AIMC Topic: Cell Line, Tumor
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Assessing the impact of generative AI on medicinal chemistry.
Nature biotechnology
Feb 1, 2020
Ensembled machine learning framework for drug sensitivity prediction.
IET systems biology
Feb 1, 2020
Drug sensitivity prediction is one of the critical tasks involved in drug designing and discovery. Recently several online databases and consortiums have contributed to providing open access to pharmacogenomic data. These databases have helped in dev...
A Deep Learning Framework for Predicting Response to Therapy in Cancer.
Cell reports
Dec 10, 2019
A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001 cancer cell lines, we trained deep neural networks for prediction of drug response and asse...
[Inhibiting effect and mechanism of Lactobacillus E6-1 on oral cancer cell line Cal-27].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2019
PURPOSE: To study the effect of Lactobacillus E6-1 on proliferation and apoptosis of human oral cancer cell line Cal-27 in vitro.
Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson's disease.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To examine the role of KSOP1009 (a modified formulation of Suhexiang Wan essential oil) in an animal model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection.
Rumex dentatus could be a potent alternative to treatment of microbial infections and of breast cancer.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Dec 1, 2019
OBJECTIVE: To investigate the phytochemicals and in vitro antioxidant, antimicrobial and cytotoxic potential of Rumex dentatus (R. dentatus) leaf extracts.
In vitro cytotoxic, antioxidant, antibacterial and antifungal activity of Saussurea heteromalla indigenous to Pakistan.
Pakistan journal of pharmaceutical sciences
Nov 1, 2019
Medicinal plants are proven to reveal vast promising potential providing novel drug candidates to combat health-related problems. The aim of current study is to discover new drug compounds with anti-anticancer, antioxidant, antibacterial and antifung...
Effects of Jiazhu decoction in combination with cyclophosphamide on breast cancer in mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
Oct 1, 2019
OBJECTIVE: To investigate the therapeutic effects of Jiazhu decoction (JZD) in combination with cyclophosphamide (CTX) on the growth of breast cancer in mice and to explore the possible molecular mechanisms of action.
DriverML: a machine learning algorithm for identifying driver genes in cancer sequencing studies.
Nucleic acids research
May 7, 2019
Although rapid progress has been made in computational approaches for prioritizing cancer driver genes, research is far from achieving the ultimate goal of discovering a complete catalog of genes truly associated with cancer. Driver gene lists predic...
A platform for artificial intelligence based identification of the extravasation potential of cancer cells into the brain metastatic niche.
Lab on a chip
Mar 27, 2019
Brain metastases are the most lethal complication of advanced cancer; therefore, it is critical to identify when a tumor has the potential to metastasize to the brain. There are currently no interventions that shed light on the potential of primary t...
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