AIMC Topic: Humans

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To see or not to see the vet: A vignette-based study of decision-making by UK dog owners regarding seeking veterinary care for commonly presenting conditions.

PloS one
Barriers to accessing veterinary-care for dog-owners are diverse and dynamic, and widely accepted as major canine welfare threats because of potential non-, under- or delayed treatment. Owner knowledge and perceptions are recognised as key influences...

Machine learning and network pharmacology identify keloid biomarkers (AMPH, TNFRSF9) and therapeutic targets (IL6, HAS2) for aloe-derived quercetin.

PloS one
OBJECTIVE: This study aimed to identify diagnostic biomarkers for keloid and explore potential therapeutic agents from traditional Chinese medicine (TCM) by integrating network pharmacology approaches. Specifically, we sought to uncover key molecular...

Alzheimer's disease prediction via an explainable CNN using genetic algorithm and SHAP values.

PloS one
Convolutional neural networks (CNNs) are widely recognized for their high precision in image classification. Nevertheless, the lack of transparency in these black-box models raises concerns in sensitive domains such as healthcare, where understanding...

Radiomics profiling combined with clinical risk factors for preoperative Lymphatic Metastasis prediction in Colorectal cancer: A multicenter study.

PloS one
PURPOSE: Accurate preoperative assessment of regional lymphatic metastases (LNM) is essential for effective surgical selection of patients with colorectal cancer (CRC). This study aimed to develop a machine learning (ML) model that integrates radiomi...

SyMetrics: an integrated machine learning model for evaluating the pathogenicity of synonymous variants in the human genome.

NAR genomics and bioinformatics
Synonymous single nucleotide variants (sSNVs), traditionally seen as neutral, are now recognized for their biological impact. To assess their relevance, we developed SyMetrics, a framework that integrates predictors of splicing, RNA stability, evolut...

Skin disease diagnostics through federated transfer learning on heterogeneous data.

Scientific reports
Skin diseases frequently cause mental and physical distress and are major global health concern. Because early detection is crucial to successful treatment, accurate diagnosis is challenge for dermatologists as well. Diagnostic accuracy could be sign...

Pediatric diabetes prediction using machine learning.

Scientific reports
Diabetes is a chronic condition that affects a substantial portion of the global population and is linked to elevated mortality rates and a range of severe health complications. Despite its clinical importance, progress in diabetes research is often ...

Prompting and Fine-Tuning Large Language Models for Parkinson Disease Diagnosis: Comparative Evaluation Study Using the PPMI Structured Dataset.

JMIR medical informatics
BACKGROUND: Parkinson disease (PD) presents diagnostic challenges due to its heterogeneous motor and nonmotor manifestations. Traditional machine learning (ML) approaches have been evaluated on structured clinical variables. However, the diagnostic u...

AI-Driven Objective Structured Clinical Examination Generation in Digital Health Education: Comparative Analysis of Three GPT-4o Configurations.

JMIR medical education
BACKGROUND: Objective Structured Clinical Examinations (OSCEs) are used as an evaluation method in medical education, but require significant pedagogical expertise and investment, especially in emerging fields like digital health. Large language mode...

Mild Cognitive Impairment Detection System Based on Unstructured Spontaneous Speech: Longitudinal Dual-Modal Framework.

JMIR medical informatics
BACKGROUND: In recent years, the incidence of cognitive diseases has also risen with the significant increase in population aging. Among these diseases, Alzheimer disease constitutes a substantial proportion, placing a high-cost burden on health care...