AIMC Topic: Drug Combinations

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A novel aspartic protease from Rhizomucor miehei expressed in Pichia pastoris and its application on meat tenderization and preparation of turtle peptides.

Food chemistry Oct 23, 2017
A novel aspartic protease gene (RmproA) was cloned from the thermophilic fungus Rhizomucor miehei CAU432 and expressed in Pichia pastoris. The RmproA was successfully expressed in P. pastoris as an active extracellular protease. High protease activit...
Red Meat Hydrogen-Ion Concentration Animals Pichia Fermentation Aspartic Acid Proteases Fungal Proteins Peptides Papain Cloning, Molecular Swine Sodium, Dietary Rhizomucor Enzyme Stability Recombinant Proteins Substrate Specificity Drug Combinations Turtles
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The Safety and Efficacy of Adjuvant Hemostatic Agents During Laparoscopic Nephron-Sparing Surgery: Comparison of Tachosil and Floseal Versus No Hemostatic Agents.

Urology journal Jan 23, 2017
PURPOSE: To compare the effectiveness of TachoSil and Floseal during laparoscopic nephron-sparing surgery (LNSS), and to evaluate postoperative complications, especially hemorrhage and urinary leakage.
Laparoscopy Fibrinogen Kidney Neoplasms Nephrectomy Hemostatics Gelatin Sponge, Absorbable Male Humans Nephrons Retrospective Studies Middle Aged Organ Sparing Treatments Female Postoperative Complications Thrombin Treatment Outcome Drug Combinations
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Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.

Journal of clinical anesthesia Dec 22, 2016
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays function...
Fentanyl Osteoarthritis Analgesia, Patient-Controlled Arthroplasty, Replacement, Knee Pain Management Patient Satisfaction Nausea Analgesia, Epidural Prospective Studies Female Double-Blind Method Aged Humans Pain, Postoperative Male Drug Combinations Bupivacaine Middle Aged Amides Ropivacaine Treatment Outcome Postoperative Care Analgesics, Opioid Anesthetics, Local Pain Measurement
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Validated Chromatographic Methods for the Analysis of Two Binary Mixtures Containing Pyridoxine Hydrochloride.

Journal of AOAC International Dec 16, 2016
Accurate and precise TLC-densitometric and HPLC-diode-array detector (DAD) methods have been developed and validated to resolve two binary mixtures containing pyridoxine hydrochloride (PYH) with either cyclizine hydrochloride (CYH) or meclizine hydro...
Densitometry Cyclizine Meclizine Pyridoxine Drug Combinations Data Accuracy Chromatography, Reverse-Phase Chromatography, Thin Layer
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A randomised, phase III trial of once-daily fluticasone furoate/vilanterol 100/25 μg versus once-daily vilanterol 25 μg to evaluate the contribution on lung function of fluticasone furoate in the combination in patients with COPD.

Respiratory medicine Dec 2, 2016
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
Kaplan-Meier Estimate Administration, Inhalation Humans Androstadienes Female Adrenergic beta-2 Receptor Agonists Aged Benzyl Alcohols Quality of Life Chlorobenzenes Adult Drug Combinations Pulmonary Disease, Chronic Obstructive Double-Blind Method Male Forced Expiratory Volume Middle Aged Drug Administration Schedule Glucocorticoids
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Antimicrobial activity of ceftazidime-avibactam and comparator agents when tested against bacterial isolates causing infection in cancer patients (2013-2014).

Diagnostic microbiology and infectious disease Nov 29, 2016
We evaluated the antimicrobial susceptibility of 623 Gram-negative organisms causing infection in patients with cancer in 52 United States hospitals (2013-2014) as part of the International Network for Optimal Resistance Monitoring (INFORM) program. ...
Enterobacter cloacae Amikacin Azabicyclo Compounds Ceftazidime Thienamycins Escherichia coli beta-Lactamases Pseudomonas aeruginosa Meropenem Colistin Humans Anti-Bacterial Agents Neoplasms Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Klebsiella pneumoniae Drug Combinations
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Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form.

Journal of AOAC International Nov 15, 2016
Two specific, sensitive, and precise stability-indicating chromatographic methods were developed, optimized, and validated for the determination of Azintamide (AZ) in the presence of its degradation product. The first method was TLC combined with the...
Pancreatin Linear Models Pyridazines Cellulase Drug Combinations Chromatography, Thin Layer Tablets Densitometry Chromatography, High Pressure Liquid Hydrolysis Data Accuracy
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RenalGuard system in high-risk patients for contrast-induced acute kidney injury.

American heart journal Dec 17, 2015
BACKGROUND: High urine flow rate (UFR) has been suggested as a target for effective prevention of contrast-induced acute kidney injury (CI-AKI). The RenalGuard therapy (saline infusion plus furosemide controlled by the RenalGuard system) facilitates ...
Risk Factors Aged Drug Delivery Systems Male Glomerular Filtration Rate Sodium Chloride Drug Combinations Diuretics Follow-Up Studies Humans Isotonic Solutions Contrast Media Prospective Studies Angiography Equipment Design Acute Kidney Injury Urodynamics Coronary Artery Disease Female Furosemide Creatinine
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Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.

Clinical pharmacology in drug development Dec 4, 2015
PURPOSE: The purpose of this study was to investigate potential systemic pharmacokinetic interactions between intranasal fluticasone furoate (FF) and levocabastine (LEVO) when delivered simultaneously via a metered atomizing spray pump.
Middle Aged Glucocorticoids Drug Combinations Biological Availability Cross-Over Studies Piperidines Humans Female Young Adult Adult Male Androstadienes Administration, Intranasal Histamine H1 Antagonists, Non-Sedating
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Bioequivalence of fixed-dose combinations of dapagliflozin and metformin with single-component tablets in healthy subjects and the effect of food on bioavailability.

Clinical pharmacology in drug development Oct 20, 2015
The pharmacokinetics (PK) of dapagliflozin and metformin administered as fixed-dose combination (FDC) tablets (2.5 mg dapagliflozin/850 mg metformin or 5 mg dapagliflozin/1000 mg metformin) or as separate tablets in healthy subjects were evaluated in...
Fasting Food-Drug Interactions Hypoglycemic Agents Drug Combinations Area Under Curve Glucosides Tablets Biological Availability Cross-Over Studies Benzhydryl Compounds Metformin Therapeutic Equivalency Young Adult Adult Male Middle Aged Adolescent Humans Female
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