AIMC Topic: Humans

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Free Energy Projective Simulation (FEPS): Active inference with interpretability.

PloS one
In the last decade, the free energy principle (FEP) and active inference (AIF) have achieved many successes connecting conceptual models of learning and cognition to mathematical models of perception and action. This effort is driven by a multidiscip...

Data-driven identification of key predictors of uncontrolled hypertension: A cross-sectional study.

PloS one
Uncontrolled hypertension (HTN) increases the risk of adverse health events. This study aimed to identify key predictors of uncontrolled HTN in 1,308 Mexican adults with a prior diagnosis of HTN who were undergoing pharmacological treatment. We utili...

Breast cancer classification based on the integration of diagnostic algorithms for calcifications and masses using a mixture of experts.

PloS one
PURPOSE: To investigate the effectiveness of an integrated deep-learning (DL) algorithm, the Mixture of Radiological Findings Specific Experts (MoRFSE), in breast cancer classification by imitating the diagnostic decision-making process of radiologis...

The public's perceptions and attitudes of male nursing postgraduate professional identity on Chinese social media: Qualitative study based on machine learning.

PloS one
BACKGROUND: Professional identity plays a critical role in the career development of male postgraduate nursing students, particularly in contexts where gender imbalance and social stereotypes persist.

Residual disease in NPM1-mutated acute myeloid leukemia.

Clinica chimica acta; international journal of clinical chemistry
Acute myeloid leukemia (AML) represents a genetically heterogeneous malignancy, with mutations in the nucleophosmin-1 (NPM1) gene identified as the most prevalent and clinically significant molecular biomarkers. These mutations play a crucial pivotal...

From disinfectant to neurodegeneration: Integrating machine learning and mendelian randomization reveals triclosan as a novel environmental risk factor for Alzheimer's disease.

Environmental pollution (Barking, Essex : 1987)
This study systematically investigated the association between triclosan (TCS) exposure and Alzheimer's disease (AD) risk via integrated bioinformatics approaches. TCS-AD-related genes were identified using bioinformatics tools and public databases, ...

FAM46B inhibits CS-induced oxidative stress and ferroptosis in bronchial epithelial cells via KLHL24.

International immunopharmacology
BACKGROUND: Chronic obstructive pulmonary disease (COPD), mainly caused by cigarette smoke (CS), is a global health concern. Ferroptosis is recognized as a key driver of COPD progression, yet its underlying mechanisms are unclear. This study aimed to...

3,6'-Disinapoyl sucrose modulates GALE-mediated metabolic reprogramming to alleviate asthmatic airway inflammation.

International immunopharmacology
BACKGROUND: Asthma is a heterogeneous disease characterized by chronic airway inflammation and metabolic dysregulation. Recent studies highlight the role of glycolysis and oxidative phosphorylation (OXPHOS) imbalance in asthma pathogenesis, yet the u...

KPNA2 expression as a biomarker for immunosuppressive microenvironment predicting response to TKI and immunotherapy in metastatic renal cell carcinoma.

European journal of pharmacology
BACKGROUND: Immunotherapy (IO) combined with tyrosine kinase inhibitors (TKI) are now first-line therapy for advanced renal cell carcinoma (RCC), though reliable predictive biomarkers remain elusive. Recent evidence demonstrates that karyopherin α2 s...

Cognitive prediction using regional connectivities and network biomarkers in Alzheimer's disease.

Neuroscience
Achieving a deep understanding of brain mechanisms requires multi-scale perspectives to capture the architecture of complex networks. In this study, we focused on patients with cognitive impairment and constructed individual brain networks from neuro...