AIMC Topic: Down-Regulation

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Microarray expression profiling and gene ontology analysis of long non-coding RNAs in spontaneously hypertensive rats and their potential roles in the pathogenesis of hypertension.

Molecular medicine reports Nov 11, 2015
Long non-coding RNAs (lncRNAs) have been demonstrated to be significant in numerous biological processes. Hypertension is a form of cardiovascular disease with at least one billion cases worldwide. The present study sought to compare the differential...
Reproducibility of Results Animals Gene Expression Profiling Real-Time Polymerase Chain Reaction Hypertension Oligonucleotide Array Sequence Analysis Rats, Inbred SHR Rats, Inbred WKY RNA, Long Noncoding Gene Expression Regulation Down-Regulation Gene Ontology
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Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.

Environmental toxicology Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
Platinum Proto-Oncogene Proteins c-bcl-2 Down-Regulation Up-Regulation Nanotubes Acetylcysteine Caspase 9 G1 Phase Cell Cycle Checkpoints Caspase 3 Particle Size Real-Time Polymerase Chain Reaction MCF-7 Cells Gold RNA, Messenger Membrane Potential, Mitochondrial Apoptosis Humans Reactive Oxygen Species Female Breast Neoplasms
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SGNNMD: signed graph neural network for predicting deregulation types of miRNA-disease associations.

Briefings in bioinformatics Jan 17, 2022
MiRNAs are a class of small non-coding RNA molecules that play an important role in many biological processes, and determining miRNA-disease associations can benefit drug development and clinical diagnosis. Although great efforts have been made to de...
Neural Networks, Computer Algorithms Computational Biology MicroRNAs Down-Regulation
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Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.

Medicine Aug 21, 2020
Dermatomyositis is a common connective tissue disease. The occurrence and development of dermatomyositis is a result of multiple factors, but its exact pathogenesis has not been fully elucidated. Here, we used biological information method to explore...
Computational Biology Signal Transduction Dermatomyositis Down-Regulation Up-Regulation Humans Incidence Protein Interaction Maps Protein Binding Microarray Analysis Molecular Sequence Annotation Gene Ontology Double-Stranded RNA Binding Motif Interferon Type I
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Enrichment of Up-regulated and Down-regulated Gene Clusters Using Gene Ontology, miRNAs and lncRNAs in Colorectal Cancer.

Combinatorial chemistry & high throughput screening Jan 1, 2019
AIM AND OBJECTIVE: It is interesting to find the gene signatures of cancer stages based on the omics data. The aim of study was to evaluate and to enrich the array data using gene ontology and ncRNA databases in colorectal cancer.
Gene Expression Profiling Humans Multigene Family Gene Regulatory Networks High-Throughput Screening Assays Colorectal Neoplasms Databases, Genetic Down-Regulation MicroRNAs Up-Regulation Gene Ontology RNA, Long Noncoding
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Modulation of aldosterone levels by aldosterone synthase promoter polymorphism and association with eGFR decline in patients with chronic kidney disease.

Discovery medicine Dec 1, 2018
To determine whether -344T/C CYP11B2 promoter polymorphism affects serum aldosterone levels and whether this polymorphism is an indicator of eGFR decline in patients with chronic kidney disease. -344 C/T CYP11B2 gene polymorphism analysis was perform...
Renal Insufficiency, Chronic Glomerular Filtration Rate Follow-Up Studies Aldosterone Male Cerebrovascular Disorders Humans Cardiovascular Diseases Down-Regulation Female Middle Aged Cytochrome P-450 CYP11B2 Aged Disease Progression Promoter Regions, Genetic Adult Polymorphism, Single Nucleotide
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[Downregulation of PTTG1 expression inhibits the proliferation and invasiveness and promotes the apoptosis of human prostate cancer LNCaP-AI cells].

Zhonghua nan ke xue = National journal of andrology Jul 1, 2017
OBJECTIVE: To investigate the effects of down-regulation of PTTG1 expression on the proliferation, invasiveness and apoptosis of androgen-independent human prostate cancer LNCaP-AI cells and their sensitivity to androgen antagonists.
Apoptosis Neoplasm Invasiveness Prostatic Neoplasms Androgen Antagonists RNA, Small Interfering Male Time Factors Humans Cell Line, Tumor Cell Proliferation Transfection Securin Down-Regulation
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[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2016
To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon cancer.
 Methods: Crude extract was obtained from JPJD by water extract method. The effect of JPJD crude extract on colon cancer ce...
Humans Colorectal Neoplasms Animals Gene Expression Profiling Cell Line, Tumor Up-Regulation Cathepsin B Cathepsins Hypoxia-Inducible Factor 1, alpha Subunit Integrin alpha Chains Receptors, Urokinase Plasminogen Activator Sphingomyelin Phosphodiesterase STAT3 Transcription Factor Vascular Endothelial Growth Factor A Neovascularization, Pathologic Signal Transduction Tumor Suppressor Protein p53 Drugs, Chinese Herbal Down-Regulation Blotting, Western TOR Serine-Threonine Kinases
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Continuous Hemodiafiltration with an AN69ST Hemofilter (AN69ST-CHDF) as FGF-23-Lowering Therapy.

Clinical laboratory Dec 1, 2016
BACKGROUND: Recent studies have shown that fibroblast growth factor-23 (FGF-23) is elevated not only in chronic kidney disease (CKD), but also in acute illnesses such as acute kidney injury, septic shock, and acute heart failure. FGF-23 would be not ...
Surface Properties Acrylonitrile Membranes, Artificial Hemodiafiltration Equipment Design Fibroblast Growth Factor-23 Fibroblast Growth Factors Acrylic Resins Down-Regulation Protein Binding Treatment Outcome Female Adsorption Aged Acute Disease Humans Male Biomarkers Middle Aged Time Factors
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[Study of FN1 and ZNF438 gene expression negatively regulated by androgen receptor in androgen-independent LNCaP cells].

Zhonghua yi xue za zhi Dec 19, 2015
OBJECTIVE: To verify whether FN1 and ZNF438 are the androgen receptor(AR) target genes in LNCaP-AI cells and investigate the effects of AR exerts on FN1 and ZNF438 gene expression.
Gene Expression Blotting, Western Prostatic Neoplasms Fibronectins Down-Regulation Male Cell Line, Tumor RNA, Messenger Gene Expression Regulation, Neoplastic Humans Receptors, Androgen Oligonucleotide Array Sequence Analysis Repressor Proteins Androgens Dihydrotestosterone
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