AIMC Topic: Mice, Inbred C57BL

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Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity Dec 14, 2021
Existing treatments for intracerebral hemorrhage (ICH) are unable to satisfactorily prevent development of secondary brain injury after ICH and multiple pathological mechanisms are involved in the development of the injury. In this study, we aimed to...
Cerebral Hemorrhage Interleukin-12 Collagenases Inflammasomes Sphingolipids Male Mice Proteome Brain Injuries Mice, Inbred C57BL Humans Biomarkers Prognosis Animals
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Discovery of Pyrazolo[3,4-]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Journal of medicinal chemistry Nov 25, 2021
Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease (IBD) therapy. A scaffold-based molecular design workflow was established and...
Molecular Structure Mice, Inbred ICR Anti-Inflammatory Agents Protein Kinase Inhibitors Pyridazines Dextran Sulfate Colitis Discoidin Domain Receptor 1 Pyrazolones Humans Drug Discovery Animals Drug Design Deep Learning Mice Mice, Inbred C57BL Drug Screening Assays, Antitumor
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Open-source deep learning-based automatic segmentation of mouse Schlemm's canal in optical coherence tomography images.

Experimental eye research Nov 16, 2021
The purpose of this study was to develop an automatic deep learning-based approach and corresponding free, open-source software to perform segmentation of the Schlemm's canal (SC) lumen in optical coherence tomography (OCT) scans of living mouse eyes...
Mice, Inbred C57BL Tomography, Optical Coherence Anterior Eye Segment Glaucoma, Open-Angle Tonometry, Ocular Algorithms Intraocular Pressure Animals Deep Learning Mice Sclera Neural Networks, Computer
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Three-Dimensional Visualization of the Podocyte Actin Network Using Integrated Membrane Extraction, Electron Microscopy, and Machine Learning.

Journal of the American Society of Nephrology : JASN Nov 10, 2021
BACKGROUND: Actin stress fibers are abundant in cultured cells, but little is known about them . In podocytes, much evidence suggests that mechanobiologic mechanisms underlie podocyte shape and adhesion in health and in injury, with structural change...
Mice, Inbred C57BL Models, Animal Microscopy, Electron Actin Cytoskeleton Podocytes Machine Learning Animals Imaging, Three-Dimensional Mice
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Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram.

Nature methods Oct 28, 2021
Charting an organs' biological atlas requires us to spatially resolve the entire single-cell transcriptome, and to relate such cellular features to the anatomical scale. Single-cell and single-nucleus RNA-seq (sc/snRNA-seq) can profile cells comprehe...
Chromatin Software Brain Female Animals RNA-Seq Mice Mice, Inbred C57BL Gene Expression Regulation Regulatory Sequences, Nucleic Acid Male Gene Expression Profiling Transcriptome Deep Learning Single-Cell Analysis
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Cross-species behavior analysis with attention-based domain-adversarial deep neural networks.

Nature communications Sep 17, 2021
Since the variables inherent to various diseases cannot be controlled directly in humans, behavioral dysfunctions have been examined in model organisms, leading to better understanding their underlying mechanisms. However, because the spatial and tem...
Caenorhabditis elegans Dopaminergic Neurons Species Specificity Behavior, Animal Dopamine Coleoptera Humans Neural Networks, Computer Animals Mice Mice, Inbred C57BL Parkinson Disease Attention
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DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels.

eLife Sep 2, 2021
Videos of animal behavior are used to quantify researcher-defined behaviors of interest to study neural function, gene mutations, and pharmacological therapies. Behaviors of interest are often scored manually, which is time-consuming, limited to few ...
Social Behavior Pattern Recognition, Automated Drosophila melanogaster Motor Activity Grooming Reproducibility of Results Animals Male Image Processing, Computer-Assisted Mice Mice, Inbred C57BL Kinetics Walking Supervised Machine Learning Video Recording Humans Neural Networks, Computer Female
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CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice.

PLoS pathogens Aug 17, 2021
More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts millions of people in high-burden countries....
Animals, Outbred Strains Chemokine CXCL1 ROC Curve Mice Mice, Inbred C57BL Tuberculosis, Pulmonary Mycobacterium tuberculosis Biomarkers Female Animals Transcriptome Humans Machine Learning Cytokines
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Vesseg: An Open-Source Tool for Deep Learning-Based Atherosclerotic Plaque Quantification in Histopathology Images-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology Aug 12, 2021
Objective: Manual plaque segmentation in microscopy images is a time-consuming process in atherosclerosis research and potentially subject to unacceptable user-to-user variability and observer bias. We address this by releasing Vesseg a tool that inc...
Software Female Reproducibility of Results Animals Male Severity of Illness Index Diagnosis, Computer-Assisted Deep Learning Mice, Knockout, ApoE Plaque, Atherosclerotic Arteries Predictive Value of Tests Atherosclerosis Microscopy Image Interpretation, Computer-Assisted Vascular Remodeling Mice Staining and Labeling Disease Models, Animal Mice, Inbred C57BL
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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Disease Models, Animal Mice, Inbred C57BL Intestinal Mucosa Mice, Knockout AMP-Activated Protein Kinases Animals Cohort Studies Mice Treatment Outcome Colitis Organoids Multigene Family Gene Expression Regulation Molecular Targeted Therapy Likelihood Functions Dextran Sulfate Humans Artificial Intelligence Machine Learning Inflammatory Bowel Diseases Reproducibility of Results
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