Sepsis, marked by hyperinflammation and subsequent immunosuppression, lacks effective phase-specific therapies. Although anisodamine hydrobromide (Ani HBr) reduced 28-day mortality in our prior trial, its mechanisms remained unclear. Here, we integra...
Parkinson's disease (PD) is a progressive neurological disorder that impairs movement control, leading to symptoms such as tremors, stiffness, and bradykinesia. Early and accurate PD detection is essential for effective management and improving patie...
We conducted a multicenter retrospective analysis of 408 patients diagnosed with onychomycosis who attended three tertiary care Spanish hospitals. The study was conducted to assess the clinical characteristics and outcomes of onychomycosis patients u...
Minimally invasive liver surgery (MILS) offers significant benefits but faces limited adoption due to its steep learning curve. This study explores the potential of artificial intelligence (AI) in assisting the performance of major MILS by providing ...
Atrial fibrillation (AF) increases the risk of adverse cardiovascular events, yet the underlying biological mechanisms remain unclear. We evaluate a panel of 12 circulating biomarkers representing diverse pathophysiological pathways in 3817 AF patien...
BACKGROUND: Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited resp...
BACKGROUND: Depression is a mental health condition that affects millions of people worldwide. Although common, it remains difficult to diagnose due to its heterogeneous symptomatology. Mental health questionnaires are currently the most used assessm...
BACKGROUND: There is growing interest in applying generative artificial intelligence (GenAI) to respond to electronic patient portal messages, particularly in primary care where message volumes are highest. However, evaluations of GenAI as an inbox c...
BACKGROUND: In the German medical billing system, surgical departments encode their procedures in OPS-codes. These OPS-codes have major impact on DRG grouping and thus mainly determine each case´s revenue. In our study, we investigate the ability of ...
Myocardial infarction (MI) remains one of the greatest contributors to mortality, and patients admitted to the intensive care unit (ICU) with myocardial infarction are at higher risk of death. In this study, we use two retrospective cohorts extracted...
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