spectrometry.

BMJ open respiratory research Jun 27, 2025
INTRODUCTION: Enhancing paediatric asthma diagnosis is crucial. Molecular analysis of exhaled breath is a rapidly evolving field aimed at harnessing established and innovative technologies for clinical applications. This study evaluates the feasibili...
Female Asthma Male Case-Control Studies Humans Biomarkers Exhalation Protons Feasibility Studies Gas Chromatography-Mass Spectrometry Volatile Organic Compounds Breath Tests Adolescent Child, Preschool Child Mass Spectrometry
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Development of a Cohesive Predictive Model for Substance Use Disorder Rehabilitation Using Passive Digital Biomarkers, Psychological Assessments, and Automated Facial Emotion Recognition: Protocol for a Prospective Cohort Study.

JMIR research protocols Jun 27, 2025
BACKGROUND: Substance use disorder (SUD) involves excessive substance consumption and persistent reward-seeking behaviors, leading to serious physical, cognitive, and social consequences. This disorder is a global health crisis tied to increased mort...
Facial Recognition Humans Male Machine Learning Middle Aged Prospective Studies Emotions Biomarkers Substance-Related Disorders Young Adult Adult
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γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.

Military Medical Research Jun 27, 2025
γ neuromodulation has emerged as a promising strategy for addressing neurological and psychiatric disorders, particularly in regulating executive and cognitive functions. This review explores the latest neuromodulation techniques, focusing on the cri...
Humans Mental Disorders Biomarkers Nervous System Diseases Gamma Rhythm
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Machine learning for the prediction of spontaneous preterm birth using early second and third trimester maternal blood gene expression: A cautionary tale.

PloS one Jun 27, 2025
Spontaneous preterm birth (sPTB) remains a significant global health challenge and a leading cause of neonatal mortality and morbidity. Despite advancements in neonatal care, the prediction of sPTB remains elusive, in part due to complex etiologies a...
Humans Machine Learning Biomarkers Cohort Studies ROC Curve Pregnancy Trimester, Second Pregnancy Trimester, Third Pregnancy Female Premature Birth Adult
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Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis.

Renal failure Jun 25, 2025
BACKGROUND: The exact mechanism of graft dysfunction has not been fully clarified. We aimed to explore the causal effects of serum metabolites on graft dysfunction and the mediating role of inflammatory proteins.
Male Single-Cell Analysis Mendelian Randomization Analysis Graft Rejection Machine Learning Kidney Transplantation Biomarkers Humans Female
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Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and survival in patients with systemic sclerosis.

RMD open Jun 25, 2025
INTRODUCTION: Systemic sclerosis (SSc) is a complex inflammatory vasculopathy with diverse symptoms and variable disease progression. Despite its known impact on body composition (BC), clinical decision-making has yet to incorporate these biomarkers....
Aged Adult Male Middle Aged Severity of Illness Index Biomarkers Body Composition Prognosis Humans Scleroderma, Systemic Tomography, X-Ray Computed Prospective Studies Female
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Regional free-water diffusion is more strongly related to neuroinflammation than neurodegeneration.

Journal of neurology Jun 25, 2025
INTRODUCTION: Recent research has suggested that neuroinflammation may be important in the pathogenesis of neurodegenerative diseases. Free-water diffusion (FWD) has been proposed as a non-invasive neuroimaging-based biomarker for neuroinflammation.
Diffusion Magnetic Resonance Imaging Neuroinflammatory Diseases Neurodegenerative Diseases Glial Fibrillary Acidic Protein Neurofilament Proteins Humans Biomarkers Female Aged Aged, 80 and over Male Middle Aged Cognitive Dysfunction
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Comprehensive analysis and experimental validation of BST1 as a novel diagnostic biomarker for pediatric sepsis using multiple machine learning algorithms.

European journal of pediatrics Jun 25, 2025
Bone marrow stromal cell antigen-1 (BST1) expression is elevated in a variety of human diseases, but its relationship with pediatric sepsis is unclear. This study aimed to investigate the expression of BST1 in pediatric sepsis patients and its value ...
Child, Preschool ADP-ribosyl Cyclase Child Humans Machine Learning Male Antigens, CD ROC Curve Algorithms Infant GPI-Linked Proteins Enzyme-Linked Immunosorbent Assay Biomarkers Sepsis Receptors, Cell Surface Female Adolescent Isoantigens
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Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.

Cardiovascular diabetology Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Epigenesis, Genetic Inflammation DNA Methylation Cell-Free Nucleic Acids Non-ST Elevated Myocardial Infarction Predictive Value of Tests ST Elevation Myocardial Infarction Coronary Artery Disease Male Middle Aged Humans Risk Assessment Machine Learning Severity of Illness Index Biomarkers Inflammation Mediators Prognosis Female 5-Methylcytosine Reproducibility of Results Aged
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WISP2/CCN5 revealed as a potential diagnostic biomarker for endometriosis based on machine learning and single-cell transcriptomic analysis.

Functional & integrative genomics Jun 19, 2025
OBJECTIVE: Endometriosis is a prevalent gynecological disease characterized by the ectopic growth of functional endometrial tissue outside the uterine cavity, affecting millions of women worldwide. Currently, the definitive diagnosis relies on invasi...
Wnt Signaling Pathway Transcriptome Humans Repressor Proteins Single-Cell Analysis CCN Intercellular Signaling Proteins Endometrium Machine Learning Endometriosis Biomarkers Female
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