AIMC Topic: Mice

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Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor κB ligand-induced NF-κB pathway.

Biochemical and biophysical research communications Dec 18, 2017
Linarin, a natural flavonoid glycoside widely found in plants, has been reported to possess anti-inflammation, neuroprotection and osteogenic properties. However, its impact on osteoclast remains unclear. In the present study, the effects of linarin ...
Glycosides NF-kappa B Osteogenesis RAW 264.7 Cells Osteoblasts Cells, Cultured Macrophages Animals RANK Ligand Mice, Inbred C57BL Dose-Response Relationship, Drug Mice Signal Transduction
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Effect of dacarbazine on CD44 in live melanoma cells as measured by atomic force microscopy-based nanoscopy.

International journal of nanomedicine Dec 18, 2017
CD44 ligand-receptor interactions are known to be involved in regulating cell migration and tumor cell metastasis. High expression levels of CD44 correlate with a poor prognosis of melanoma patients. In order to understand not only the mechanistic ba...
Quantum Dots Kinetics Dacarbazine Microscopy, Atomic Force Animals Tubulin Actins Melanoma Cell Line, Tumor Single Molecule Imaging Hyaluronan Receptors Mice Cell Survival
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Development of an artificial neural network model for risk assessment of skin sensitization using human cell line activation test, direct peptide reactivity assay, KeratinoSens™ and in silico structure alert parameter.

Journal of applied toxicology : JAT Dec 10, 2017
It is important to predict the potential of cosmetic ingredients to cause skin sensitization, and in accordance with the European Union cosmetic directive for the replacement of animal tests, several in vitro tests based on the adverse outcome pathwa...
Humans Neural Networks, Computer Lymph Nodes Cell Line Skin Skin Irritancy Tests Dermatitis, Allergic Contact Computer Simulation Animals Risk Assessment Mice
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: High-Throughput Quantification of Fluorescent Synaptic Protein Puncta by Machine Learning.

eNeuro Dec 6, 2017
Synapse formation analyses can be performed by imaging and quantifying fluorescent signals of synaptic markers. Traditionally, these analyses are done using simple or multiple thresholding and segmentation approaches or by labor-intensive manual anal...
Synapses High-Throughput Screening Assays Cells, Cultured Humans Animals Machine Learning Image Processing, Computer-Assisted Software Mice Algorithms
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Evaluation of Aristolochia indica L. and Piper nigrum L. methanol extract against centipede Scolopendra moristans L. using Wistar albino rats and screening of bioactive compounds by high pressure liquid chromatography: a polyherbal formulation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov 28, 2017
The present study was aimed to explore the anti-venom activity of Aristolochia indica and Piper nigrum plants against the centipede (Scolopendra moristans) envenomation in animal model. In vtiro phytochemical, antioxidant and blocking of proteolysis ...
Piper nigrum Proteolysis Venoms Aristolochia Electrolytes Mice Organ Specificity Lipids Humans Antioxidants Behavior, Animal Phytotherapy Phytochemicals Plant Extracts Animals Toxicity Tests, Acute Methanol Rats, Wistar Antineoplastic Agents Annelida Chromatography, High Pressure Liquid Cell Line, Tumor Antivenins
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Kaempferol modulates Angiopoietin-like protein 2 expression to lessen the mastitis in mice.

Pharmacological reports : PR Nov 22, 2017
BACKGROUND: Mastitis is inflammation of a breast (or udder). Angiopoietin-like protein 2 (ANGPTL2) has been found as a key inflammatory mediator in mastitis. Purpose of this research was to investigate the mechanisms about repressing effect of kaempf...
Angiopoietin-like Proteins Angiopoietin-Like Protein 2 Peroxidase Tumor Necrosis Factor-alpha Mastitis Mice, Inbred C57BL Interleukin-6 Inflammation Epithelial Cells Female Kaempferols Animals Mice
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Comparative analysis of weighted gene co-expression networks in human and mouse.

PloS one Nov 21, 2017
The application of complex network modeling to analyze large co-expression data sets has gained traction during the last decade. In particular, the use of the weighted gene co-expression network analysis framework has allowed an unbiased and systems-...
Animals Gene Expression Profiling Gene Regulatory Networks Mice Humans Tissue Distribution Gene Ontology Homeodomain Proteins Sequence Homology Retinoic Acid Receptor alpha Genetic Association Studies Core Binding Factor Alpha 1 Subunit Forkhead Transcription Factors Gene Expression Regulation
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Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice.

Journal of visualized experiments : JoVE Nov 18, 2017
In mice, ejaculated semen is deposited in the uterus. After ejaculation, the semen changes consistency from gel-like to watery, a process called liquefaction. In this study, we show how to collect the post-ejaculated semen from the female reproductiv...
Female Copulation Ejaculation Animals Reproduction Male Vagina Specimen Handling Mice Semen
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ClusterTAD: an unsupervised machine learning approach to detecting topologically associated domains of chromosomes from Hi-C data.

BMC bioinformatics Nov 14, 2017
BACKGROUND: With the development of chromosomal conformation capturing techniques, particularly, the Hi-C technique, the study of the spatial conformation of a genome is becoming an important topic in bioinformatics and computational biology. The Hi-...
Histone Code CCCTC-Binding Factor Binding Sites Enhancer Elements, Genetic Chromosomes Chromatin Immunoprecipitation Animals Mice Cluster Analysis Unsupervised Machine Learning Promoter Regions, Genetic Genomics Sequence Analysis, DNA
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Determination of Tedizolid susceptibility interpretive criteria for gram-positive pathogens according to clinical and laboratory standards institute guidelines.

Diagnostic microbiology and infectious disease Nov 7, 2017
For effective antibacterial therapy, physicians require qualitative test results using susceptibility breakpoints provided by clinical microbiology laboratories. This article summarizes the key components used to establish the Clinical Laboratory Sta...
Oxazolidinones Tetrazoles Linezolid Microbial Sensitivity Tests Mice Staphylococcus aureus Streptococcus agalactiae Streptococcus pyogenes Enterococcus faecalis Bacterial Load Gram-Positive Bacterial Infections Humans Anti-Bacterial Agents Animals
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